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Dehydrogenase

Dehydrogenase

Cat. No. Product Name CAS No. Information
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN13699 Teriflunomide   163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN11548 (E/Z)-Teriflunomide   108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN23145 TC HSD 21 330203-01-5 TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].
CSN26191 R162 64302-87-0 R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth.
CSN22939 (R)-GNE-140 2003234-63-5 R-GNE-140 is a potent lactate dehydrogenase A LDHA inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively
CSN24124 Pyrazinecarboxylic acid 98-97-5 Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.
CSN23240 Oxaloacetic acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN19396 Mycophenolic acid   24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 Mycophenolate Mofetil   128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase III with IC50 of 39 nM and 27 nM, respectively.
CSN16915 Merimepodib 198821-22-6 Merimepodiba is a noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase) with broad spectrum antiviral activities.
CSN27650 LY 345899 10538-99-5 LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM).
CSN16462 Leflunomide   75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 M, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN24832 LDH-A Inhibitor III 1269802-68-7 LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor.
CSN26126 HQNO 341-88-8 HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
CSN28430 GSK2837808A   1445879-21-9 GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells.
CSN33152 Galloflavin 568-80-9 Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor.
CSN27755 G6PDi-1 2457232-14-1 G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM.
CSN27625 FX-11 213971-34-7 FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM.
CSN27658 DHODH-IN-11   1263303-95-2 DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.
CSN16289 BVT 2733 376640-41-4 BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11-HSD1).
CSN25383 Brequinar Sodium 96201-88-6 Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis.
CSN25384 Brequinar 96187-53-0 Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses.
CSN25625 BAY-2402234 2225819-06-5 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
CSN25633 LDHA-IN-4 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP-9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3
CSN43933 AG-636 1623416-31-8 AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM.
CSN23342 3-Methylpyrazole   1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil
CSN27552 2-Bromoacetamide 683-57-8 2-Bromoacetamide can inactivate alcohol dehydrogenase.
CSC24124 Pyrazinecarboxylic acid 98-97-5
CSC25383 Brequinar Sodium 96201-88-6
CSN27116 Inosinic acid (disodium)(hydrate)(1:2:X) 352195-40-5
CSN24459 5-Ethynylpyrimidine-2,4(1H,3H)-dione 59989-18-3
CSN27808 Farudodstat 1035688-66-4
CSN43225 AZD8329 1048668-70-7
CSN43773 (R)-BMS-816336 1009583-83-8
CSN70482 ABT-384 868623-40-9
CSN70904 AMG-221 1095565-81-3
CSN81054 HSD-016 946396-92-5
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