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eIF
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23286 | SBI-0640756 | 2205871-61-8 | SBI-0640756 is an inhibitor of eIF4G1 which can disrupt the function of eIF4F complex |
| CSN18917 | 6-Chloro-3-[3-(5-fluoropyridin-3-yl)acryloyl]-4-phenyl-1H-quinolin-2-one | 1997370-71-4 | SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex It can also suppress AKT and NF-kB signaling |
| CSN17259 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells |
| CSN18206 | 4EGI-1 | 315706-13-9 | 4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G HNE1 cell line is the most sensitive one to 4EGI-1 and the IC50 of 4EGI-1 was about 50M at 72h |
| CSN19089 | 4E2RCat | 432499-63-3 | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 M. |
| CSN18215 | 4E1RCat | 328998-25-0 | 4E1RCat blocks interaction between eIF4E:eIF4G and eIF4E:4E-BP1, prevents assembly of the eIF4F complex and inhibits cap-dependent translation with IC50 ~4 μM. |
| CSN67681 | rel-Zotatifin | 2098191-54-7 |
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