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DNA Methyltransferase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12234 | Zebularine | 3690-10-6 | Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM. |
| CSN15868 | SGI-1027 | 1020149-73-8 | SGI-1027 is a potent and selective inhibitor of DNA methyltransferase DNMT with IC50 of 6 8 75 M for DNMT1 DNMT3A and DNMT3B respectively |
| CSN16078 | RG108 | 48208-26-0 | RG108 is a DNA methyltransferase inhibitor with IC50 of 115 nM |
| CSN18251 | O6BTG-octylglucoside | 382607-78-5 | O6BTG-C8-Glu is a glucose-conjugated MGMT inhibitor with IC50 values of 32 nM in vitro and 10 nM on HeLa S3 cell and the parent compound O6BTGs IC50 is 9 nM in vitro |
| CSN11506 | N-Acetylprocainamide | 32795-44-1 | N-Acetylprocainamide is the N-acetylated metabolite of Procainamide and is a Class III antiarrhythmic agent |
| CSN15937 | Lomeguatrib | 192441-08-0 | Lomeguatrib an inhibitor of DNA repair protein O6-methylguanine-DNA methyltransferase MGMT with IC50 of 0009 M in cell-free extracts from HeLa S3 cells is a modified guanine base |
| CSN12608 | Decitabine | 2353-33-5 | Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| CSN13714 | 6-Thioguanine | 154-42-7 | 6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. 6-Thioguanine disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. |
| CSN25528 | 5-Fluoro-2'-deoxycytidine | 10356-76-0 | 5−Fluoro−2'−deoxycytidine is a DNMT inhibitor which forms covalent links with the cysteine residue in the DNMT active site. |
| CSN19354 | 5-Azacytidine | 320-67-2 | 5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
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