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DNA/RNA Synthesis
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN10257 | α-Amanitin | 23109-05-9 | α-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II. |
| CSN16911 | YK-4-279 | 1037184-44-3 | YK 4-279 is a potent inhibitor of RNA Helicase A RHA that binding to the oncogenic transciption factor EWS-FLI1 |
| CSN16802 | Vidarabine | 5536-17-4 | Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses. |
| CSN13562 | Triapine | 143621-35-6 | Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor. |
| CSN20038 | Thailanstatin A | 1426953-21-0 | Thailanstatin A is a spliceosome inhibitor that disrupts cancer by inhibiting DNA-editing machinery |
| CSN21982 | Tetrahydrouridine | 18771-50-1 | Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA). |
| CSN12039 | Tegafur | 17902-23-7 | Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers. |
| CSN15712 | Sofosbuvir | 1190307-88-0 | Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection. |
| CSN19950 | Saikosaponin C | 20736-08-7 | Saikosaponin C, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant, anti-inflammatory and cytotoxic activities, has an inhibitory activity against allergic asthma. It also shows an inhibitory for cell growth and DNA synthesis with 50-gmL. |
| CSN11844 | Rifapentine | 61379-65-5 | Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis. |
| CSN19697 | Nitrobenzylthioinosine | 38048-32-7 | Nitrobenzylthioinosine is an inhibitor of Equilibrative Nucleoside Transporter 1 (ENT1). |
| CSN21764 | Nitracrine | 4533-39-5 | Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. |
| CSN16103 | Nelarabine | 121032-29-9 | Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 M in tumor cells. |
| CSN11454 | Mizoribine | 50924-49-7 | Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. |
| CSN16113 | Hydroxyurea | 127-07-1 | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. |
| CSN11136 | Halofuginone | 55837-20-2 | Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF- signaling at 10 ngmL in mammal. |
| CSN11086 | Gemcitabine | 95058-81-4 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| CSN10050 | Folic Acid | 59-30-3 | Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
| CSN10528 | Fludarabine | 21679-14-1 | Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies. |
| CSN16461 | Fludarabine Phosphate | 75607-67-9 | Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
| CSN18715 | Floxuridine | 50-91-9 | Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 M for the inhibition of PEPT1. |
| CSN17043 | Fidaxomicin | 873857-62-6 | Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. |
| CSN16684 | Daptomycin | 103060-53-3 | Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms including multi-resistant strains |
| CSN10080 | Dacarbazine | 4342-03-4 | Dacarbazine is an antineoplastic agent with significant activity against melanomas, by acting as an alkylating agent and inhibiting DNA synthesis as a purine analog |
| CSN24306 | Cytidine | 65-46-3 | Cytidine is a non-essential aminoacid. |
| CSN19369 | Cytarabine | 147-94-4 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. |
| CSN18773 | CRT0044876 | 6960-45-8 | CRT0044876 is a potent and selective APE1 inhibitor with IC50 of 3 M. |
| CSN10693 | Cordycepin | 73-03-0 | Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent Cordycepin inhibits growth of various tumor cells in vitro It can be converted to 3-deoxyadenosine triphosphate 3-dATP which inhibits ATP-dependent DNA synthesis Cordycepin is also useful for the study of messenger RNA transcription |
| CSN16701 | Clofarabine | 123318-82-1 | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| CSN10636 | Cidofovir | 113852-37-2 | Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. |
| CSN12631 | Chlorambucil | 305-03-3 | Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia. |
| CSN10592 | Cefuroxime | 55268-75-2 | Cefuroxime is a second-generation variety of cephalosporins with less susceptibility to beta-lactamase |
| CSN20655 | CBL0137 | 1197996-80-7 | CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-B and promoting cancer cell death. |
| CSN12816 | Bromodeoxyuridine | 59-14-3 | Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA. |
| CSN16976 | BMH-21 | 896705-16-1 | BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I Pol I transcription and does not cause phosphorylation of H2AX |
| CSN10472 | Bleomycin Sulfate | 9041-93-4 | Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle. |
| CSN10391 | Bendamustine HCl | 3543-75-7 | Bendamustine HCl is a DNA-damaging agent with IC50 of 50 M. |
| CSN16813 | Beaucage Reagent | 66304-01-6 | Beaucage Reagent is potent in causing DNA cleavage. |
| CSN18126 | BCX 4430 HCl | 222631-44-9 | BCX 4430 HCl is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| CSN16282 | BCX 4430 Free Base | 249503-25-1 | BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| CSN18231 | BAY 57-1293 | 348086-71-5 | BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex. |
| CSN18759 | Ancitabine HCl | 10212-25-6 | Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
| CSN18264 | A2AR-Agonist-1 | 41552-95-8 | A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1. |
| CSN23866 | 8-Chloroadenosine | 34408-14-5 | 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis. |
| CSN10160 | 6-Thio-dG | 789-61-7 | 6-Thio-dG is a nucleoside analog and telomerase substrate. |
| CSN12836 | 6-Mercaptopurine Monohydrate | 6112-76-1 | 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. |
| CSN19496 | 5-Fluorouracil | 51-21-8 | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| CSN18758 | 2'-Deoxycytidine HCl | 3992-42-5 | 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. |
| CSN10073 | Blasticidin S HCl | 3513-03-9 |
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