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COX

COX

Cat. No. Product Name CAS No. Information
CSN17004 alpha-Cyperone 473-08-5 α-Cyperone, a natural product isolated and purified from the hizomes of Cyperus rotundus L., is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation.
CSN21861 Timegadine 71079-19-1 Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase.
CSN22039 Tilmacoxib 180200-68-4 Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay.
CSN26375 Tenidap 120210-48-2 Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap shows anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor.
CSN24972 Syringaldehyde 134-96-3 Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.
CSN12019 Suprofen   40828-46-4 Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN13982 Sphondin 483-66-9 Sphondin, a natural product isolated and purified from the fruits of Heracleum sibiricum L., possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
CSN25628 PTUPB 1287761-01-6 PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity.
CSN16384 Pranoprofen   52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN17306 Phenylbutazone   50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN25653 Pamicogrel 101001-34-7 KBT3022 is a COX inhibitor.
CSN10263 Indoprofen 31842-01-0 Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN13579 Glafenine 3820-67-5 Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN21647 Flosulide 80937-31-1 Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases.
CSN16015 Fenoprofen Calcium hydrate   71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN10965 Etofenamate 30544-47-9 Etofenamate is a non-steroidal anti-inflammatory drug used for the treatment joint and muscular pain.
CSN29479 (S)-Flurbiprofen 51543-39-6 Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation.
CSN32688 (+)-Columbianetin 3804-70-4 COX-2 Expression Inhibitors, Interleukin-1beta (IL1B; IL-1beta) Production Inhibitors, Interleukin-6 (IL-6) Production Inhibitors, Interleukin-8 (CXCL8; IL-8) Production Inhibitors, Signal Transduction Modulators, TNF-alpha Production Inhibitors
CSN26550 COX/5-LO-IN-1 154355-75-6 Atreleuton racemic is a racemic mixture of Atreleuton, is a 5-lipozygenase inhibitor used to treat asthma. Atreleuton, also known as ABT-761, VIA-2291, A-85761; Abbott-85761, is a reversible 5-lipoxygenase inhibitor. Atreleuton exhibits potent and selective inhibition of leukotriene formation.
CSN24869 (E)-Ethyl p-methoxycinnamate 24393-56-4 A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively); reduces IL-1 and TNF-a production in vivo; inhibits granuloma tissue formation in a dose-dependent manner in rats; inhibits blood vessel gr
CSN19939 [8]-Shogaol 36700-45-5 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
CSN41962 S-(+)-Marmesin 13849-08-6
CSN34081 S-2474 158089-95-3
CSN34195 RWJ 63556 190967-35-2
CSN36079 Phenethyl ferulate 71835-85-3
CSN43929 CAY10698 684236-01-9
CSN50045 Tepoxalin 103475-41-8
CSN84768 COX-2-IN-22 2447589-08-2
CSN85018 COX-2/5-LOX-IN-3 2481484-51-7
CSN51531 (Z)-5-Amino-4-methyl-3-(4-(methylsulfonyl)benzylidene)-3,4-dihydro-2H-pyrrol-2-one methanesulfonate 1051931-39-5
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