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DNA/RNA Synthesis

DNA/RNA Synthesis

Cat. No. Product Name CAS No. Information
CSN16911 YK-4-279   1037184-44-3 YK 4-279 is a potent inhibitor of RNA Helicase A RHA that binding to the oncogenic transciption factor EWS-FLI1
CSN16802 Vidarabine   5536-17-4 Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses.
CSN13562 Triapine   143621-35-6 Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.
CSN12039 Tegafur   17902-23-7 Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers.
CSN15712 Sofosbuvir   1190307-88-0 Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection.
CSN11844 Rifapentine   61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN16146 Rifampicin   13292-46-1 Rifampin is a bacterial RNA polymerase inhibitor used in the treatment of bacterial infections
CSN19260 Pyridostatin Trifluoroacetate 1472611-44-1 Pyridostatin Trifluoroacetate stabilizes and binds G-quadruplexe with Kd of 490 nM cell-free assay which targets the proto-oncogene c-kit K-ras and Bcl-2
CSN19697 Nitrobenzylthioinosine 38048-32-7 Nitrobenzylthioinosine is an inhibitor of Equilibrative Nucleoside Transporter 1 (ENT1).
CSN16103 Nelarabine 121032-29-9 Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 M in tumor cells.
CSN19748 MS444 150045-18-4 MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs
CSN11454 Mizoribine     50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN19728 LSS-11 1392014-36-6 LSS-11 bound to DNA in vitro and in cell mainly by minor groove binding and significantly increased the stability of DNA which could be fundamental for the biological activities of LSS-11 It can inhibit multiple DNA-associated processes and tumor growth
CSN16113 Hydroxyurea   127-07-1 Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CSN11136 Halofuginone 55837-20-2 Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF- signaling at 10 ngmL in mammal.
CSN11086 Gemcitabine   95058-81-4 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN16647 Gemcitabine HCl   122111-03-9 Gemcitabine hydrochloride is a DNA synthesis inhibitor with IC50 of 50 nM 40 nM 18 nM and 12 nM in PANC1 MIAPaCa2 BxPC3 and Capan2 cells respectively
CSN10050 Folic Acid   59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN10528 Fludarabine     21679-14-1 Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
CSN16461 Fludarabine Phosphate   75607-67-9 Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
CSN18715 Floxuridine   50-91-9 Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 M for the inhibition of PEPT1.
CSN17043 Fidaxomicin   873857-62-6 Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
CSN16684 Daptomycin 103060-53-3 Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms including multi-resistant strains
CSN10080 Dacarbazine   4342-03-4 Dacarbazine is an antineoplastic agent with significant activity against melanomas, by acting as an alkylating agent and inhibiting DNA synthesis as a purine analog
CSN19369 Cytarabine   147-94-4 Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.
CSN18773 CRT0044876   6960-45-8 CRT0044876 is a potent and selective APE1 inhibitor with IC50 of 3 M.
CSN10693 Cordycepin   73-03-0 Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent Cordycepin inhibits growth of various tumor cells in vitro It can be converted to 3-deoxyadenosine triphosphate 3-dATP which inhibits ATP-dependent DNA synthesis Cordycepin is also useful for the study of messenger RNA transcription
CSN16701 Clofarabine   123318-82-1 Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
CSN10636 Cidofovir 113852-37-2 Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
CSN12631 Chlorambucil   305-03-3 Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia.
CSN10592 Cefuroxime 55268-75-2 Cefuroxime is a second-generation variety of cephalosporins with less susceptibility to beta-lactamase
CSN10587 Ceftiofur HCl   103980-44-5 Ceftiofur HCl is a cephalosporin antibiotic used to treat both Gram-positive and Gram-negative bacteria infection
CSN10584 Cefquinome Sulfate   118443-89-3 Cefquinome Sulfate is an antibacterial used in the treatment of infections caused by pathogens such as S aureus E coli Streptococcus P multocida and A pleuropneumoniae
CSN20655 CBL0137 1197996-80-7 CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-B and promoting cancer cell death.
CSN16176 Capecitabine   154361-50-9 Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU and used as an anti-cancer prodrug
CSN12816 Bromodeoxyuridine   59-14-3 Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA.
CSN16976 BMH-21   896705-16-1 BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I Pol I transcription and does not cause phosphorylation of H2AX
CSN10472 Bleomycin Sulfate 9041-93-4 Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle.
CSN10391 Bendamustine HCl 3543-75-7 Bendamustine HCl is a DNA-damaging agent with IC50 of 50 M.
CSN16813 Beaucage Reagent   66304-01-6 Beaucage Reagent is potent in causing DNA cleavage.
CSN18126 BCX 4430 HCl 222631-44-9 BCX 4430 hydrochloride is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN16282 BCX 4430 Free Base 249503-25-1 BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN18231 BAY 57-1293 348086-71-5 BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
CSN19282 APE1 Inhibitor C10 1227098-30-7 APE1 inhibitor C10 is a small molecular inhibitor which has a potent in treating Kaposis sarcoma-associated herpesvirus KSHV
CSN18759 Ancitabine HCl   10212-25-6 Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
CSN10257 α-Amanitin 23109-05-9 alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II
CSN10160 6-Thio-dG 789-61-7 6-Thio-dG is a nucleoside analog and telomerase substrate.
CSN16373 6-Mercaptopurine   50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis its an immunosuppressive and antileukemic drug
CSN12836 6-Mercaptopurine Monohydrate   6112-76-1 6-Mercaptopurine inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug.
CSN19496 5-Fluorouracil   51-21-8 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
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