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Coumarins

Coumarins

Cat. No. Product Name CAS No. Information
CSN12220 Xanthotoxol 2009-24-7 Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia.
CSN14013 Wedelolactone 524-12-9 Wedelolactone, a natural compound derived from Chinese herbal medicine Eclipta prostrate L, is an anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase II.
CSN13084 Umbelliferone   93-35-6 Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.
CSN14215 Tomentin 28449-62-9 Tomentin, a natural product isolated and purified from the barks of Jatropha curcas, can inhibit papain-like protease and has anti-inflammatory activity.
CSN13943 Suberosin 581-31-7 Suberosin, a natural product isolated and purified from the roots of Angelica pubescens, inhibits PHA-induced PBMC proliferation, at least in part, through reduction of Ca2i, ERK, NF-AT, and NF-kappaB activation, and early gene expression in PBMC including cyclins and cytokines, and arrest of cell cycle progression in the cells.
CSN15640 Scopolin 531-44-2 Scopolin, a natural product isolated and purified from the herb of Scopolia japonica, can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis,and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
CSN13328 Scopoletin Acetate 56795-51-8 Scopoletin acetate is a natural product isolated and purified from the herbs of Atropa belladonna L..
CSN16631 Scoparone   120-08-1 Scoparone, a natural product isolated and purified from the herbs of Artemisia scoparia, with antifungal, antianginal, antioxidant, immunosuppression and vasorelaxation effects, protects against carbon tetrachloride-induced liver injury, is a very efficient inhibitor of ultraviolet radiation -induced lipid peroxidation and damage, and a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.
CSN16448 Psoralen   66-97-7 Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity.
CSN19790 Oxypeucedanin 737-52-0 Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.
CSN13525 Notopterol   88206-46-6 Notopterol induces apoptosis and inhibits cell cycle-specific, its a natural product isolated and purified from the roots of Notopterygium incisum.
CSN19936 Nodakenin 495-31-8 Nodakenin is a natural product isolated and purified from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan. with anti-aggregatory, antibacterial, anti-allergic, anti- inflammator, and memory-enhancing effects.
CSN14208 Murrangatin 37126-91-3 Murrangatin, a natural anti-tumor-promoting agent isolated and purified from the herbs of Murraya exotica L., exhibits cytotoxicity against cholangiocarcinoma cell line and significantly inhibits EBV-EA activation, and preserves the high viability of Raji cells.
CSN14096 mMelin 15085-71-9 mMelin is a natural product isolated and purified from the herbs of Micromelum integerrimum with antitumor activity and cytotoxicity against cholangiocarcinoma cell line, KKU-100.
CSN14210 Minumicrolin 88546-96-7 Minumicrolin, a natural potential anti-tumor agent isolated and purified from the herbs of Murraya exotica L., shows mild butyrylcholinesterase inhibition activity and exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
CSN12625 Methoxsalen   298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN14222 Khellactone 24144-61-4 Khellactone, a natural product isolated and purified from the roots of Angelica purpuraefolia with antitumor and antiplasmodial activities. It can suppress the growth of NCI-H460 tumor cells.
CSN16367 Isopimpinellin   482-27-9 Isopimpinellin is an inhibitor of 7,12-Dimethylbenz(a)anthracene which is initiator of skin tumors or breast cancers, is isolated from the roots of Pimpinella saxifraga., reported to use in the management of breast cancers.
CSN10961 Isofraxidin 486-21-5 Isofraxidin, a natural product isolated and purified from the herbs of Sarcandra glabra (Thunb.) Nakai, possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF- and the phosphorylation of p38 and ERK12.
CSN16369 Imperatorin   482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M.
CSN11055 Fraxin   524-30-1 Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC..
CSN11054 Fraxidin 525-21-3 Fraxidin is a natural product isolated and purified from the herbs of Sarcandra glabra.
CSN10170 Fraxetin 574-84-5 Fraxetin, a natural product isolated and purified from the bark of Fraxinus brngeana DC., has protective against rotenone-induced cytotoxicity, apoptotic death and antioxidant activities.
