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COX

COX

Cat. No. Product Name CAS No. Information
CSN12125 trans-Cinnamaldehyde   14371-10-9 Trans-Cinnamaldehyde is a natural product isolated from cinnamon essential oil, role as a hypoglycemic agent, a phenylalanine ammonia-lyase inhibitor, a vasodilator agent, an antifungal agent, a flavouring agent, a plant metabolite and a sensitiser.
CSN12019 Suprofen   40828-46-4 Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN11971 Salsalate   552-94-3 Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug.
CSN16640 Rutaecarpine   84-26-4 Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
CSN16384 Pranoprofen   52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN17306 Phenylbutazone   50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN21767 NPPB   107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 M and inhibitor of cyclooxygenase IC50 8 M
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN20674 Mavacoxib 170569-88-7 Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN19903 Isoorientin 4261-42-1 Isoorientin is a natural product isolated and purified from the herbs of Polygonum orientale Linn. with antioxidant activity.
CSN21951 Indobufen   63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN16502 Guaiacol   90-05-1 Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN16015 Fenoprofen Calcium Dihydrate   71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN16343 Asaronaldehyde   4460-86-0 Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott.
CSN19498 4-Aminoantipyrine   83-07-8 4-Aminoantipyrine is used as a reagent for glucose determination in the presence of peroxidase and phenol, it is a metabolite of aminopyrine with analgesic, anti-inflammatory and antipyretic properties.
CSN18711 3,4-Dimethoxybenzoic Acid   93-07-2 3,4-Dimethoxybenzoic acid is a natural product isolated and purified from the fruits of Phyllanthus emblica L..
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN17031 (S)-(+)-Ibuprofen   51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN12679 (-)-Epicatechin   490-46-0 (-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 3.2 M) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. ()-Epicatechin is a 2R,3R stereoisomer of catechin.
CSN16512 (+)-Catechin   154-23-4 (+)-Catechin, a plant secondary metabolite, is an antioxidant flavonoid found in the bark of taxus yunnanensis with anti-atherosclerosis.
CSN16856 (±)-Sulfinpyrazone   57-96-5 ()-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
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