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DUB
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16328 | SJB2-043 | 63388-44-3 | SJB2-043 is an inhibitor of ubiquitin-specific protease 1 USP1 and it is one of derivatives of C527 |
| CSN13807 | PR-619 | 2645-32-1 | PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes DUBs with EC50 of 1-20 M and it was developed for chemotherapy |
| CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 088 M Ki 04 M and its selectivity is better than UCH-L3 IC50 25 M |
| CSN21377 | C527 | 192718-06-2 | C527 is a is a pan DUB enzyme inhibitor with a high potency for the USP1UAF1 complex IC50088 M |
| CSN10355 | Auranofin | 34031-32-8 | Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-B activation, Auranofin can attenuats the cardiac hypertrophy. |
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