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E1/E2/E3 Enzyme
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23792 | VL285 | 1448188-57-5 | VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins. |
| CSN20606 | VH-298 | 2097381-85-4 | VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor Kd 80-90 nM which can block the interaction of VHL and HIF- thus initiating hypoxic response |
| CSN20441 | UbcH5c Inhibitor C6d | N/A | UbcH5c inhibitor C6d exhibits potent anti-inflammatory activity against complete Freunds adjuvant-induced adjuvant arthritis in vivo and is a promising lead compound for the development of anti-rheumatoid arthritis (RA) agent. |
| CSN17382 | TZ9 | 1002789-86-7 | TZ9 is an inhibitor of Rad6 ubiquitin conjugating enzyme E2 enzyme and inhibits MDA-MB-231 cell proliferation with IC50 of 6 M |
| CSN22266 | E3 Ligand-Linker Conjugate 10 | 1957236-22-4 | Thalidomide-O-amido-PEG4-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| CSN22269 | E3 Ligand-Linker Conjugate 9 | 1957236-20-2 | Thalidomide-O-amido-PEG3-C2-Amine is a PROTAC block consist of Thalidomide and a linker with an Amine functional group for conjugation reactions. |
| CSN22270 | E3 Ligand-Linker Conjugate 8 | 1957235-74-3 | Thalidomide-O-amido-PEG2-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| CSN22271 | E3 Ligand-Linker Conjugate 7 | 2022182-59-6 | Thalidomide-O-amido-PEG-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| CSN22274 | E3 Ligand-Linker Conjugate 3 | 1799711-24-2 | Thalidomide-O-amido-C4-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| CSN22272 | E3 Ligand-Linker Conjugate 6 | 2022182-57-4 | Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| CSN24768 | Thalidomide-linker 2 | 2245697-85-0 | Thalidomide-linker 2 is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| CSN22519 | Teslexivir | 1075798-37-6 | Teslexivir is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins E1 and E2 an interaction that is a necessary step for Human Papilloma Virus HPV 6 and 11 DNA replication and thus viral production |
| CSN21424 | E3 ligase Ligand 3 | 1061605-21-7 | TC E3 5031 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component. |
| CSN24144 | TAK-981 | 1858276-04-6 | TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities. |
| CSN21083 | TAK-243 | 1450833-55-2 | TAK-243, also known as MLN7243 and AOB87172, is a small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. |
| CSN17260 | SZL P1-41 | 222716-34-9 | SZL P1-41 is Skp2 inhibitor selectively suppresses Skp2 E3 ligase activity but not activity of other SCF complexes |
| CSN24085 | Smurf1-IN-A01 | 1007647-73-5 | Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation. |
| CSN25714 | SMER 3 | 67200-34-4 | SMER 3 is a selective inhibitor of yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. |
| CSN18272 | Skp2 Inhibitor C1 | 432001-69-9 | Skp2 inhibitor C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. |
| CSN16569 | PYZD-4409 | 423148-78-1 | PYZD-4409 is a small molecule inhibitor of Ubiquitin-activating enzyme UBA1E1 enzyme with an IC50 of 20 M cell-free enzymatic assay |
| CSN15975 | PYR-41 | 418805-02-4 | PYR-41 (50 μM) inhibits activity of ubiquitin-activating enzyme E1 by over 90%. |
| CSN18199 | PRT4165 | 31083-55-3 | PRT4165 an inhibitor of bim1 and ring1A could block PRC1 Polycomb-repressive complex 1-mediated H2A ubiquitylation |
| CSN22492 | PROTAC Linker 1 | 1835705-53-7 | PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand. |
| CSN23937 | PROTAC BRD9 Degrader-1 | 2097971-01-0 | PROTAC BRD9 Degrader-1 is a PROTAC targeting on BRD9, consist of a BRD9 bromodomain probe I-BRD9 as a warhead ligand and pomalidomide as the CRBN ligand. |
| CSN19741 | PK11195 | 85532-75-8 | PK11195 is a 2Phenylindolylglyoxylyldipeptide Murine Double Minute2 MDM2Translocator Protein TSPOHuman Constitutive Androstane Receptor hCAR Inhibitor and is potentially useful for the Treatment of Gliomas |
| CSN17303 | NSC 697923 | 343351-67-7 | NSC 697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme E2 complex Ubc13-Uev1A |
| CSN25713 | N106 | 862974-25-2 | N106 is an activator of SUMO-activating enzyme E1 ligase. It can increase SERCA2a SUMOylation and activity and enhance contractility in rat cardiomyocytes in vitro. |
| CSN20617 | ML-792 | 1644342-14-2 | ML-792 is a mechanism-based SUMO-activating enzyme SAE inhibitor with nanomolar potency in cellular assays which selectively blocks SAE enzyme activity and total SUMOylation thus decreasing cancer cell proliferation |
| CSN20357 | MDK7526 | 1448297-52-6 | MDK7526 is a ligand of Von HippelLindau protein, that can be used for making proteolysis targeting chimeras (PROTACs). |
| CSN27287 | LS-102 | 1456891-34-1 | LS-102 is a selective inhibitor of E3 ubiquitin ligase synoviolin (Syvn1). LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment. |
| CSN22273 | E3 Ligand-Linker Conjugate 4 | 2093388-45-3 | Lenalidomide-C5-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| CSN22267 | E3 Ligand-Linker Conjugate 5 | 2093388-69-1 | Lenalidomide-C4-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| CSN22090 | IACS-9571 | 1800477-30-8 | IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively. |
| CSN22427 | HaloPROTAC 1 | 1799506-06-1 | HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions. |
| CSN21237 | E3 Ligase Ligand 6 | 1631137-51-3 | E3 Ligase Ligand 6 is used for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component. |
| CSN21420 | E3 ligase Ligand 2 | 5054-59-1 | E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component. |
| CSN21252 | E3 Ligase Ligand 1A | 1948273-02-6 | E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component. |
| CSN23876 | COH000 | 1534358-79-6 | COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro. |
| CSN17689 | CC0651 | 1319207-44-7 | CC0651 is an allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme that potently IC50 172 M inhibited the ubiquitination of p27 Kip1 |
| CSN27230 | (S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile | 2259648-80-9 | CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity . |
| CSN22248 | CC-885 | 1010100-07-8 | CC-885 is a cereblon CRBN modulator with potent anti-tumour activity |
| CSN19693 | CC-220 | 1323403-33-3 | CC-220 is a modulator of cereblon that is potential to treat systemic lupus erythematosis and multiple myeloma |
| CSN15860 | CC-122 | 1015474-32-4 | CC-122 also known as avadomide binds to CRBN and induces degradation of aiolos and ikaros that result in cell apoptosis It is a antitumor and immunomodulatory agent used to treat DLBCL |
| CSN24473 | C25-140 | 1358099-18-9 | C25-140 is an inhibitor of the TRAF6-Ubc13 interaction that reduces TRAF6-Ubc13 activity both in vitro and in cells. |
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