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DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

Cat. No. Product Name CAS No. Information
CSN10789 VAL-083 23261-20-3 VAL-083 is a bi-functional alkylating agent and inhibits U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
CSN12131 Treosulfan 299-75-2 Treosulfan is an alkylating agent used for conventional as well as high-dose chemotherapy regimens whereby plasma concentrations over 500 gmL can be achieved
CSN12081 Thio-TEPA   52-24-4 Thio-TEPA is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.
CSN12046 Temozolomide   85622-93-1 Temozolomide is a DNA-methylating agent and an alkylating cytostatic drug used in the treatment of some brain cancers, astrocytoma and glioblastoma multiforme.
CSN11987 Streptozocin   18883-66-4 Streptozocin is a potent DNA alkylator with antitumor effects, also used to induce diabete model.
CSN13611 SJG-136 232931-57-6 SJG-136 is a rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.
CSN20052 Seco-Duocarmycin TM 236102-87-7 Seco-duocarmycin TM is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN20047 Seco-Duocarmycin SA 144667-38-9 Seco-duocarmycin SA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN20051 Seco-Duocarmycin MB 1613286-58-0 Seco-duocarmycin MB is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN20046 Seco-Duocarmycin MA 1613286-57-9 Seco-duocarmycin MA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN10459 Satraplatin 129580-63-8 Satraplatin is a platinum-based antineoplastic agent that is under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy.
CSN15939 RITA 213261-59-7 RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks
CSN20037 Pyrrolobenzodiazepine Dimer 1222490-34-7 Pyrrolobenzodiazepine dimer (PDB dimer) is a DNA crosslinking agent that inhibits DNA synthesis.
CSN11776 Procarbazine HCl   366-70-1 Procarbazine HCl an antineoplastic chemotherapy drug is an alkylating agent for the treatment of Hodgkins lymphoma and certain brain cancers and also inhibits MAO thus increasing the effects of sympathomimetics TCAs and tyramine
CSN11496 Palifosfamide 31645-39-3 Palifosfamide is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS).
CSN11626 Oxaliplatin   61825-94-3 Oxaliplatin inhibits DNA synthesis by conforming DNA adducts
CSN11530 Nedaplatin   95734-82-0 Nedaplatin is a derivative of cisplatin and DNA damage agent
CSN18156 Miriplatin Hydrate 250159-48-9 Miriplatin is approved for lipiodolization for the treatment of hepatocellular carcinoma and it is a lipophilic platinum complex containing myristates as leaving groups and can be easily suspended in ethyl esters of iodized fatty acids obtained from poppy seed oil
CSN16956 Miriplatin   141977-79-9 Miriplatin is a platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma HCC
CSN11325 Lomustine 13010-47-4 Lomustine is an alkylating nitrosourea compound used in chemotherapy. Lomustine (420 M) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
CSN20587 Lobaplatin 135558-11-1 Lobaplatin is a diastereometric mixture of platinumII complexes containing a 12-bisaminomethylcyclobutane stable ligand and lactic acid as the leaving group Its antitumour activity results from the formation of DNA-drug adducts mainly as GG and AG intra-strand cross-links
CSN20036 Irofulven 158440-71-2 Irofulven is a DNA alkylator agent that inhibits DNA synthesis
CSN16324 Ifosfamide   3778-73-2 Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
CSN19811 Heptaplatin (Sunpla) 146665-77-2 Heptaplatin is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines.
CSN11053 Fotemustine 92118-27-9 Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma
CSN20040 Esperamicin A1 99674-26-7 Esperamicin A1 is a DNA crosslinking agent that inhibits DNA synthesis
CSN20049 Duocarmycin SA 130288-24-3 Duocarmycin SA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN20050 Duocarmycin B1 124325-93-5 Duocarmycin B1 is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN20045 Duocarmycin A 118292-34-5 Duocarmycin A is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN10722 Cyclofosphamide 50-18-0 Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
CSN10657 Cisplatin   15663-27-1 Cisplatin is an inorganic platinum complex which is able to inhibit DNA synthesis by conforming DNA adducts It is used alone or in combination therapy in the treatment of several types of cancer including testicular ovarian cervical bladder and lung cancers Cisplatin also inhibits the RecA recombinase of M tuberculosis IC50 2 M blocking protein splicing and cell growth
CSN20048 CC-1065 69866-21-3 CC-1065 is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis
CSN21213 CB 1954 21919-05-1 CB 1954 is an anticancer prodrug used in gene therapy research and is activated by NADPH Quinone Oxidoreductase 2
CSN17085 Carmustine   154-93-8 Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
CSN10551 Carboplatin   41575-94-4 Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cells repair mechanism.
CSN17448 Calicheamicin 108212-75-5 Calicheamicin is a potent DNA crosslinker cytotoxic antibiotic.
CSN10512 Busulfan   55-98-1 Busulfan is a bifunctional alkylating agent
CSN18706 Altretamine   645-05-6 Altretamine is an alkylating agent proposed as an antineoplastic.
CSN18190 Altretamine HCl 2975-00-0 Altretamine hydrochloride is an alkylating agent proposed as an antineoplastic.
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