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Dehydrogenase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18402 | Vidofludimus | 717824-30-1 | Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug. |
| CSN13699 | Teriflunomide | 163451-81-8 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| CSN11548 | (E/Z)-Teriflunomide | 108605-62-5 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| CSN23145 | TC HSD 21 | 330203-01-5 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1]. |
| CSN26191 | R162 | 64302-87-0 | R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth. |
| CSN22939 | (R)-GNE-140 | 2003234-63-5 | R-GNE-140 is a potent lactate dehydrogenase A LDHA inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively |
| CSN24124 | Pyrazinecarboxylic acid | 98-97-5 | Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD. |
| CSN23240 | Oxaloacetic acid | 328-42-7 | Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH. |
| CSN19396 | Mycophenolic acid | 24280-93-1 | Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species. |
| CSN16132 | Mycophenolate Mofetil | 128794-94-5 | Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase III with IC50 of 39 nM and 27 nM, respectively. |
| CSN16915 | Merimepodib | 198821-22-6 | Merimepodiba is a noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase) with broad spectrum antiviral activities. |
| CSN27650 | LY 345899 | 10538-99-5 | LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM). |
| CSN16462 | Leflunomide | 75706-12-6 | Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 M, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis. |
| CSN24832 | LDH-A Inhibitor III | 1269802-68-7 | LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor. |
| CSN26126 | HQNO | 341-88-8 | HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2. |
| CSN28430 | GSK2837808A | 1445879-21-9 | GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. |
| CSN33152 | Galloflavin | 568-80-9 | Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor. |
| CSN27755 | G6PDi-1 | 2457232-14-1 | G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM. |
| CSN27625 | FX-11 | 213971-34-7 | FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM. |
| CSN27658 | DHODH-IN-11 | 1263303-95-2 | DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03. |
| CSN16289 | BVT 2733 | 376640-41-4 | BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11-HSD1). |
| CSN25383 | Brequinar Sodium | 96201-88-6 | Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis. |
| CSN25384 | Brequinar | 96187-53-0 | Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. |
| CSN25625 | BAY-2402234 | 2225819-06-5 | BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. |
| CSN25633 | LDHA-IN-4 | 1370290-34-8 | AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM. |
| CSN22691 | ASP-9521 | 1126084-37-4 | ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3 |
| CSN43933 | AG-636 | 1623416-31-8 | AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM. |
| CSN23342 | 3-Methylpyrazole | 1453-58-3 | 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil |
| CSN27552 | 2-Bromoacetamide | 683-57-8 | 2-Bromoacetamide can inactivate alcohol dehydrogenase. |
| CSN27116 | Inosinic acid (disodium)(hydrate)(1:2:X) | 352195-40-5 | |
| CSN24459 | 5-Ethynylpyrimidine-2,4(1H,3H)-dione | 59989-18-3 | |
| CSN27808 | Farudodstat | 1035688-66-4 | |
| CSN43225 | AZD8329 | 1048668-70-7 | |
| CSN43773 | (R)-BMS-816336 | 1009583-83-8 | |
| CSN70482 | ABT-384 | 868623-40-9 | |
| CSN70904 | AMG-221 | 1095565-81-3 | |
| CSN81054 | HSD-016 | 946396-92-5 |
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