CSN10134 Dimethylfraxetin 6035-49-0 Dimethylfraxetin is a natural product isolated and purified from the herbs of Viola yedonensis Makino with anti-HRV-2 activity.
CSN10815 Dihydrocoumarin   119-84-6 Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics.
CSN13551 Demethylwedelolactone 6468-55-9 Demethylwedelolactone, a natural product isolated and purified from the herbs of Eclipta prostrata, has trypsin inhibitory effect. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells.
CSN10746 Daphnoretin 2034-69-7 Daphnoretin, a natural product isolated and purified from the roots of Wikstroemia indica (Linn.) C. A. Mey., has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin also has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way.
CSN12343 Coumestrol 479-13-0 Coumestrol, a natural product isolated and purified from the herbs of Erythrina arborescens, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 M.
CSN10701 Coumarin   91-64-5 Coumarin is a secondary phytochemical isolated and purified from the herbs of Melilotus officinalis with hepatotoxic and carcinogenic properties.
CSN14341 Cleomiscosin A 76948-72-6 Cleomiscosin A is a natural product isolated and purified from the herbs of Buxus sinica exhibiting potent anti-inflammatory activity.
CSN10014 Citropten 487-06-9 Citropten, a natural product isolated and purified from the peel of Citrus medica L., has interactions with human malignant melanoma A-2058 cells which are exposed to them.
CSN13447 Chloculol 131652-35-2 Chloculol is a natural product.
CSN10356 Auraptene     495-02-3 Auraptene is a natural product isolated and purified from the peel of Poncirus trifoliata with anti-tumor and anti-oxidant activity. Auraptene-mediated activation of JNK may contribute to the production of A by promoting -secretase activity.
CSN12221 8-Geranyloxypsoralen 7437-55-0 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus.
CSN13219 8-Geranyloxy-5,7-Dimethoxycoumarin 1228175-65-2 8-Geranyloxy-5,7-dimethoxycoumarin is a natural product isolated and purified from the herbs of Toddalia asiatica with antidiabetic and antioxidant effect.
CSN13223 (S)-Yuehgesin C 125072-68-6 8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin is a natural product isolated and purified from the herbs of Murraya paniculata.
CSN10943 7-Methoxycoumarin   531-59-9 7-Methoxycoumarin, a natural product isolated and purified from the herbs of Citrus reticulata cv. Chachiensis, has potent antioxidant effect, strong hepatoprotective activity, and weak estrogenic activity.
CSN13043 7-Hydroxy-6-Methoxy-3-Prenylcoumarin 299159-90-3 7-Hydroxy-6-methoxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13397 7-Hydroxy-3-Prenylcoumarin 86654-26-4 7-Hydroxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13282 7-Geranyloxy-6-Methoxycoumarin 28587-43-1 7-Geranyloxy-6-methoxycoumarin is a natural product isolated and purified from the herbs of Murraya tetramera Huang, showing significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1).
CSN10955 7-Amino-4-Methylcoumarin     26093-31-2 7-Amino-4-methylcoumarin is a natural product isolated and purified from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. It is also a reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye.
CSN11536 5-Methoxypsoralen   484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN13341 5,7,8-Trimethoxycoumarin 60796-65-8 5,7,8-Trimethoxycoumarin is a natural product isolated and purified from the herbs of Viola yedonensis Makino.
CSN13327 5,6,7,8-Tetramethoxycoumarin 56317-15-8 5,6,7,8-Tetramethoxycoumarin is a natural product isolated and purified from the herbs of Croton laevigatus.
CSN13076 4-Methylumbelliferone   90-33-5 4-Methylumbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
CSN13450 2-(1-Hydroxy-1-Methylethyl)-4-Methoxy-7H-Furo[3,2-G][1]benzopyran-7-One 54087-32-0 2-(1-Hydroxy-1-methylethyl)-4-methoxy-7H-furo3,2-g1benzopyran-7-one is a natural product isolated and purified from the fruits of Evodia lepta.
CSN13863 Phellopterin 2543-94-4
CSN16616 Praeruptorin D 73069-28-0
CSN10152 Isoscopoletin 776-86-3
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