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DHFR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16458 | Trimethoprim | 738-70-5 | Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections. |
| CSN12806 | Pyrimethamine | 58-14-0 | Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. |
| CSN21745 | Proguanil | 500-92-5 | Proguanil is an inhibitor of dihydrofolate reductase (DHFR). It is antimalarial prodrug metabolized to the active metabolite cycloguanil. |
| CSN13592 | Pralatrexate | 146464-95-1 | Pralatrexate is an antifolate and structurally a folate analog Its IC50 is 300 nM in some cell lines |
| CSN11667 | Pemetrexed | 137281-23-3 | Pemetrexed is an antifolate and antimetabolite for TSthymidylate synthase DHFRdihydrofolate reductase and GARFTglycinamide ribonucleotide formyltransferase with Ki of 13 nM 72 nM and 65 nM respectively |
| CSN11667 | Pemetrexed | 137281-23-3 | Pemetrexed is an antifolate and antimetabolite for TSthymidylate synthase DHFRdihydrofolate reductase and GARFTglycinamide ribonucleotide formyltransferase with Ki of 13 nM 72 nM and 65 nM respectively |
| CSN12796 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| CSN16714 | Pemetrexed disodium | 150399-23-8 | Pemetrexed Disodium is an antifolate and antimetabolite for TS DHFR and GARFT with Ki of 13 nM 72 nM and 65 nM respectively |
| CSN12754 | Pemetrexed disodium heptahydrate | 357166-29-1 | Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase. |
| CSN16844 | Methotrexate | 59-05-2 | Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. |
| CSN22453 | LY309887 | 127228-54-0 | LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase GARFT with a Ki of 65 nM and has antitumor activity |
| CSN22451 | LY 222306 | 154446-98-7 | LY 222306 is a glycinamide ribonucleotide formyltransferase GARFT inhibitor with a Ki of 077 nM |
| CSN26629 | Lometrexol hydrate | 1435784-14-7 | Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2]. |
| CSN12983 | Levomefolic acid | 31690-09-2 | Levomefolic acid is the natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions |
| CSN12982 | Levomefolate calcium | 151533-22-1 | Levomefolate Calcium is an artificial form of folate |
| CSN12564 | Folinic acid calcium | 1492-18-8 | Leucovorin calcium is a reduced form of folic acid |
| CSN21969 | Iclaprim | 192314-93-5 | Iclaprim is a new selective bacterial dihydrofolate reductase inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL. |
| CSN10090 | Folinic acid | 58-05-9 | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate |
| CSN11049 | Folinic acid calcium salt pentahydrate | 6035-45-6 | Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs. |
| CSN21604 | Diaveridine | 5355-16-8 | Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent. |
| CSN23284 | Diaveridine HCl | 2507-23-5 | Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase It can prevente folic acid synthesis in species of Pneumocystis Diaveridine also has genotoxicity |
| CSN23377 | Cycloguanil hydrochloride | 152-53-4 | Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor. |
| CSN12746 | Calcium N5-methyltetrahydrofolate | 26560-38-3 | Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers |
| CSN10527 | Levoleucovorin Calcium | 80433-71-2 | Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid. |
| CSN22341 | Pelitrexol | 446022-33-9 | AG 2037 Pelitrexol is an inhibitor of glycinamide ribonucleotide formyltransferase GARFT |
| CSN26146 | 1-(4-Chlorophenyl)biguanide hydrochloride | 4022-81-5 | 1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit dihydrofolate reductase (DHFR). |
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