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DHFR

DHFR

Cat. No. Product Name CAS No. Information
CSN16458 Trimethoprim   738-70-5 Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.
CSN12806 Pyrimethamine   58-14-0 Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid.
CSN13592 Pralatrexate 146464-95-1 Pralatrexate is an antifolate and structurally a folate analog Its IC50 is 300 nM in some cell lines
CSN11667 Pemetrexed   137281-23-3 Pemetrexed is an antifolate and antimetabolite for TSthymidylate synthase DHFRdihydrofolate reductase and GARFTglycinamide ribonucleotide formyltransferase with Ki of 13 nM 72 nM and 65 nM respectively
CSN12796 Pemetrexed Disodium Hydrate 357166-30-4 Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16714 Pemetrexed Disodium   150399-23-8 Pemetrexed Disodium is an antifolate and antimetabolite for TS DHFR and GARFT with Ki of 13 nM 72 nM and 65 nM respectively
CSN16844 Methotrexate   59-05-2 Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
CSN22453 LY309887 127228-54-0 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase GARFT with a Ki of 65 nM and has antitumor activity
CSN22451 LY 222306 154446-98-7 LY 222306 is a glycinamide ribonucleotide formyltransferase GARFT inhibitor with a Ki of 077 nM
CSN12983 Levomefolic Acid 31690-09-2 Levomefolic acid is the natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions
CSN12982 Levomefolate Calcium 151533-22-1 Levomefolate Calcium is an artificial form of folate
CSN12564 Calcium Folinate 1492-18-8 Leucovorin calcium is a reduced form of folic acid
CSN10090 Folinic Acid 58-05-9 Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate
CSN11049 Folinic Acid Calcium Pentahydrate   6035-45-6 Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.
CSN21604 Diaveridine   5355-16-8 Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent.
CSN23284 Diaveridine HCl   2507-23-5 Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase It can prevente folic acid synthesis in species of Pneumocystis Diaveridine also has genotoxicity
CSN23377 Cycloguanil HCl   152-53-4 Cycloguanil HCl is hydrochloride form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor
CSN12746 Calcium N5-methyltetrahydrofolate   26560-38-3 Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
CSN10527 Calcium Levofolinate 80433-71-2 Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid.
CSN22341 AG 2037 446022-33-9 AG 2037 Pelitrexol is an inhibitor of glycinamide ribonucleotide formyltransferase GARFT
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