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COX
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17004 | alpha-Cyperone | 473-08-5 | α-Cyperone, a natural product isolated and purified from the hizomes of Cyperus rotundus L., is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation. |
| CSN21861 | Timegadine | 71079-19-1 | Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase. |
| CSN22039 | Tilmacoxib | 180200-68-4 | Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay. |
| CSN26375 | Tenidap | 120210-48-2 | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap shows anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor. |
| CSN24972 | Syringaldehyde | 134-96-3 | Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. |
| CSN12019 | Suprofen | 40828-46-4 | Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| CSN13982 | Sphondin | 483-66-9 | Sphondin, a natural product isolated and purified from the fruits of Heracleum sibiricum L., possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. |
| CSN25628 | PTUPB | 1287761-01-6 | PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity. |
| CSN16384 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| CSN17306 | Phenylbutazone | 50-33-9 | Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. |
| CSN27387 | Metyrosine | 672-87-7 | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control. |
| CSN24828 | Meclofenamic acid | 644-62-2 | Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker. |
| CSN25653 | Pamicogrel | 101001-34-7 | KBT3022 is a COX inhibitor. |
| CSN10263 | Indoprofen | 31842-01-0 | Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. |
| CSN25380 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| CSN25380 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| CSN13579 | Glafenine | 3820-67-5 | Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins. |
| CSN25325 | FPL 62064 | 103141-09-9 | FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity. |
| CSN21647 | Flosulide | 80937-31-1 | Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases. |
| CSN16015 | Fenoprofen Calcium hydrate | 71720-56-4 | Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. |
| CSN10965 | Etofenamate | 30544-47-9 | Etofenamate is a non-steroidal anti-inflammatory drug used for the treatment joint and muscular pain. |
| CSN29479 | (S)-Flurbiprofen | 51543-39-6 | Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation. |
| CSN32688 | (+)-Columbianetin | 3804-70-4 | COX-2 Expression Inhibitors, Interleukin-1beta (IL1B; IL-1beta) Production Inhibitors, Interleukin-6 (IL-6) Production Inhibitors, Interleukin-8 (CXCL8; IL-8) Production Inhibitors, Signal Transduction Modulators, TNF-alpha Production Inhibitors |
| CSN26550 | COX/5-LO-IN-1 | 154355-75-6 | Atreleuton racemic is a racemic mixture of Atreleuton, is a 5-lipozygenase inhibitor used to treat asthma. Atreleuton, also known as ABT-761, VIA-2291, A-85761; Abbott-85761, is a reversible 5-lipoxygenase inhibitor. Atreleuton exhibits potent and selective inhibition of leukotriene formation. |
| CSN24869 | (E)-Ethyl p-methoxycinnamate | 24393-56-4 | A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively); reduces IL-1 and TNF-a production in vivo; inhibits granuloma tissue formation in a dose-dependent manner in rats; inhibits blood vessel gr |
| CSN19939 | [8]-Shogaol | 36700-45-5 | 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells. |
| CSN27388 | 3,3'-Diiodo-L-thyronine | 4604-41-5 | 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. |
| CSN27376 | 2,6-Dichlorodiphenylamine | 15307-93-4 | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. |
| CSN14023 | (-)-Epiafzelechin | 24808-04-6 | (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. |
| CSN41962 | S-(+)-Marmesin | 13849-08-6 | |
| CSN34081 | S-2474 | 158089-95-3 | |
| CSN34195 | RWJ 63556 | 190967-35-2 | |
| CSN36079 | Phenethyl ferulate | 71835-85-3 | |
| CSN43929 | CAY10698 | 684236-01-9 | |
| CSN50045 | Tepoxalin | 103475-41-8 | |
| CSN84768 | COX-2-IN-22 | 2447589-08-2 | |
| CSN85018 | COX-2/5-LOX-IN-3 | 2481484-51-7 | |
| CSN51531 | (Z)-5-Amino-4-methyl-3-(4-(methylsulfonyl)benzylidene)-3,4-dihydro-2H-pyrrol-2-one methanesulfonate | 1051931-39-5 |
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