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DUB

DUB

Cat. No. Product Name CAS No. Information
CSN13933 VLX1570 1431280-51-1 VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10M in vitro and shows coinhibition of the deubiquitinating enzymes like USP14 and UCHL5
CSN17621 USP7-USP47 Inhibitor 1247825-37-1 USP7-USP47 inhibitor is a potent and dual inhibitor of USP7USP47 with IC50s of 042 M USP7 and 10 M USP47
CSN17772 USP7-IN-1 1381291-36-6 USP7-IN-1 is a selective and reversible inhibitor of USP7 with IC50 of 33 M showing less or no inhibition on USP5 USP8 Uch-L1 Uch-L3 and Caspase IC50 200 M For HCT116 cell the viability GI50 is 67 M
CSN19439 TCID 30675-13-9 TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 06 M 125-fold selective to L1
CSN18929 SJB3-019A 2070015-29-9 SJB3-019A is a potent USP1 inhibitor 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 00781 M
CSN16328 SJB2-043 63388-44-3 SJB2-043 is an inhibitor of ubiquitin-specific protease 1 USP1 and it is one of derivatives of C527
CSN13807 PR-619   2645-32-1 PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes DUBs with EC50 of 1-20 M and it was developed for chemotherapy
CSN13634 P22077 1247819-59-5 P22077 is an inhibitor of ubiquitin specific protease USP7 EC50 86 M P22077 also inhibits the deubiquitinase USP47
CSN16620 P005091   882257-11-6 P005091 acts as a selective inhibitor of ubiquitin-specific protease 7 USP7 and USP47 with the EC50s of 42 M and 43 M respectively
CSN18918 NSC 632839 HCl 157654-67-6 NSC 632839 hydrochloride is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2 USP7 and SENP2 EC50 45 4 M 37 1 M and 98 18 M respectively
CSN18920 ML364 1991986-30-1 ML364 is an USP2 inhibitor
CSN15929 ML323 1572414-83-5 ML323 exhibits reversible inhibition of USP1-UAF1 with IC50 of 76 nM and it also inhibits deneddylase and deSUMOylase
CSN18381 LDN-57444   668467-91-2 LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 088 M Ki 04 M and its selectivity is better than UCH-L3 IC50 25 M
CSN17834 HBX 19818 1426944-49-1 HBX 19818 is a selective USP7 inhibitor with IC50 of 281 M
CSN23352 GNE-6776 2009273-71-4 GNE-6776 is selective ubiquitin specific protease-7 USP7 inhibitor with IC50 of 134 M through binding to acidic amino acid residues
CSN23348 GNE-6640 2009273-67-8 GNE-6640 is a selective inhibitor of ubiquitin specific protease-7 USP7 IC50 075 M that can induce tumor cell death and enhance the effect of chemotherapy drugs
CSN22406 FT827 1959537-86-0 FT827 is a selective and covalent ubiquitin-specific protease 7 USP7 inhibitor with an IC50 of 52 nM
CSN21254 FT671 1959551-26-8 FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM
CSN18587 DUBs-IN-3 924296-17-3 DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 31 M for USP8 showing 30 fold selectivity over USP7 IC50 100 M
CSN18589 DUBs-IN-2 924296-19-5 DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 72 M093 M for USP7USP8 respectively
CSN18588 DUBs-IN-1 924296-18-4 DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 M071 M for USP7USP8 respectively
CSN21377 C527 192718-06-2 C527 is a is a pan DUB enzyme inhibitor with a high potency for the USP1UAF1 complex IC50088 M
CSN15845 b-AP15 1009817-63-3 b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 and ubiquitin-specific-processing protease 14 USP14 In purified 19S proteasomes b-AP15 can inhibit DUB activity with an IC50 of 21 M
CSN10355 Auranofin 34031-32-8 Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-B activation, Auranofin can attenuats the cardiac hypertrophy.
CSN22847 HBX 41108 924296-39-9
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