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Endothelin Receptor

Endothelin Receptor

Cat. No. Product Name CAS No. Information
CSN13675 Zibotentan 186497-07-4 Zibotentan is an orally administered potent and specific ETA-receptor endothelin A receptor antagonist IC50 21 nM
CSN12014 Sulfisoxazole   127-69-5 Sulfisoxazole is an antagonist of endothelin receptor that can be used as a sulfonamide antibacterial agent
CSN11008 Sodium Ferulate   24276-84-4 Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease
CSN12974 Sitaxsentan Sodium 210421-74-2 Sitaxsentan sodium has selectory antagonism of endothelin A ETA receptor with the IC50 and Ki value of 14 nM and 043 nM respectively
CSN12975 Sitaxsentan 184036-34-8 Sitaxsentan is a selective endothelin A (ETA) receptor antagonist.
CSN17902 Ro 46-2005 150725-87-4 Ro 46-2005 is an antagonist of endothelin receptor
CSN18333 Macitentan N-Butyl Analogue 556797-16-1 Macitentan n-butyl analogue is a n-butyl analogue of Macitentan ACT064992 which is an orally active non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis IPF and pulmonary arterial hypertension PAH
CSN13736 Macitentan   441798-33-0 Macitentan is an antagonist of endothelin receptor A ETA with IC50 of 05 nM It is developed for treatment of pulmonary arterial hypertension PAH
CSN22138 J-104132 198279-45-7 J-104132 is a potent, orally active ETAETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells.
CSN20320 HJP272 1072467-37-8 HJP272, an endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury.
CSN23533 Darusentan   171714-84-4 Darusentan is an antagonist of endothelin ETA receptor and it can be used to treat congestive heart failure and hypertension
CSN19760 Clazosentan 180384-56-9 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
CSN17348 BQ-788 Sodium 156161-89-6 BQ-788 sodium salt is a potent selective ETB receptor antagonist with IC50 of 12 nM for inhibition of ET-1 binding to human Girardi heart cells poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM
CSN18010 BQ-788 173326-37-9 BQ-788 is a potent and selective endothelin receptor subtype B ETB antagonist with IC50 of 12 nM inhibits 125I-labeled endothelin 1 ET-1 binding to ETB receptors on human Girardi heart cells
CSN17753 BQ-123 136553-81-6 BQ-123 is a specific antagonist of endothelin A receptor ETA and the IC50 is 73 nM
CSN10481 Bosentan Hydrate   157212-55-0 Bosentan is an endothelin (ET) receptor antagonist of ET-A (Ki 4.7 nM) and ET-B (Ki 95 nM).
CSN10480 Bosentan 147536-97-8 Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
CSN12872 Avosentan 290815-26-8 Avosentan is a potent, selective endothelin receptor (ETA receptor) antagonist.
CSN18015 Atrasentan 173937-91-2 Atrasentan is an endothelin receptor antagonist (IC500.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN13753 Atrasentan HCl 195733-43-8 Atrasentan hydrochloride is an endothelin receptor antagonist (IC500.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN10496 Ambrisentan 177036-94-1 Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).
CSN17466 ACT-132577 1103522-45-7 ACT-132577 is the major and pharmacologically active metabolite of macitentan which is dual ETAETB endothelin ET receptor antagonist designed for tissue targeting
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