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COX

COX

Cat. No. Product Name CAS No. Information
CSN12218 Xanthohumol   6754-58-1 Xanthohumol, a prenylated chalcone from hop, is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2 and shows chemopreventive effects.
CSN12344 Valdecoxib   181695-72-7 Valdecoxib is a potent COX inhbitor that selectively inhibitors COX-2 with IC50 of 5 nM.
CSN12125 trans-Cinnamaldehyde   14371-10-9 Trans-Cinnamaldehyde is a natural product isolated from cinnamon essential oil, role as a hypoglycemic agent, a phenylalanine ammonia-lyase inhibitor, a vasodilator agent, an antifungal agent, a flavouring agent, a plant metabolite and a sensitiser.
CSN21861 Timegadine 71079-19-1 Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase.
CSN22039 JTE522 180200-68-4 Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay.
CSN11971 Salsalate   552-94-3 Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug.
CSN17306 Phenylbutazone   50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN12368 Parecoxib Sodium   198470-85-8 Parecoxib Sodium, a water-soluble and injectable prodrug of valdecoxib, is a COX2 inhibitor used for the short-term treatment of postoperative pain in adults.
CSN13805 Parecoxib   198470-84-7 Parecoxib is a potent and selective COX2 inhibitor.
CSN21767 NPPB   107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 M and inhibitor of cyclooxygenase IC50 8 M
CSN12605 Naproxen   22204-53-1 Naproxen is a COX inhibitor for COX12 with IC50 of 8.7 and 5.2 M, respectively.
CSN13648 N-trans-Feruloyltyramine 66648-43-9 N-trans-Feruloyltyramine, a natural product isolated and purified from the herbs of Cannabis sativa L., has antioxidative activity against A(1-42)-induced neuronal death. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor.
CSN12893 Meloxicam   71125-38-7 Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 11.8 M) over COX1 (IC50 143 M) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity.
CSN15928 Licofelone 156897-06-2 Licofelone is a dual COXLOX inhibitor being considered as a treatment for osteoarthritis.
CSN11253 Ketorolac Tromethamine 74103-07-4 Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 M and 3.50 M, respectively.
CSN19903 Isoorientin 4261-42-1 Isoorientin is a natural product isolated and purified from the herbs of Polygonum orientale Linn. with antioxidant activity.
CSN11203 Indomethacin Farnesil 85801-02-1 Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin.
CSN16502 Guaiacol   90-05-1 Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes.
CSN11122 Guacetisal   55482-89-8 Guacetisal is a drug that has been used to treat inflammatory respiratory diseases.
CSN11030 Flunixin Meglumine   42461-84-7 Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
CSN21647 Flosulide 80937-31-1 Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases.
CSN12948 Firocoxib   189954-96-9 Firocoxib is a potent and selective COX2 inhibitor with IC50 of 0.13 M.
CSN11003 Fenoprofen Calcium   34597-40-5 Fenoprofen Calcium is COX-12 inhibitor used as an NSAID. It can also inhibit fatty acid oxidation and acts as a peroxisome proliferator.
CSN16015 Fenoprofen Calcium Dihydrate   71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN10999 Fenbufen   36330-85-5 Fenbufen is a phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.
CSN10969 Etoricoxib   202409-33-4 Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 0.1 M and 116 8 M for COX1.
CSN10773 Deracoxib   169590-41-4 Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
CSN19134 Chebulagic Acid 23094-71-5 Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.
CSN10518 Butibufen 55837-18-8 Butibufen, is a cyclooxygenase inhibitor used to treat inflammatory and rheumatic disorders.
CSN10503 Bufexamac   2438-72-4 Bufexamac is a COX inhibitor used as an anti-inflammatory agent.
CSN10398 Benorylate   5003-48-5 Benorylate HCl is an ester-linked codrug of aspirin with paracetamol, used as an anti-inflammatory and antipyretic medication.
CSN15857 ATB-346 1226895-20-0 ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
CSN10302 Ampiroxicam 99464-64-9 Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
CSN10286 Aminoprofen 82821-47-4 Aminoprofen is NSAID (non-steroidal anti-inflammatory drug) and non selective COX inhibitor. Aminoprofen is used to relieve mild to moderate pain.
CSN10202 Acemetacin   53164-05-9 Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
CSN10201 Aceclofenac   89796-99-6 Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of diclofenac.
CSN19939 8-Shogaol 36700-45-5 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.
CSN19498 4-Aminoantipyrine   83-07-8 4-Aminoantipyrine is used as a reagent for glucose determination in the presence of peroxidase and phenol, it is a metabolite of aminopyrine with analgesic, anti-inflammatory and antipyretic properties.
CSN18711 3,4-Dimethoxybenzoic Acid     93-07-2 3,4-Dimethoxybenzoic acid is a natural product isolated and purified from the fruits of Phyllanthus emblica L..
CSN18224 1-O-Acetylbritannilactone 33627-41-7 1-O-Acetylbritannilactone is a sesquiterpene isolated from the medicinal plant Inula britannica with anticancer and anti-inflammation acitvity.
CSN12679 (-)-Epicatechin   490-46-0 (-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 3.2 M) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. ()-Epicatechin is a 2R,3R stereoisomer of catechin.
CSN11587 (-)-Epicatechin Gallate 1257-08-5 (-)-Epicatechin gallate, a polyphenol, is a apoptosis inducer of tumor cells that found in green tea.
CSN16833 (-)-Catechin Gallate 130405-40-2 (-)-Catechin gallate is a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., can enhance Fe(2)-induced lipid peroxidation.
CSN16512 (+)-Catechin   154-23-4 (+)-Catechin, a plant secondary metabolite, is an antioxidant flavonoid found in the bark of taxus yunnanensis with anti-atherosclerosis.
CSN16846 (+)-Catechin Hydrate(1:x)   225937-10-0 ()-Catechin, a natural product isolated and purified from the herbs of Camellia sinensis, has antioxidant activity and is effective in reducing oxidative stress.
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