DNA-dependent Protein Kinase | DNA Damage|PI3K/Akt/mTOR| CSNpharm

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Anti-infection Antibacterial Antifungal Antiparasitic CMV Filovirus HBV HCV HIV HIV Integrase HIV Protease HRV HSV Influenza Virus NNRTI NRTI Orthopoxvirus Reverse Transcriptase RSV SARS-CoV CCR Dengue Virus H37Rv HHV LpxC Neuraminidase NS2B-NS3 Protease Prion SQLE Antiviral β-lactamase 3CLpro M2 proton channel Antiprotozoal FIP Viral MTase
Apoptosis Apoptosis Inducer Bcl-2 Caspase c-Myc c-RET DAPK IAP MDM2 p53 PD-1/PD-L1 PERK PKD Survivin Thymidylate Synthase TNF-alpha
Autophagy Autophagy CXCR LRRK2 ULK SPHK PPT mitoNEET TFEB
Cell Cycle APC Aurora Kinase Casein Kinase CDK Chk c-Myc CRISPR/Cas9 CRM1 DHFR DNA/RNA Synthesis DUB DYRK eIF G-quadruplex Haspin Kinase HSP IRE1 Kinesin LIMK Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PD-1/PD-L1 PERK PLK PPAR PTEN RAD51 Rho ROCK Wee1 BUB HSF Mad2 p21 E1/E2/E3 Enzyme FOXM1 MKLP TACC
Cytoskeleton Akt Bcr-Abl Dynamin FAK Gap Junction Protein HSP Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK Wnt β-catenin Selectin Arp2/3 Complex PKC Spastin MLCK TACC
DNA Damage ATM/ATR DNA/RNA Synthesis DNA Alkylator/Crosslinker DNA-PK HDAC MTH1 PARP Sirtuin Telomerase Topoisomerase OGG ATAD5
Endocrinology/Hormones 5 alpha Reductase ACE Androgen Receptor Aromatase ERR Glucocorticoid Receptor GPCR Opioid Receptor Progesterone Receptor Renin TPO TRHR Thyroid Hormone Receptor
Epigenetics AMPK Aurora Kinase CECR2 DNA Methyltransferase Epigenetic Reader Domain HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK microRNA PAD PARP Pim PKC Sirtuin TET
GPCR/G Protein Adenosine Receptor Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRTH2 CXCR Dopamine Receptor Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor Guanylate Cyclase Hedgehog Histamine Receptor Imidazoline Receptor LPA Receptor LTR mGluR Motilin Receptor MT Receptor Neurotensin Receptor NK Receptor NMUR Opioid Receptor OX Receptor OXTR P2Y Receptor PAFR PAR PKA Prostaglandin Receptor Ras RGS SGLT Sigma Receptor SSTR TSH Receptor Urotensin Receptor Vasopressin Receptor HDR More >>
Immunology/Inflammation CCR Complement System COX CRTH2 CXCR FLAP Histamine Receptor IFNAR IL Receptor IRAK LTR MALT1 NADPH Oxidase NLR NOS Nrf2 PD-1/PD-L1 PGE Synthase ROS SIK STING Thrombopoietin Receptor TLR Calcineurin Complement Receptor IL IRF3 MIF S100A9 TSPO cGAS Immunology & Inflammation Related LTA4H MYD88 NFAT FPR
JAK/STAT Signaling EGFR JAK Pim STAT
LIF/Stat3 LIF
MAPK/ERK Pathway ERK JNK KLF MEK MLK MNK p38 MAPK Raf RSK Cot/tpl2 MAP3K12 MAP4K4 AP-1
Membrane Transporter/Ion Channel AMPAR BCRP CFTR Chloride Channel CRAC Channel CRM1 EAAT2 HCN Channel MAT MCT Na+/Ca2+ Exchanger NKCC P2X Receptor P-gp Potassium Channel Proton Pump Sodium Channel TRPV URAT1 VDAC GABA Receptor IBAT Oct SGLT AChR ATPase Calcium Channel EAAT1 GlyT1 Na+/K+ ATPase NBC NMDAR TRP Channel SLC PIEZO1 UCP ENT GABA transporter Glycine transporter Kainate receptor ABC Transporter
Metabolic Enzyme 15-PGDH ACC ACE Adenosine Deaminase Adenosine Kinase AhR ALDH Aldose Reductase Aminopeptidase ATP Citrate Lyase Carbonic Anhydrase Cathepsin CETP COMT CPA Decarboxylase Dehydrogenase DGAT DHFR Elastase Enolase FAAH FABP Factor Xa FAS Ferroptosis FXR Glucokinase GLUT1 GSNOR GST Hexokinase HIF HIV Integrase HMGCR HSP Hydroxylase IDH IDO Lipase Lipoxygenase LXR MAO Mineralocorticoid Receptor NAE NAMPT Neprilysin P450 PAI-1 More >>
Neuronal Signaling AChE Adenosine Kinase Adrenergic Receptor AMPAR Amyloid-β CaMK CGRP Receptor COMT COX DAT Dopamine Receptor FAAH GABA Receptor GlyT1 Histamine Receptor Imidazoline Receptor MAO mGluR MT Receptor NK Receptor NMDAR Opioid Receptor OX Receptor P2X Receptor P-gp Secretase SSRIs Substance P Choline Cholinesterase Enkephalinase Glucosylceramide Synthase NET PSD-95 RAGE SERT 5-HT Receptor AChR PIEZO1 Proprotein convertases QC AQP4 CHT GABA transporter Glycine transporter Kainate receptor
PI3K/Akt/mTOR Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN RSK FOXO PHLPP
Protease Caspase Cysteine Protease DPP4 Glutaminase HIV Protease MMP Proteasome Secretase Ser/Thr Protease NEP PE Aspartic Protease Tyrosinase DPP2
Protein Tyrosine Kinase/RTK Ack1 ALK Bcr-Abl BMX Kinase BTK c-FMS c-Kit c-Met/HGFR c-RET DDR1/DDR2 Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 HER2 IGF-1R Insulin Receptor ITK PDGFR PKA PTK Pyk2 Src Syk TAM Receptor Tie-2 Trk Receptor VEGFR BRK FGF Tec
Stem Cells/Wnt Casein Kinase ERK Gli GSK-3 Hedgehog JAK MST Notch PKA PORCN ROCK Secretase sFRP-1 Smo STAT Wnt YAP β-catenin BMI-1 TGF-beta Receptor CREB Hes1
TGF-beta/Smad TGF-beta Receptor Smad TGF-beta Smurf
Phosphatase
Ubiquitin APC DUB NAE p97 Proteasome E1/E2/E3 Enzyme SUMO
NF-κB HDAC IKK MALT1 NF-κB NOD1 Nrf2 PPAR RIP Kinase TAK1
Biochemical Reagent Intermediate and Others Biochemical Assay Reagent Dye Reagent
Others Phosphatase SRPK Cardiolipin Peroxidase Diuretic DUE-B E2F ECE FANCJ FAP Fer/FerT Fucosyltransferase Galectin-3 GBF1 GCase HIPK2 HPPD Insecticide LAT1 MLKL MPO MPTP MTP MTTP NMD NO Synthesis Nur77 PAX2 PBR PCA1 PCSK9 PDX1 PFKFB3 Phosphorylase PIN1 PKG Platelet Protein Synthesis Rev-ErbA SAP Serine Hydrolase SQS SREBP STK33 Sweetener Tgase TIR1 UGT1A1 Urease Vanin More >>
PROTAC E1/E2/E3 Enzyme Others

