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Diterpenoids

Diterpenoids

Cat. No. Product Name CAS No. Information
CSN14237 Villosin 160598-92-5 Villosin, a natural product isolated and purified from the herbs of Hedychium coronarium, shows inhibitory effects against nitric oxide production in LPS and IFN--induced RAW 264.7 murine macrophages with IC50 values of 5.99 1.20 ugmL and exhibits potent cytotoxic activity. It may be used as a potential lead molecule for antitumor therapeutic development.
CSN14785 Triptoquinone B 142937-50-6 Triptoquinone B, a natural product isolated and purified from the vines of Tripterygium wilfordii with immunosuppressive acitivity, is an interleukin-1 inhibitor, showing extremely potent inhibitory activities against interleukin-l and releases for human peripheral mononticlear cells.
CSN14256 Taxinine M 135730-55-1 Taxinine M is a chemotherapy agent isolated and purified from the seeds of Chinese yew Taxus chinensis.
CSN14774 Taxinine B 18457-44-8 Taxinine B, a natural product isolated and purified from the barks of Taxus chinensis, can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells, and shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
CSN12034 Tanshinone IIB 17397-93-2 Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.
CSN11984 Stevioside   57817-89-7 Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-B and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IBNF-B signalling pathway.
CSN25589 Rosmariquinone 27210-57-7 Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively.
CSN14234 Przewalskin 119400-87-2 Przewalskin is a natural product isolated and purified from the roots of Salvia miltiorrhiza with antitumor and anti-HIV activities.
CSN14239 Pinusolide 31685-80-0 Pinusolide, a natural potent and specific PAF antagonist isolated and purified from the barks of Biota orientalis L., inhibits 5-lipoxygenase (5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner.
CSN11720 Pimaric Acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN11720 Pimaric Acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN20394 Ovatodiolide 3484-37-5 Ovatodiolide is a macrocyclic diterpenoid isolated from Anisomeles indica, showing therapeutic potential for the treatment of allergic asthma.
CSN19419 Oridonin   28957-04-2 Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens.
CSN15611 Neoprzewaquinone A 630057-39-5 Neoprzewaquinone A, a natural product isolated and purified from the roots of Salvia miltiorrhiza, has algicidal effect on M.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN14796 Nagilactone B 19891-51-1 Nagilactone B, a natural product isolated and purified from the herbs of Podocarpus neriifolius, selectively activates LXR in macrophages and induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics.
CSN15324 Kongensin A 885315-96-8 Kongensin A, a natural product isolated and purified from the herbs of Croton cascarilloides, is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
CSN14103 Kaurenoic Acid 6730-83-2 Kaurenoic Acid is a natural product isolated and purified from the herbs of Croton antisyphiliticus with anti-inflammatory property, the mechanisms may through inhibition of iNOS and COX-2 expression. Kaurenoic acid is an inducer of apoptosis, which is part of the innate mechanism of cell defense against neoplasia. Kaurenoic acid from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans.
CSN19405 Honokiol   35354-74-6 Honokiol inhibits Akt activation and enhances ERK1ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.
CSN11864 Gum Rosin 8050-09-7 Gum rosin and wood rosin in Tako-no-Suidashi ointment have an effect on allergic contact dermatitis.
CSN19411 Ginkgolide C   15291-76-6 Ginkgolide C can enhance the cardiac function of rats in the body, is a flavone isolated from Ginkgo biloba leaves.
CSN14586 Galanolactone 115753-79-2 Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN16500 Dihydrotanshinone I 87205-99-0 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.
CSN10310 Dehydroandrographolide   134418-28-3 Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees and alleviates oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.
CSN19484 Deacetyltaxol   78432-77-6 Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines.
CSN19905 Crocin II 55750-84-0 Crocin, a natural product with anti-inflammatory, antihyperlipidemic, antidepressant and anti-apoptotic effects, can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite, its isolated and purified from the stigma of Crocus sativus L..
