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CXCR

CXCR

Cat. No. Product Name CAS No. Information
CSN15996 WZ811 55778-02-4 WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.
CSN23717 USL311 1373268-67-7 USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].
CSN18633 UNBS5162 956590-23-1 UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 179 M for 9 cancer cell lines
CSN27389 SX-682 1648843-04-2 SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
CSN17557 SRT3190 1204707-73-2 SRT3190 is CXCR2 ligand.
CSN17556 SRT3109 1204707-71-0 SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
CSN19351 SCH 563705 473728-58-4 SCH-563705 is a potent dual CXCR2 (IC50 1.3 nM)CXCR1 (IC50 7.3 nM) antagonist.
CSN12829 Navarixin 473727-83-2 SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CSN13174 SCH 546738 906805-42-3 SCH 546738 is a potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
CSN17197 SB225002   182498-32-4 SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing 150-fold selectivity over CXCR1 and four other 7-TMRs.
CSN23103 SB-332235 276702-15-9 SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner.
CSN23101 SB-265610 211096-49-0 SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
CSN18171 Reparixin L-lysine salt 266359-93-7 Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models.
CSN15950 Reparixin 266359-83-5 Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.
CSN12664 Plerixafor   110078-46-1 Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN16151 Plerixafor octahydrochloride   155148-31-5 Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN23012 NVP CXCR2 20 1029521-30-9 NVP CXCR2 20 is a potent and selective CXCR2 antagonist with IC50 of 40 nM.
CSN18477 NBI-74330 855527-92-3 NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of (125)ICXCL10 and (125)ICXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.
CSN21269 MSX-130 4051-59-6 MSX-130 is CXCR4 Antagonist
CSN32932 Ladarixin sodium 865625-56-5 Ladarixin Sodium is a CXCR antagonist potentially for the treatment of type I diabetes.
CSN32931 Ladarixin 849776-05-2 Ladarixin is a dual, non-competitive, allosteric inhibitor of CXCR1 and CXCR2 interleukin-8 (IL-8A and IL-8B, respectively).
CSN24505 JMS-17-2   1380392-05-1 JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.
CSN22862 IT1t dihydrochloride 1092776-63-0 IT1t 2HCl is a potent CXCR4 antagonist with IC50 of 1.1 nM.
CSN18630 Danirixin 954126-98-8 Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding 12.5 nM), selective, and reversible CXCR2 antagonist.
CSN26625 CXCR7 modulator 2 2227426-37-9 CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.
CSN32401 Burixafor 1191448-17-5 Burixafor is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities.
CSN15665 Baohuoside I 113558-15-9 Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.
CSN21987 AZD8797 911715-90-7 AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor which antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
CSN22921 AZD-5069 878385-84-3 AZD 5069 is a selective and reversible antagonist of CXCR2 that can inhibit CXCL8 binding to CXCR2 with pIC50 of 91
CSN18287 AMG 487 473719-41-4 AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.
CSN13161 Mavorixafor 558447-26-0 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN24435 Mavorixafor trihydrochloride 2309699-17-8 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN13824 (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride 880549-30-4 AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN18051 AMD 3465 185991-24-6 AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1-ligand binding (Ki 41.7 nM).
CSN16529 AMD 3465 hexahydrobromide 185991-07-5 AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1-ligand binding (Ki 41.7 nM).
CSN22618 (±)-AMG 487 947536-03-0 (±)-AMG 487 is an antagonist of CXCR3 that inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 with IC50 of 8.0 and 8.2 nM respectively.
CSN73217 (E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide 1378524-41-4
CSN83400 CCX-777 1226686-36-7
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