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Endothelin Receptor

Endothelin Receptor

Cat. No. Product Name CAS No. Information
CSN13675 Zibotentan 186497-07-4 Zibotentan is an orally administered potent and specific ETA-receptor endothelin A receptor antagonist IC50 21 nM
CSN29551 ZD-1611 186497-38-1 ZD1611 is an endothelin receptor antagonist.
CSN12014 Sulfisoxazole   127-69-5 Sulfisoxazole is an antagonist of endothelin receptor that can be used as a sulfonamide antibacterial agent
CSN11008 Sodium Ferulate   24276-84-4 Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease
CSN12974 Sitaxsentan Sodium 210421-74-2 Sitaxsentan sodium has selectory antagonism of endothelin A ETA receptor with the IC50 and Ki value of 14 nM and 043 nM respectively
CSN12975 Sitaxsentan 184036-34-8 Sitaxsentan is a selective endothelin A (ETA) receptor antagonist.
CSN24483 Ro 46-8443 175556-12-4 Ro 46-8443 is the first non-peptide Endothelin Receptor B selective antagonist with IC50 value of 110nM.
CSN17902 Ro 46-2005 150725-87-4 Ro 46-2005 is an antagonist of endothelin receptor
CSN25744 IRL-2500 169545-27-1 IRL-2500 is a potent endothelin receptor antagonist with IC50 values of 1.3 and 94 nM for ETB and ETA receptors respectively.
CSN23533 Darusentan   171714-84-4 Darusentan is an antagonist of endothelin ETA receptor and it can be used to treat congestive heart failure and hypertension
CSN19760 Clazosentan 180384-56-9 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
CSN17348 BQ-788 Sodium 156161-89-6 BQ-788 sodium salt is a potent selective ETB receptor antagonist with IC50 of 12 nM for inhibition of ET-1 binding to human Girardi heart cells poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM
CSN17753 BQ-123 136553-81-6 BQ-123 is a specific antagonist of endothelin A receptor ETA and the IC50 is 73 nM
CSN10481 Bosentan Hydrate   157212-55-0 Bosentan is an endothelin (ET) receptor antagonist of ET-A (Ki 4.7 nM) and ET-B (Ki 95 nM).
CSN10480 Bosentan 147536-97-8 Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
CSN18015 Atrasentan 173937-91-2 Atrasentan is an endothelin receptor antagonist (IC500.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN13753 Atrasentan HCl 195733-43-8 Atrasentan HCl is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN10496 Ambrisentan   177036-94-1 Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).
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