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CRM1
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17781 | Verdinexor (KPT-335) | 1392136-43-4 | Verdinexor is an orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and also reduce influenza virus replication in vitro and in vivo. |
| CSN20669 | Leptomycin B | 87081-35-4 | Leptomycin B is an inhibitor of the nuclear export of proteins which acts by binding directly to and inhibiting CRM1/exportin-1. Leptomycin B inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53, showing antiviral, antibiotic, antifunal and antitumor in vitro and in vivo. |
| CSN19083 | Eltanexor Z-isomer | 1642300-78-4 | KPT-8602 Z-isomer is an isomer of KPT-8602 which is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity |
| CSN19082 | Eltanexor (KPT-8602) | 1642300-52-4 | KPT-8602 is a second-generation and oral acitve exportin-1 XPO1CRM1 inhibitor with IC50 of 20211nM in 10 AML cell lines. |
| CSN16156 | Selinexor (KPT-330) | 1393477-72-9 | KPT-330 analog of KPT-185 is an orally bioavailable selective CRM1 inhibitor |
| CSN17829 | KPT-276 | 1421919-75-6 | KPT-276 analog of KPT-185 is a CRM1 blocker and acts as an orally bioavailable selective inhibitor of nuclear export SINE by irreversibly binding to CRM1 |
| CSN17700 | KPT-185 | 1333151-73-7 | KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 25 nM |
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