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Dehydrogenase

Dehydrogenase

Cat. No. Product Name CAS No. Information
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN29529 11beta-Hydroxyprogesterone 600-57-7 The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
CSN13699 Teriflunomide   163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN11548 Teriflunomide(Random Configuration)   108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN23145 TC HSD 21 330203-01-5 TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].
CSN22561 Sodium 2,2-dichloroacetate   2156-56-1 Sodium 22-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase PDK with IC50s of 183 and 80 M for PDK2 and PDK4 respectively with tumor growth inhibition properties
CSN22557 RRx-001   925206-65-1 RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase G6PD
CSN26191 2-Allyl-1-hydroxy-9,10-anthraquinone 64302-87-0 R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth.
CSN22939 (R)-GNE-140 2003234-63-5 R-GNE-140 is a potent lactate dehydrogenase A LDHA inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively
CSN24124 Pyrazinecarboxylic acid 98-97-5 Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.
CSN21792 Phenylglyoxal hydrate   1075-06-5 Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase ALDH binding the arginine residues in purified Hageman factor HF Factor XII and causes inhibition of its coagulant properties
CSN23240 Oxalacetic Acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN19396 Mycophenolic Acid   24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 Mycophenolate Mofetil   128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase III with IC50 of 39 nM and 27 nM, respectively.
CSN19079 ML390 2029049-79-2 ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia
CSN27650 LY345899 10538-99-5 LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM).
CSN16462 Leflunomide   75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 M, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN22446 LDH-IN-1 1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
CSN24832 LDH-A Inhibitor III 1269802-68-7 LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor.
CSN26126 HQNO 341-88-8 HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
CSN28430 GSK2837808A   1445879-21-9 GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells.
CSN19090 GNE-140 Racemate 1802977-61-2 GNE-140 racemate is a LDHA inhibitor
CSN16654 Gimeracil   103766-25-2 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase DPYD which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination
CSN33152 Galloflavin 568-80-9 Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor.
CSN27755 G6PDi-1 2457232-14-1 G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM.
CSN27625 FX11 213971-34-7 FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM.
CSN19521 Fomepizole   7554-65-6 Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol
CSN27658 DHODH-IN-11   1263303-95-2 DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.
CSN20383 Crocetin 27876-94-4 Crocetin a saffron derivative is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer
CSN15809 CPI-613   95809-78-2 CPI-613 is an E1 pyruvate dehydrogenase PDH modulator that prevents cancer cells from metabolizing glucose for energy CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer
CSN26336 Chloramphenicol succinate sodium 982-57-0 Chloramphenicol succinate sodium, a prodrug of chloramphenicol, is competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity.
CSN16289 BVT 2733 376640-41-4 BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11-HSD1).
CSN25383 Brequinar sodium 96201-88-6 Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis.
CSN25384 Brequinar 96187-53-0 Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses.
CSN25625 BAY 2402234 2225819-06-5 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
CSN20651 AZD4017 1024033-43-9 AZD4017 is a potent selective and orally bioavailable11-HSD1 inhibitor 11-hydroxysteroid dehydrogenase type 1 inhibitor Inhibition of 11-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome
CSN25633 AZ 33 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP 9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3
CSN23342 3-Methylpyrazole   1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil
CSN27552 2-Bromoacetamide 683-57-8 2-Bromoacetamide can inactivate alcohol dehydrogenase.
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