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DUB
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13933 | VLX1570 | 1431280-51-1 | VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10M in vitro and shows coinhibition of the deubiquitinating enzymes like USP14 and UCHL5 |
| CSN25613 | USP25/28 inhibitor AZ1 | 2165322-94-9 | USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively. |
| CSN19439 | TCID | 30675-13-9 | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 06 M 125-fold selective to L1 |
| CSN16328 | SJB2-043 | 63388-44-3 | SJB2-043 is an inhibitor of ubiquitin-specific protease 1 USP1 and it is one of derivatives of C527 |
| CSN26164 | RA-9 | 919091-63-7 | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。 |
| CSN13807 | PR-619 | 2645-32-1 | PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes DUBs with EC50 of 1-20 M and it was developed for chemotherapy |
| CSN18918 | NSC 632839 HCl | 157654-67-6 | NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively). |
| CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 088 M Ki 04 M and its selectivity is better than UCH-L3 IC50 25 M |
| CSN21254 | FT671 | 1959551-26-8 | FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM |
| CSN21377 | C527 | 192718-06-2 | C527 is a is a pan DUB enzyme inhibitor with a high potency for the USP1UAF1 complex IC50088 M |
| CSN15845 | b-AP15 | 1009817-63-3 | b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 and ubiquitin-specific-processing protease 14 USP14 In purified 19S proteasomes b-AP15 can inhibit DUB activity with an IC50 of 21 M |
| CSN10355 | Auranofin | 34031-32-8 | Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-B activation, Auranofin can attenuats the cardiac hypertrophy. |
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