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CXCR

CXCR

Cat. No. Product Name CAS No. Information
CSN17345 ZK756326 874911-96-3 ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
CSN15996 WZ811 55778-02-4 WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.
CSN23188 VUF 11222 1414376-84-3 VUF-11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2).
CSN23717 USL-311 1373268-67-7 USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].
CSN18633 UNBS5162   956590-23-1 UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 179 M for 9 cancer cell lines
CSN23324 Tannic Acid 5424-20-4 Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN17557 SRT3190 1204707-73-2 SRT3190 is CXCR2 ligand.
CSN17556 SRT3109 1204707-71-0 SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
CSN19351 SCH-563705 473728-58-4 SCH-563705 is a potent dual CXCR2 (IC50 1.3 nM)CXCR1 (IC50 7.3 nM) antagonist.
CSN12829 SCH-527123 473727-83-2 SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CSN13174 SCH-546738 906805-42-3 SCH 546738 is a potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
CSN17197 SB-225002   182498-32-4 SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing 150-fold selectivity over CXCR1 and four other 7-TMRs.
CSN23103 SB 332235 276702-15-9 SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner.
CSN23101 SB 265610 211096-49-0 SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
CSN18171 Reparixin L-lysine 266359-93-7 Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models.
CSN15950 Reparixin 266359-83-5 Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.
CSN12664 Plerixafor   110078-46-1 Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN16151 Plerixafor 8HCl   155148-31-5 Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN23012 NVP CXCR2 20 1029521-30-9 NVP CXCR2 20 is a potent and selective CXCR2 antagonist with IC50 of 40 nM.
CSN18477 NBI-74330 855527-92-3 NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of (125)ICXCL10 and (125)ICXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.
CSN21269 MSX-130 4051-59-6 MSX-130 is CXCR4 Antagonist
CSN18542 MSX-122 897657-95-3 MSX-122 is a small molecule and partial CXCR4 antagonist with potent inhibition of CXCR4CXCL12 actions IC50 10 nM
CSN21198 LY2510924 1088715-84-7 LY2510924 is an inhibitor of CXC chemokine receptor 4 CXCR4 with potential antineoplastic activity Upon subcutaneous administration LY2510924 binds to the chemokine receptor CXCR4 thereby preventing CXCR4 binding to its ligand stromal derived factor-1 SDF-1 and subsequent receptor activation
CSN24505 JMS-17-2   1380392-05-1 JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.
CSN22862 IT1t 2HCl 1092776-63-0 IT1t 2HCl is a potent CXCR4 antagonist with IC50 of 1.1 nM.
CSN22815 FC 131 606968-52-9 FC 131 is a CXCR4 antagonist with IC50 of 126 nM.
CSN18630 Danirixin 954126-98-8 Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding 12.5 nM), selective, and reversible CXCR2 antagonist.
CSN23143 TC 14012 368874-34-4 CXCR4 antagonist; ACKR3 (CXCR7) agonist
CSN22780 CTCE 9908 1030384-98-5 CTCE 9908 is a CXCR4 antagonist with antitumor activity.
CSN15665 Baohuoside I 113558-15-9 Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.
CSN21987 AZD8797 911715-90-7 AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor which antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
CSN22921 AZD5069 878385-84-3 AZD 5069 is a selective and reversible antagonist of CXCR2 that can inhibit CXCL8 binding to CXCR2 with pIC50 of 91
CSN22697 AZ 10397767 333742-63-5 AZ 10397767 is a potent CXCR2 antagonist with IC50 of 1 nM.
CSN19244 ATI-2341 1337878-62-2 ATI-2341 pepducin targeting the C-X-C chemokine receptor type 4 CXCR4 is an allosteric agonist activating the inhibitory heterotrimeric G protein Gi to promote inhibition of cAMP production and induce calcium mobilization
CSN18287 AMG-487 473719-41-4 AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.
CSN13161 AMD-070 558447-26-0 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN24435 Mavorixafor 3HCl 2309699-17-8 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN13824 AMD-070 HCl 880549-30-4 AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN18051 AMD 3465 185991-24-6 AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1-ligand binding (Ki 41.7 nM).
CSN16529 AMD 3465 Hexahydrobromide 185991-07-5 AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1-ligand binding (Ki 41.7 nM).
CSN22622 (±)-NBI 74330 473722-68-8 (±)-NBI 74330 is a potent and selective CXCR3 antagonist that potently inhibits 125I-CXCL10 binding to CXCR3 with pKi of 8.13.
CSN22618 (±)-AMG 487 947536-03-0 (±)-AMG 487 is an antagonist of CXCR3 that inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 with IC50 of 8.0 and 8.2 nM respectively.
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