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COX

COX

Cat. No. Product Name CAS No. Information
CSN12218 Xanthohumol   6754-58-1 Xanthohumol, a prenylated chalcone from hop, is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2 and shows chemopreventive effects.
CSN12125 trans-Cinnamaldehyde   14371-10-9 Trans-Cinnamaldehyde is a natural product isolated from cinnamon essential oil, role as a hypoglycemic agent, a phenylalanine ammonia-lyase inhibitor, a vasodilator agent, an antifungal agent, a flavouring agent, a plant metabolite and a sensitiser.
CSN21861 Timegadine 71079-19-1 Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase.
CSN22039 JTE522 180200-68-4 Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay.
CSN24972 Syringaldehyde 134-96-3 Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.
CSN12019 Suprofen   40828-46-4 Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN11971 Salsalate   552-94-3 Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug.
CSN13702 Salicin   138-52-3 Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol -glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects.
CSN16640 Rutaecarpine   84-26-4 Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
CSN16384 Pranoprofen   52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN17306 Phenylbutazone   50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN21767 NPPB   107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 M and inhibitor of cyclooxygenase IC50 8 M
CSN13648 N-trans-Feruloyltyramine 66648-43-9 N-trans-Feruloyltyramine, a natural product isolated and purified from the herbs of Cannabis sativa L., has antioxidative activity against A(1-42)-induced neuronal death. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor.
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN19903 Isoorientin 4261-42-1 Isoorientin is a natural product isolated and purified from the herbs of Polygonum orientale Linn. with antioxidant activity.
CSN21951 Indobufen   63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN16502 Guaiacol   90-05-1 Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN21647 Flosulide 80937-31-1 Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases.
CSN16015 Fenoprofen Calcium Dihydrate   71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN20998 DehydropachyMic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
CSN16343 Asaronaldehyde   4460-86-0 Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott.
CSN19498 4-Aminoantipyrine   83-07-8 4-Aminoantipyrine is used as a reagent for glucose determination in the presence of peroxidase and phenol, it is a metabolite of aminopyrine with analgesic, anti-inflammatory and antipyretic properties.
CSN10169 4',7-Dihydroxyflavone 2196-14-7 4,7-Dihydroxyflavone is a natural product isolated and purified from the heartwood of Pterocarpus marsupium, with inhibitory activities against COX-2.
CSN18711 3,4-Dimethoxybenzoic Acid   93-07-2 3,4-Dimethoxybenzoic acid is a natural product isolated and purified from the fruits of Phyllanthus emblica L..
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN17031 (S)-(+)-Ibuprofen   51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN12679 (-)-Epicatechin   490-46-0 (-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 3.2 M) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. ()-Epicatechin is a 2R,3R stereoisomer of catechin.
CSN11587 (-)-Epicatechin Gallate 1257-08-5 (-)-Epicatechin gallate, a polyphenol, is a apoptosis inducer of tumor cells that found in green tea.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
CSN16512 (+)-Catechin   154-23-4 (+)-Catechin, a plant secondary metabolite, is an antioxidant flavonoid found in the bark of taxus yunnanensis with anti-atherosclerosis.
CSN16856 (±)-Sulfinpyrazone   57-96-5 ()-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
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