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DNA/RNA Synthesis
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN24863 | Uridine 5'-monophosphate | 58-97-9 | Uridine 5'-monophosphate is a nucleotide that is used as a monomer in RNA. |
| CSN43681 | TK216 | 1903783-48-1 | TK-216, an analog of YK-4-279 inhibitor, is a potent and selective EWS-FLI1 inhibitor. TK-216 is in early clinical development for the treatment of Ewing sarcoma. |
| CSN21982 | Tetrahydrouridine | 18771-50-1 | Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA). |
| CSN51391 | SC13 | 2098776-03-3 | SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model. |
| CSN25509 | 2'-Deoxy-2'-fluorouridine | 784-71-4 | RNA that was modified with 2'-deoxy-2'-fluorouridine yielded full length HIV-1 reverse transcription products, with complete fidelity in transcription. RNA analogue, FF, containing two molecules of 2'-deoxy-2'-alpha-fluorouridine in place of uridine efficiently inhibited the RNase L-catalyzed RNA cleavage reaction. |
| CSN32990 | RRM1 Inhibitor 1 | 2563874-93-9 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors;TNF-alpha (ARE sequence)/ELAV-Like protein 1 (HuR) Interaction Inhibitors |
| CSN32991 | RRM1 Inhibitor 2 | 2247176-87-8 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
| CSN32994 | RRM1 Inhibitor 5 | 1271734-91-8 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
| CSN32992 | RRM1 Inhibitor 3 | 1819992-33-0 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
| CSN26441 | RG7800 | 1449598-06-4 | RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy. |
| CSN21764 | Nitracrine | 4533-39-5 | Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. |
| CSN25485 | N,N-Dimethylguanosine | 2140-67-2 | N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA. |
| CSN19748 | MS444 | 150045-18-4 | MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs |
| CSN43591 | Metarrestin | 1443414-10-5 | Metarrestin is a specific inhibitor of perinuclear compartment (PNC). |
| CSN33100 | Indisulam analog 4 | 444579-59-3 | Indisulam analog 4, as molecular glue, is especially effective and improves the half maximal effective concentration (EC50) to 1.21 µM in recruiting RBM39 to the DCAF15–DDB1–DDA1 complex. |
| CSN26246 | HAMNO | 138736-73-9 | HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. It has shown to significantly inhibits colony formation when combined with etoposide. |
| CSN23239 | Guanosine | 118-00-3 | Guanosine is a purine nucleoside. |
| CSN29504 | Gemcitabine monophosphate | 116371-67-6 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| CSN22052 | 2'-Deoxypseudouridine | 39967-60-7 | Deoxypseudouridine is a nucleotide analog. |
| CSN24877 | Cytidine 5′-triphosphate (disodium salt) | 36051-68-0 | Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. |
| CSN25243 | CMLD-2 | 958843-91-9 | CMLD-2 competitively binds to Hu antigen R with Ki value of 350nM and disrupts the interaction of HuR and ARE (adenine- and uridine-rich element) of target mRNAs. |
| CSN27392 | AV-153 free base | 19350-66-4 | AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity. |
| CSN32946 | COH-4 | 1190932-36-5 | Apoptosis Inducers; RRM2 Expression Inhibitors |
| CSN32948 | COH-20 | 1190932-37-6 | Apoptosis Inducers; RRM2 Expression Inhibitors |
| CSN32947 | COH-2 | 20217-22-5 | Apoptosis Inducers; RRM2 Expression Inhibitors |
| CSN18264 | A2AR-Agonist-1 | 41552-95-8 | A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1. |
| CSN23866 | 8-Chloroadenosine | 34408-14-5 | 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis. |
| CSN25488 | 8-Bromoguanosine | 4016-63-1 | 8-Bromoguanosine is a brominated derivative of guanosine. |
| CSN25518 | 6-Thioguanosine | 85-31-4 | 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids. |
| CSN12836 | 6-Mercaptopurine Monohydrate | 6112-76-1 | 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
| CSN16373 | 6-Mercaptopurine | 50-44-2 | 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
| CSN24938 | 5-Methylcytosine | 554-01-8 | 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. |
| CSN24883 | 5-Methyl-2'-deoxycytidine | 838-07-3 | 5-Methyl-2'-deoxycytidine (5-Me-dC) is a minor component found in most eukaryotic DNA. |
| CSN25506 | 5-Iododeoxycytidine | 611-53-0 | 5-Iododeoxycytidine is used in the construction of DNA oligomers. |
| CSN25526 | 5-Iodo-cytidine | 1147-23-5 | 5-Iodocytidine is used for research in the field of nucleic acids and nucleic acid-protein interactions. |
| CSN25507 | 5-Fluorouridine | 316-46-1 | 5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity and cytotoxic activity. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM. 5-Fluorouridine triphosphate acted as a potent competitive inhibitor of VPg uridylylation, the initial step of viral replication. |
| CSN25530 | 5-Fluorocytidine | 2341-22-2 | 5-Fluorocytidine could replace cytidine and be incorporated into cellular RNAs or tRNAs.The bacterial enzyme cytosine deaminase has been used as a negative selection marker system. Cells that express cytosine deaminase convert 5-fluorocytosine to the toxic compound 5-fluorouracil, and transformed seedlings can thus be identified using medium containing 5-fluorocytosine. |
| CSN25508 | 5-Bromouridine | 957-75-5 | 5-Bromouridine is used to label RNA in measurement of RNA production. |
| CSN25531 | 5-Bromocytidine | 3066-86-2 | 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent. |
| CSN27391 | 3,4-Dihydroxybenzylamine hydrobromide | 16290-26-9 | 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity. |
| CSN25490 | 2'-O-(2-Methoxyethyl)-guanosine | 473278-54-5 | 2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative as building blocks for cross-linking oligonucleotides. |
| CSN18758 | 2'-Deoxycytidine HCl | 3992-42-5 | 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. |
| CSN25516 | 2'-Deoxyadenosine | 958-09-8 | 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA. |
| CSN25491 | 2′,3′,5′-Tri-O-acetylinosine | 3181-38-2 | 2',3',5'-Tri-O-acetylinosine is an intermediate used for the synthesis of 6-substituted purine ribosides. |
| CSN25487 | 2-Amino-9-((2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one | 22837-44-1 | |
| CSN25489 | N-Isobutyrylguanosine | 64350-24-9 | |
| CSN27830 | NSAH | 1099592-35-4 |
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