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DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

Cat. No. Product Name CAS No. Information
CSN12081 Thio-TEPA   52-24-4 Thio-TEPA is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.
CSN12046 Temozolomide   85622-93-1 Temozolomide is a DNA-methylating agent and an alkylating cytostatic drug used in the treatment of some brain cancers, astrocytoma and glioblastoma multiforme.
CSN15939 RITA 213261-59-7 RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks
CSN11776 Procarbazine HCl   366-70-1 Procarbazine HCl an antineoplastic chemotherapy drug is an alkylating agent for the treatment of Hodgkins lymphoma and certain brain cancers and also inhibits MAO thus increasing the effects of sympathomimetics TCAs and tyramine
CSN16956 Miriplatin   141977-79-9 Miriplatin is a platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma HCC
CSN11325 Lomustine 13010-47-4 Lomustine is an alkylating nitrosourea compound used in chemotherapy. Lomustine (420 M) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
CSN16324 Ifosfamide   3778-73-2 Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
CSN10722 Cyclofosphamide 50-18-0 Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
CSN10657 Cisplatin   15663-27-1 Cisplatin is an inorganic platinum complex which is able to inhibit DNA synthesis by conforming DNA adducts It is used alone or in combination therapy in the treatment of several types of cancer including testicular ovarian cervical bladder and lung cancers Cisplatin also inhibits the RecA recombinase of M tuberculosis IC50 2 M blocking protein splicing and cell growth
CSN21213 CB 1954 21919-05-1 CB 1954 is an anticancer prodrug used in gene therapy research and is activated by NADPH Quinone Oxidoreductase 2
CSN17085 Carmustine   154-93-8 Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
CSN10551 Carboplatin   41575-94-4 Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cells repair mechanism.
CSN10512 Busulfan   55-98-1 Busulfan is a bifunctional alkylating agent
CSN18706 Altretamine   645-05-6 Altretamine is an alkylating agent proposed as an antineoplastic.
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