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DNA-PK

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DNA-PK

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Cat. No.	Product Name	CAS No.	Information
CSN18247	PIK-75	372196-77-5	PIK-75 is a selective p110 inhibitor with IC50 of 58 nM with 200-fold more potently than p110 and also potently inhibits DNA-PK with IC50 of 2 nM
CSN15991	NU7441	503468-95-9	NU7441 is a potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 M in cell-free assays
CSN16116	NU7026	154447-35-5	NU7026 is a potent and selective inhibitor of DNA-PK with IC50 of 023 M
CSN19819	NU-7200	842122-14-9	NU-7200 is a potent DNA-PK inhibitor with potential anticancer activity
CSN19818	NU-7199	69541-04-4	NU-7199 is a potent DNA-PK inhibitor with potential anticancer activity
CSN19817	NU-7031	79105-88-7	NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity
CSN21097	M3814	1637542-33-6	M-3814, also known as MSC2490484A and nedisertib, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities.
CSN22555	LTURM34	1879887-96-3	LTURM34 shows potent inhibition of DNA-PK IC50 0034 M with excellent selectivity over the Class I PI3K isoforms IC50 all 5 M and inhibits the proliferation of a wide range of tumor cell lines
CSN22790	DMNB	20357-25-9	DMNB is a volatile organic compound used as a detection taggant for explosives.
CSN17373	Compound 401	168425-64-7	Compound 401 is a DNA-PK synthetic inhibitor with IC50 of 028 M also targets mTOR
CSN17592	CC-115	1228013-15-7	CC-115 is an inhibitor of mTOR and DNA-PK with IC50 of 21 and 13 nM respectively
CSN17666	CC-115 HCl	1300118-55-1	CC-115 HCl is an inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
CSN10521	Brivudine	69304-47-8	Brivudine is an antiviral drug acts by inhibiting replication of the target virus used in the treatment of Herpes Zoster
CSN24702	AZD7648	2230820-11-6	AZD7648 is a highly potent and selective DNA-PK inhibitor with IC50 value of 92nM.

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