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DUB

DUB

Cat. No. Product Name CAS No. Information
CSN13933 VLX1570 1431280-51-1 VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10M in vitro and shows coinhibition of the deubiquitinating enzymes like USP14 and UCHL5
CSN25613 USP25/28 inhibitor AZ1 2165322-94-9 USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively.
CSN19439 TCID 30675-13-9 TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 06 M 125-fold selective to L1
CSN16328 SJB2-043 63388-44-3 SJB2-043 is an inhibitor of ubiquitin-specific protease 1 USP1 and it is one of derivatives of C527
CSN26164 RA-9   919091-63-7 RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。
CSN13807 PR-619   2645-32-1 PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes DUBs with EC50 of 1-20 M and it was developed for chemotherapy
CSN18918 NSC 632839 HCl 157654-67-6 NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively).
CSN18381 LDN-57444   668467-91-2 LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 088 M Ki 04 M and its selectivity is better than UCH-L3 IC50 25 M
CSN21254 FT671 1959551-26-8 FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM
CSN21377 C527 192718-06-2 C527 is a is a pan DUB enzyme inhibitor with a high potency for the USP1UAF1 complex IC50088 M
CSN15845 b-AP15 1009817-63-3 b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 and ubiquitin-specific-processing protease 14 USP14 In purified 19S proteasomes b-AP15 can inhibit DUB activity with an IC50 of 21 M
CSN10355 Auranofin 34031-32-8 Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-B activation, Auranofin can attenuats the cardiac hypertrophy.
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