CSN16599 Crocin 42553-65-1 Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
CSN14238 Coronarin D 119188-37-3 Coronarin D, a natural product isolated and purified from the rhizomes of Hedychium coronarium, inhibits NF-κB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.
CSN14781 Coronarin A 119188-33-9 Coronarin A, a natural product isolated and purified from the rhizomes of Hedychium coronarium with anti-inflammatory activity, exhibits good growth inhibition activities on HUVEC proliferation.
CSN10554 Carnosol 5957-80-2 Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 M.
CSN20512 Cafestol 469-83-0 Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses.
CSN13458 Bruceine D 21499-66-1 Bruceine D, a natural product isolated and purified from the barks of Ailanthus altissima, may have the potential to be used as a natural viricide, or a lead compound for viricides, inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1, and induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.
CSN14021 Baccatin VI 57672-79-4 Baccatin VI, a taxane derivative isolated and purified from the the heartwood from Taxus mairei, is a neoplasm inhibitor to ovarian and breast cancers.
CSN15373 Aphadilactone C 1522004-70-1 Aphadilactone C is a naturla product isolated and purified from Aphanamixis grandifolia with DGAT inhibitory and antimalarial activities.
CSN15374 Aphadilactone B 1522004-68-7 Aphadilactone B is a naturla product isolated and purified from Aphanamixis grandifolia with DGAT inhibitory and antimalarial activities.
CSN15042 Adenanthin 111917-59-0 Adenanthin, a natural product isolated and purified from the herb of Rabdosia adenantha with antiinflammatory, antitumour, bacteriostatic, and antileukemic activities, is an NF-B and nucleophilic cysteines inhibitor, and can serve as the development of Prx I and Prx IItargeted therapeutic agents.
CSN10195 Abietic Acid 514-10-3 Abietic acid is a PPAR dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-B and the MAPKAP-1 pathway, its a natural product isolated and purified from the herbs of Pinus massoniana which can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis.
CSN15049 Abiesadine N 1159913-80-0 Abiesadine N is a natural product isolated and purified from the barks of Pinus yunnanensis.
CSN13216 8alpha-Hydroxylabda-13(16),14-Dien-19-Yl p-Hydroxycinnamate 117254-98-5 8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate is a natural product isolated and purified from the herbs of Metasequoia glyptostroboides.
CSN13461 7-Epitaxol   105454-04-4 7-Epitaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. which is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
CSN14257 7-Epi 10-Desacetyl Paclitaxel 78454-17-8 7-Epi 10-desacetyl paclitaxel is a paclitaxel impurity. The compound, originally isolated from Taxus yunnanensis, has shown potential growth inhibitory activities against human cancer cells.
CSN15356 6alpha-Hydroxycleroda-3,13-Dien-16,15-Olid-18-Oic Acid 771493-42-6 6alpha-hydroxycleroda-3,13-dien-16,15-olid-18-oic acid is an alpha- glucosidase inhibitory constituent from Duranta repens, and is one alpha- glucosidase inhibitory constituent from Duranta repens.
CSN14248 Euphorbia Factor L3 218916-52-0 5,15-Diacetyl-3-benzoyllathyrol, a natural product isolated and purified from the seeds of Euphorbia lathyris L., is one of the lathyrane diterpenoids with anti-cancer activity.
CSN14783 15-Methoxypinusolidic Acid 769928-72-5 15-Methoxypinusolidic acid, a natural product isolated and purified from the leaves of Biota orientalis, induces apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression, inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression, and attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.
CSN14100 15-Hydroxydehydroabietic Acid 54113-95-0 15-Hydroxydehydroabietic acid is a natural product isolated and purified from the branch of Platycladus orientalis with a promising alpha-glucosidase inhibitory and significant antibacterial activities.
CSN19770 14-Deoxyandrographolide 4176-97-0 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
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