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Dehydrogenase

Dehydrogenase

Cat. No. Product Name CAS No. Information
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN15519 Vibralactone D 1251748-32-9 Vibralactones D is a natural product isolated and purified from cultures of the basidiomycete Boreostereum vibrans, showing weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 mM (human HSD1), 295.2 mM (mouse HSD1), and 87.1 mM (human HSD2).
CSN13699 Teriflunomide   163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN11548 Teriflunomide(Random Configuration)   108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN23145 TC HSD 21 330203-01-5 TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].
CSN22561 Sodium 2,2-dichloroacetate   2156-56-1 Sodium 22-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase PDK with IC50s of 183 and 80 M for PDK2 and PDK4 respectively with tumor growth inhibition properties
CSN22557 RRx-001   925206-65-1 RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase G6PD
CSN22939 (R)-GNE-140 2003234-63-5 R-GNE-140 is a potent lactate dehydrogenase A LDHA inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively
CSN21792 Phenylglyoxal hydrate   1075-06-5 Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase ALDH binding the arginine residues in purified Hageman factor HF Factor XII and causes inhibition of its coagulant properties
CSN23240 Oxalacetic Acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN19396 Mycophenolic Acid   24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 Mycophenolate Mofetil   128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase III with IC50 of 39 nM and 27 nM, respectively.
CSN19079 ML390 2029049-79-2 ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia
CSN16462 Leflunomide   75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 M, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN22446 LDH-IN-1 1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
CSN24832 LDH-A Inhibitor III 1269802-68-7 LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor.
CSN11234 Isovaleramide   541-46-8 Isovaleramide a liver alcohol dehydrogenases inhibitor is an anticonvulsant molecule isolated from Valeriana pavonii
CSN19090 GNE-140 Racemate 1802977-61-2 GNE-140 racemate is a LDHA inhibitor
CSN16160 Glycyrrhizic Acid   1405-86-3 Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.
CSN16654 Gimeracil   103766-25-2 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase DPYD which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination
CSN19521 Fomepizole   7554-65-6 Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol
CSN20383 Crocetin 27876-94-4 Crocetin a saffron derivative is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer
CSN15809 CPI-613   95809-78-2 CPI-613 is an E1 pyruvate dehydrogenase PDH modulator that prevents cancer cells from metabolizing glucose for energy CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer
CSN20448 Carbenoxolone 5697-56-3 Carbenoxolone is a glucocorticoid that inhibits 11-hydroxysteroid dehydrogenase 11-HSD and blocks gap junction communication
CSN20425 Carbenoxolone Disodium 7421-40-1 Carbenoxolone disodium is a glucocorticoid that inhibits 11-hydroxysteroid dehydrogenase 11-HSD and blocks gap junction communication
CSN16289 BVT 2733 376640-41-4 BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11-HSD1).
CSN20563 BMS-823778 1140898-87-8 BMS-823778 is an orally available potent and selective inhibitor of 11--hydroxysteroid-dehydrogenase 1 11HSD-1 BMS-823778 is an antihyperglycaemic that may be a potential candidate for Type 2 diabetes treatment
CSN20222 BMS-816336 1009583-20-3 BMS-816336 a hydroxyl-substituted adamantyl acetamide has been identified as a potent inhibitor against human 11-hydroxysteroid dehydrogenase type 111-HSD1 enzyme IC50 30 nM with 10000 fold selectivity over human 11-hydroxysteroid dehydrogenase type 211-HSD2
CSN19747 BI-135585 1114561-85-1 BI-135585 is a potent and selective 11-HSD1 inhibitor for treating Type 2 diabetes
CSN20651 AZD4017 1024033-43-9 AZD4017 is a potent selective and orally bioavailable11-HSD1 inhibitor 11-hydroxysteroid dehydrogenase type 1 inhibitor Inhibition of 11-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome
CSN25633 AZ 33 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP 9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3
CSN22599 Ammonium Glycyrrhizinate(x:1) 1407-03-0 Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses.
CSN22906 6PGD-IN-S3 5539-66-2 6PGD-IN-S3 is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).
CSN23342 3-Methylpyrazole   1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil
CSN25384 Brequinar 96187-53-0
CSN25383 Brequinar sodium 96201-88-6
CSN25455 Ethyl potassium malonate 6148-64-7
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