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DNA/RNA Synthesis

DNA/RNA Synthesis

Cat. No. Product Name CAS No. Information
CSN10257 α-Amanitin 23109-05-9 α-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
CSN16802 Vidarabine   5536-17-4 Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses.
CSN21982 Tetrahydrouridine 18771-50-1 Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA).
CSN15712 Sofosbuvir   1190307-88-0 Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection.
CSN19950 Saikosaponin C 20736-08-7 Saikosaponin C, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant, anti-inflammatory and cytotoxic activities, has an inhibitory activity against allergic asthma. It also shows an inhibitory for cell growth and DNA synthesis with 50-gmL.
CSN25509 2'-Deoxy-2'-fluorouridine 784-71-4 RNA that was modified with 2'-deoxy-2'-fluorouridine yielded full length HIV-1 reverse transcription products, with complete fidelity in transcription. RNA analogue, FF, containing two molecules of 2'-deoxy-2'-alpha-fluorouridine in place of uridine efficiently inhibited the RNase L-catalyzed RNA cleavage reaction.
CSN11844 Rifapentine   61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN19455 Panaxadiol 19666-76-3 Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C.
CSN21764 Nitracrine 4533-39-5 Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. 
CSN25485 N,N-Dimethylguanosine 2140-67-2 N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA.
CSN16113 Hydroxyurea   127-07-1 Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CSN25484 L-Guanosine 26578-09-6 Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. L-Guanosine is the L configuration of Guanosine.
CSN10050 Folic Acid   59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN17043 Fidaxomicin   873857-62-6 Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
CSN14493 Euscaphic Acid 53155-25-2 Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
CSN24306 Cytidine 65-46-3 Cytidine is a non-essential aminoacid.
CSN19369 Cytarabine   147-94-4 Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.
CSN10636 Cidofovir 113852-37-2 Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
CSN20655 CBL0137 1197996-80-7 CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-B and promoting cancer cell death.
CSN12816 Bromodeoxyuridine   59-14-3 Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA.
CSN10073 Blasticidin S HCl 3513-03-9 Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA.
CSN18126 BCX 4430 HCl 222631-44-9 BCX 4430 HCl is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN16282 BCX 4430 Free Base 249503-25-1 BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN18231 BAY 57-1293 348086-71-5 BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
CSN18759 Ancitabine HCl   10212-25-6 Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
CSN18264 A2AR-Agonist-1 41552-95-8 A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.
CSN23866 8-Chloroadenosine 34408-14-5 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis.
CSN25488 2-Amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one 4016-63-1 8-Bromoguanosine is a brominated derivative of guanosine.
CSN25518 6-Thioguanosine 85-31-4 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids.
CSN10160 6-Thio-dG 789-61-7 6-Thio-dG is a nucleoside analog and telomerase substrate.
CSN12836 6-Mercaptopurine Monohydrate   6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN16373 6-Mercaptopurine   50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN25506 5-Iododeoxycytidine 611-53-0 5-Iododeoxycytidine is used in the construction of DNA oligomers.
CSN25526 5-Iodo-cytidine 1147-23-5 5-Iodocytidine is used for research in the field of nucleic acids and nucleic acid-protein interactions.
CSN25507 5-Fluorouridine 316-46-1 5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity and cytotoxic activity. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM. 5-Fluorouridine triphosphate acted as a potent competitive inhibitor of VPg uridylylation, the initial step of viral replication.
CSN25530 5-Fluorocytidine 2341-22-2 5-Fluorocytidine could replace cytidine and be incorporated into cellular RNAs or tRNAs.The bacterial enzyme cytosine deaminase has been used as a negative selection marker system. Cells that express cytosine deaminase convert 5-fluorocytosine to the toxic compound 5-fluorouracil, and transformed seedlings can thus be identified using medium containing 5-fluorocytosine.
CSN25480 5-Ethynyluridine 69075-42-9 5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA. Once fed to cells, it is incorporated during active RNA synthesis and can then be detected using a copper-catalyzed click reaction with fluorescent dyes. The cells can then be analysed by fluorescence imaging, flow cytometry or high content imaging analysis.
CSN25508 5-Bromouridine 957-75-5 5-Bromouridine is used to label RNA in measurement of RNA production.
CSN25531 5-Bromocytidine 3066-86-2 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent.
CSN25483 3'-O-Acetylthymidine 21090-30-2 3'-O-Acetylthymidine is a useful modified nucleoside.
CSN25481 3'-O-(TBDMS)Thymidine 40733-27-5 3'-O-(TBDMS)Thymidine is a useful modified nucleoside.
CSN25486 2-O-Methylguanosine 2140-71-8 2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine as a substrate.
CSN25490 2'-O-(2-Methoxyethyl)-guanosine 473278-54-5 2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative as building blocks for cross-linking oligonucleotides.
CSN18758 2'-Deoxycytidine HCl 3992-42-5 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
CSN25516 2'-Deoxyadenosine 958-09-8 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
CSN25491 (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate 3181-38-2 2',3',5'-Tri-O-acetylinosine is an intermediate used for the synthesis of 6-substituted purine ribosides.
CSN25487 2-Amino-9-((2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one 22837-44-1
CSN25489 N-Isobutyrylguanosine 64350-24-9
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