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COX

COX

Cat. No. Product Name CAS No. Information
CSN12218 Xanthohumol   6754-58-1 Xanthohumol, a prenylated chalcone from hop, is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2 and shows chemopreventive effects.
CSN12125 trans-Cinnamaldehyde   14371-10-9 Trans-Cinnamaldehyde is a natural product isolated from cinnamon essential oil, role as a hypoglycemic agent, a phenylalanine ammonia-lyase inhibitor, a vasodilator agent, an antifungal agent, a flavouring agent, a plant metabolite and a sensitiser.
CSN21861 Timegadine 71079-19-1 Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase.
CSN22039 JTE522 180200-68-4 Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay.
CSN22101 Tetrahydropalmatine HCl 6024-85-7 Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner.
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN11971 Salsalate   552-94-3 Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug.
CSN25628 PTUPB 1287761-01-6 PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity.
CSN11226 Propyphenazone 479-92-5 Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
CSN17306 Phenylbutazone   50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN13885 Phenacetin   62-44-2 Phenacetin is a non-opioid analgesic used in treatment of pain-relieving and fever-reducing.
CSN13805 Parecoxib   198470-84-7 Parecoxib is a potent and selective COX2 inhibitor.
CSN21767 NPPB   107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 M and inhibitor of cyclooxygenase IC50 8 M
CSN13648 N-trans-Feruloyltyramine 66648-43-9 N-trans-Feruloyltyramine, a natural product isolated and purified from the herbs of Cannabis sativa L., has antioxidative activity against A(1-42)-induced neuronal death. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN11337 Loxoprofen   68767-14-6 Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and propionic acid derivative.
CSN11332 Lornoxicam   70374-39-9 Lornoxicam is a COX inhibitor with IC50 of 5 nM and 8 nM for COX1 and 2 respectively. Its a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of various types of pain.
CSN11252 Ketoprofen   22071-15-4 Ketoprofen is a dual COX12 inhibitor with IC50 of 0.5 M and 2.33 M for human recombinant COX-1 and COX-2, respectively, and used as a nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis-related inflammatory pains.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN19903 Isoorientin 4261-42-1 Isoorientin is a natural product isolated and purified from the herbs of Polygonum orientale Linn. with antioxidant activity.
CSN16502 Guaiacol   90-05-1 Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes.
CSN11122 Guacetisal   55482-89-8 Guacetisal is a drug that has been used to treat inflammatory respiratory diseases.
CSN11030 Flunixin Meglumine   42461-84-7 Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN21647 Flosulide 80937-31-1 Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases.
CSN11003 Fenoprofen Calcium   34597-40-5 Fenoprofen Calcium is COX-12 inhibitor used as an NSAID. It can also inhibit fatty acid oxidation and acts as a peroxisome proliferator.
CSN16015 Fenoprofen Calcium Dihydrate   71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN10969 Etoricoxib   202409-33-4 Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 0.1 M and 116 8 M for COX1.
CSN10773 Deracoxib   169590-41-4 Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
CSN19134 Chebulagic Acid 23094-71-5 Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.
CSN10398 Benorylate   5003-48-5 Benorylate HCl is an ester-linked codrug of aspirin with paracetamol, used as an anti-inflammatory and antipyretic medication.
CSN15857 ATB-346 1226895-20-0 ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
CSN10302 Ampiroxicam 99464-64-9 Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
CSN14397 alpha-Viniferin 62218-13-7 alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
CSN19939 8-Shogaol 36700-45-5 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.
CSN19498 4-Aminoantipyrine   83-07-8 4-Aminoantipyrine is used as a reagent for glucose determination in the presence of peroxidase and phenol, it is a metabolite of aminopyrine with analgesic, anti-inflammatory and antipyretic properties.
CSN18711 3,4-Dimethoxybenzoic Acid   93-07-2 3,4-Dimethoxybenzoic acid is a natural product isolated and purified from the fruits of Phyllanthus emblica L..
CSN18224 1-O-Acetylbritannilactone 33627-41-7 1-O-Acetylbritannilactone is a sesquiterpene isolated from the medicinal plant Inula britannica with anticancer and anti-inflammation acitvity.
CSN12679 (-)-Epicatechin   490-46-0 (-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 3.2 M) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. ()-Epicatechin is a 2R,3R stereoisomer of catechin.
CSN11587 (-)-Epicatechin Gallate 1257-08-5 (-)-Epicatechin gallate, a polyphenol, is a apoptosis inducer of tumor cells that found in green tea.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
CSN16833 (-)-Catechin Gallate 130405-40-2 (-)-Catechin gallate is a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., can enhance Fe(2)-induced lipid peroxidation.
CSN16512 (+)-Catechin   154-23-4 (+)-Catechin, a plant secondary metabolite, is an antioxidant flavonoid found in the bark of taxus yunnanensis with anti-atherosclerosis.
CSN16846 (+)-Catechin Hydrate(1:x) 225937-10-0 ()-Catechin, a natural product isolated and purified from the herbs of Camellia sinensis, has antioxidant activity and is effective in reducing oxidative stress.
CSN25380 Ibuprofen piconol 64622-45-3
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