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DNA/RNA Synthesis

DNA/RNA Synthesis

Cat. No. Product Name CAS No. Information
CSN10257 α-Amanitin 23109-05-9 α-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
CSN16911 YK-4-279   1037184-44-3 YK 4-279 is a potent inhibitor of RNA Helicase A RHA that binding to the oncogenic transciption factor EWS-FLI1
CSN16802 Vidarabine   5536-17-4 Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses.
CSN13562 Triapine   143621-35-6 Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.
CSN21982 Tetrahydrouridine 18771-50-1 Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA).
CSN12039 Tegafur   17902-23-7 Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers.
CSN21983 Lonsurf 733030-01-8 TAS-102 is an oral combination drug consisting of trifluridine (FTD), which is a thymidine-based nucleoside analog, and tipiracil HCl (TPI), which improves the bioavailability of FTD by inhibiting its catabolism by thymidine phosphorylase (TP).
CSN15712 Sofosbuvir   1190307-88-0 Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection.
CSN19950 Saikosaponin C 20736-08-7 Saikosaponin C, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant, anti-inflammatory and cytotoxic activities, has an inhibitory activity against allergic asthma. It also shows an inhibitory for cell growth and DNA synthesis with 50-gmL.
CSN11845 Rifaximin   80621-81-4 Rifaximin is an RNA synthesis inhibitor by binding the subunit of the bacterial DNA-dependent RNA polymerase used to treat travelers diarrhea caused by certain bacteria
CSN11844 Rifapentine   61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN19455 Panaxadiol 19666-76-3 Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C.
CSN19697 Nitrobenzylthioinosine 38048-32-7 Nitrobenzylthioinosine is an inhibitor of Equilibrative Nucleoside Transporter 1 (ENT1).
CSN21764 Nitracrine 4533-39-5 Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. 
CSN16103 Nelarabine 121032-29-9 Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 M in tumor cells.
CSN11454 Mizoribine   50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN16113 Hydroxyurea   127-07-1 Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CSN11136 Halofuginone 55837-20-2 Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF- signaling at 10 ngmL in mammal.
CSN11086 Gemcitabine   95058-81-4 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN10050 Folic Acid   59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN10528 Fludarabine   21679-14-1 Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
CSN16461 Fludarabine Phosphate   75607-67-9 Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
CSN18715 Floxuridine   50-91-9 Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 M for the inhibition of PEPT1.
CSN17043 Fidaxomicin   873857-62-6 Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
CSN14493 Euscaphic Acid 53155-25-2 Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
CSN10080 Dacarbazine   4342-03-4 Dacarbazine is an antineoplastic agent with significant activity against melanomas, by acting as an alkylating agent and inhibiting DNA synthesis as a purine analog
CSN24306 Cytidine 65-46-3 Cytidine is a non-essential aminoacid.
CSN19369 Cytarabine   147-94-4 Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.
CSN18773 CRT0044876   6960-45-8 CRT0044876 is a potent and selective APE1 inhibitor with IC50 of 3 M.
CSN10693 Cordycepin   73-03-0 Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent Cordycepin inhibits growth of various tumor cells in vitro It can be converted to 3-deoxyadenosine triphosphate 3-dATP which inhibits ATP-dependent DNA synthesis Cordycepin is also useful for the study of messenger RNA transcription
CSN10636 Cidofovir 113852-37-2 Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
CSN12631 Chlorambucil   305-03-3 Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia.
CSN20655 CBL0137 1197996-80-7 CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-B and promoting cancer cell death.
CSN12816 Bromodeoxyuridine   59-14-3 Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA.
CSN10472 Bleomycin Sulfate 9041-93-4 Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle.
CSN10073 Blasticidin S HCl 3513-03-9 Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA.
CSN10391 Bendamustine HCl 3543-75-7 Bendamustine HCl is a DNA-damaging agent with IC50 of 50 M.
CSN16813 Beaucage Reagent   66304-01-6 Beaucage Reagent is potent in causing DNA cleavage.
CSN18126 BCX 4430 HCl 222631-44-9 BCX 4430 HCl is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN16282 BCX 4430 Free Base 249503-25-1 BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN18231 BAY 57-1293 348086-71-5 BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
CSN18759 Ancitabine HCl   10212-25-6 Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
CSN18264 A2AR-Agonist-1 41552-95-8 A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.
CSN23866 8-Chloroadenosine 34408-14-5 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis.
CSN10160 6-Thio-dG 789-61-7 6-Thio-dG is a nucleoside analog and telomerase substrate.
CSN12836 6-Mercaptopurine Monohydrate   6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN19496 5-Fluorouracil   51-21-8 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
CSN18758 2'-Deoxycytidine HCl 3992-42-5 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
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