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DUB
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13933 | VLX1570 | 1431280-51-1 | VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10M in vitro and shows coinhibition of the deubiquitinating enzymes like USP14 and UCHL5 |
| CSN17621 | USP7/USP47 inhibitor | 1247825-37-1 | USP7-USP47 inhibitor is a potent and dual inhibitor of USP7USP47 with IC50s of 042 M USP7 and 10 M USP47 |
| CSN17772 | USP7-IN-1 | 1381291-36-6 | USP7-IN-1 is a selective and reversible inhibitor of USP7 with IC50 of 33 M showing less or no inhibition on USP5 USP8 Uch-L1 Uch-L3 and Caspase IC50 200 M For HCT116 cell the viability GI50 is 67 M |
| CSN25613 | USP25/28 inhibitor AZ1 | 2165322-94-9 | USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively. |
| CSN19439 | TCID | 30675-13-9 | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 06 M 125-fold selective to L1 |
| CSN18929 | SJB3-019A | 2070015-29-9 | SJB3-019A is a potent USP1 inhibitor 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 00781 M |
| CSN16328 | SJB2-043 | 63388-44-3 | SJB2-043 is an inhibitor of ubiquitin-specific protease 1 USP1 and it is one of derivatives of C527 |
| CSN26164 | RA-9 | 919091-63-7 | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。 |
| CSN13807 | PR-619 | 2645-32-1 | PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes DUBs with EC50 of 1-20 M and it was developed for chemotherapy |
| CSN13634 | P 22077 | 1247819-59-5 | P22077 is an inhibitor of ubiquitin specific protease USP7 EC50 86 M P22077 also inhibits the deubiquitinase USP47 |
| CSN16620 | P005091 | 882257-11-6 | P005091 acts as a selective inhibitor of ubiquitin-specific protease 7 USP7 and USP47 with the EC50s of 42 M and 43 M respectively |
| CSN18918 | NSC632839 | 157654-67-6 | NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively). |
| CSN18920 | ML364 | 1991986-30-1 | ML364 is an USP2 inhibitor |
| CSN15929 | ML-323 | 1572414-83-5 | ML323 exhibits reversible inhibition of USP1-UAF1 with IC50 of 76 nM and it also inhibits deneddylase and deSUMOylase |
| CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 088 M Ki 04 M and its selectivity is better than UCH-L3 IC50 25 M |
| CSN22847 | HBX 41108 | 924296-39-9 | HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity with IC50 of 424 nM. |
| CSN17834 | HBX 19818 | 1426944-49-1 | HBX 19818 is a selective USP7 inhibitor with IC50 of 281 M |
| CSN23352 | GNE-6776 | 2009273-71-4 | GNE-6776 is selective ubiquitin specific protease-7 USP7 inhibitor with IC50 of 134 M through binding to acidic amino acid residues |
| CSN23348 | GNE-6640 | 2009273-67-8 | GNE-6640 is a selective inhibitor of ubiquitin specific protease-7 USP7 IC50 075 M that can induce tumor cell death and enhance the effect of chemotherapy drugs |
| CSN22406 | FT827 | 1959537-86-0 | FT827 is a selective and covalent ubiquitin-specific protease 7 USP7 inhibitor with an IC50 of 52 nM |
| CSN21254 | FT671 | 1959551-26-8 | FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM |
| CSN25574 | EOAI3402143 | 1699750-95-2 | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which dose-dependently inhibits Usp9x/Usp24 and Usp5. |
| CSN18587 | DUB-IN-3 | 924296-17-3 | DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 31 M for USP8 showing 30 fold selectivity over USP7 IC50 100 M |
| CSN18589 | DUB-IN-2 | 924296-19-5 | DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 72 M093 M for USP7USP8 respectively |
| CSN18588 | DUB-IN-1 | 924296-18-4 | DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 M071 M for USP7USP8 respectively |
| CSN21377 | C527 | 192718-06-2 | C527 is a is a pan DUB enzyme inhibitor with a high potency for the USP1UAF1 complex IC50088 M |
| CSN15845 | b-AP15 | 1009817-63-3 | b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 and ubiquitin-specific-processing protease 14 USP14 In purified 19S proteasomes b-AP15 can inhibit DUB activity with an IC50 of 21 M |
| CSN10355 | Auranofin | 34031-32-8 | Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-B activation, Auranofin can attenuats the cardiac hypertrophy. |
| CSN39367 | GSK2643943A | 2449301-27-1 | |
| CSN39434 | (R)-FT671 | 1959551-27-9 | |
| CSN38063 | LDN-91946 | 439946-22-2 | |
| CSN39074 | 6RK73 | 1895050-66-4 | |
| CSN51364 | IU1-248 | 2307472-03-1 | |
| CSN75088 | (R)-3-(4-(Aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | 2196243-57-7 | |
| CSN75189 | KSQ-4279 | 2446480-97-1 |
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