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DNA Alkylator/Crosslinker
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN10789 | VAL-083 | 23261-20-3 | VAL-083 is a bi-functional alkylating agent and inhibits U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis. |
| CSN12131 | Treosulfan | 299-75-2 | Treosulfan is an alkylating agent used for conventional as well as high-dose chemotherapy regimens whereby plasma concentrations over 500 gmL can be achieved |
| CSN12081 | Thio-TEPA | 52-24-4 | Thio-TEPA is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate. |
| CSN12046 | Temozolomide | 85622-93-1 | Temozolomide is a DNA-methylating agent and an alkylating cytostatic drug used in the treatment of some brain cancers, astrocytoma and glioblastoma multiforme. |
| CSN13611 | SJG-136 | 232931-57-6 | SJG-136 is a rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. |
| CSN20052 | Seco-Duocarmycin TM | 236102-87-7 | Seco-duocarmycin TM is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN20047 | Seco-Duocarmycin SA | 144667-38-9 | Seco-duocarmycin SA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN20051 | Duocarmycin MB | 1613286-58-0 | Seco-duocarmycin MB is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN20046 | Duocarmycin MA | 1613286-57-9 | Seco-duocarmycin MA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN10459 | Satraplatin | 129580-63-8 | Satraplatin is a platinum-based antineoplastic agent that is under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. |
| CSN15939 | RITA | 213261-59-7 | RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression. |
| CSN20037 | SGD-1882 | 1222490-34-7 | Pyrrolobenzodiazepine dimer (PDB dimer) is a DNA crosslinking agent that inhibits DNA synthesis. |
| CSN11776 | Procarbazine Hydrochloride | 366-70-1 | Procarbazine HCl an antineoplastic chemotherapy drug is an alkylating agent for the treatment of Hodgkins lymphoma and certain brain cancers and also inhibits MAO thus increasing the effects of sympathomimetics TCAs and tyramine |
| CSN11732 | Pipobroman | 54-91-1 | Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. |
| CSN11496 | Palifosfamide | 31645-39-3 | Palifosfamide is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS). |
| CSN11626 | Oxaliplatin | 61825-94-3 | Oxaliplatin inhibits DNA synthesis by conforming DNA adducts |
| CSN11530 | Nedaplatin | 95734-82-0 | Nedaplatin is a derivative of cisplatin and DNA damage agent |
| CSN29493 | MTIC | 3413-72-7 | MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide. |
| CSN18156 | Miriplatin (hydrate) | 250159-48-9 | Miriplatin is approved for lipiodolization for the treatment of hepatocellular carcinoma and it is a lipophilic platinum complex containing myristates as leaving groups and can be easily suspended in ethyl esters of iodized fatty acids obtained from poppy seed oil |
| CSN16956 | Miriplatin | 141977-79-9 | Miriplatin is a platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma HCC |
| CSN11325 | Lomustine | 13010-47-4 | Lomustine is an alkylating nitrosourea compound used in chemotherapy. Lomustine (420 M) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells. |
| CSN20587 | Lobaplatin | 135558-11-1 | Lobaplatin is a diastereometric mixture of platinumII complexes containing a 12-bisaminomethylcyclobutane stable ligand and lactic acid as the leaving group Its antitumour activity results from the formation of DNA-drug adducts mainly as GG and AG intra-strand cross-links |
| CSN20036 | (-)-Irofulven | 158440-71-2 | Irofulven is a DNA alkylator agent that inhibits DNA synthesis |
| CSN28438 | Improsulfan HCl | 3458-22-8 | Improsulfan is an alkylsulfonate alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. |
| CSN16324 | Ifosfamide | 3778-73-2 | Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
| CSN20049 | Duocarmycin SA | 130288-24-3 | Duocarmycin SA is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN20045 | Duocarmycin A | 118292-34-5 | Duocarmycin A is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN10657 | Cisplatin | 15663-27-1 | Cisplatin is an inorganic platinum complex which is able to inhibit DNA synthesis by conforming DNA adducts It is used alone or in combination therapy in the treatment of several types of cancer including testicular ovarian cervical bladder and lung cancers Cisplatin also inhibits the RecA recombinase of M tuberculosis IC50 2 M blocking protein splicing and cell growth |
| CSN20048 | Rachelmycin | 69866-21-3 | CC-1065 is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis |
| CSN21213 | Tretazicar | 21919-05-1 | CB 1954 is an anticancer prodrug used in gene therapy research and is activated by NADPH Quinone Oxidoreductase 2 |
| CSN17085 | Carmustine | 154-93-8 | Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent. |
| CSN10551 | Carboplatin | 41575-94-4 | Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cells repair mechanism. |
| CSN17448 | Calicheamicin | 108212-75-5 | Calicheamicin is a potent DNA crosslinker cytotoxic antibiotic. |
| CSN10512 | Busulfan | 55-98-1 | Busulfan is a bifunctional alkylating agent |
| CSN41276 | Bendamustine | 16506-27-7 | Bendamustine is a DNA cross-linking agent. |
| CSN18706 | Altretamine | 645-05-6 | Altretamine is an alkylating agent proposed as an antineoplastic. |
| CSN18190 | Altretamine hydrochloride | 2975-00-0 | Altretamine HCl is an alkylating agent proposed as an antineoplastic. |
| CSN81353 | Temozolomide acid | 113942-30-6 |
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