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Coumarins

Coumarins

Cat. No. Product Name CAS No. Information
CSN12220 Xanthotoxol 2009-24-7 Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia.
CSN14013 Wedelolactone 524-12-9 Wedelolactone, a natural compound derived from Chinese herbal medicine Eclipta prostrate L, is an anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase II.
CSN13084 Umbelliferone   93-35-6 Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.
CSN14215 Tomentin 28449-62-9 Tomentin, a natural product isolated and purified from the barks of Jatropha curcas, can inhibit papain-like protease and has anti-inflammatory activity.
CSN13943 Suberosin 581-31-7 Suberosin, a natural product isolated and purified from the roots of Angelica pubescens, inhibits PHA-induced PBMC proliferation, at least in part, through reduction of Ca2i, ERK, NF-AT, and NF-kappaB activation, and early gene expression in PBMC including cyclins and cytokines, and arrest of cell cycle progression in the cells.
CSN13982 Sphondin 483-66-9 Sphondin, a natural product isolated and purified from the fruits of Heracleum sibiricum L., possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
CSN13328 Scopoletin Acetate 56795-51-8 Scopoletin acetate is a natural product isolated and purified from the herbs of Atropa belladonna L..
CSN16631 Scoparone   120-08-1 Scoparone, a natural product isolated and purified from the herbs of Artemisia scoparia, with antifungal, antianginal, antioxidant, immunosuppression and vasorelaxation effects, protects against carbon tetrachloride-induced liver injury, is a very efficient inhibitor of ultraviolet radiation -induced lipid peroxidation and damage, and a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.
CSN14016 Samidin 477-33-8 Samidin, a natural product isolated and purified from the fruits of Ammi visnaga., has anti-inflammatory properties through suppression of NF-B and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
CSN16448 Psoralen   66-97-7 Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity.
CSN19790 Oxypeucedanin 737-52-0 Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.
CSN13525 Notopterol   88206-46-6 Notopterol induces apoptosis and inhibits cell cycle-specific, its a natural product isolated and purified from the roots of Notopterygium incisum.
CSN19936 Nodakenin 495-31-8 Nodakenin is a natural product isolated and purified from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan. with anti-aggregatory, antibacterial, anti-allergic, anti- inflammator, and memory-enhancing effects.
CSN14208 Murrangatin 37126-91-3 Murrangatin, a natural anti-tumor-promoting agent isolated and purified from the herbs of Murraya exotica L., exhibits cytotoxicity against cholangiocarcinoma cell line and significantly inhibits EBV-EA activation, and preserves the high viability of Raji cells.
CSN14096 mMelin 15085-71-9 mMelin is a natural product isolated and purified from the herbs of Micromelum integerrimum with antitumor activity and cytotoxicity against cholangiocarcinoma cell line, KKU-100.
CSN12625 Methoxsalen   298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN14004 Meranzin Hydrate   5875-49-0 Meranzin, a natural product isolated and purified from the roots of Angelica biserrata, produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK12 pathway. Meranzin can also induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors, and exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
CSN13967 Mellein 480-33-1 Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
CSN10961 Isofraxidin 486-21-5 Isofraxidin, a natural product isolated and purified from the herbs of Sarcandra glabra (Thunb.) Nakai, possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF- and the phosphorylation of p38 and ERK12.
CSN13966 Heraclenol 31575-93-6 Heraclenol, a natural product isolated and purified from the herbs of Heracleum repula Franch, can inhibit the proliferation of melanoma cells and cell cycle.
CSN13981 Heraclenin 2880-49-1 Heraclenin, a natural product isolated and purified from the fruits of Citrus aurantium L., induces apoptosis in Jurkat leukemia cells in mechanistically different ways.
CSN11055 Fraxin   524-30-1 Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC..
CSN11054 Fraxidin 525-21-3 Fraxidin is a natural product isolated and purified from the herbs of Sarcandra glabra.
CSN10170 Fraxetin 574-84-5 Fraxetin, a natural product isolated and purified from the bark of Fraxinus brngeana DC., has protective against rotenone-induced cytotoxicity, apoptotic death and antioxidant activities.
CSN10134 Dimethylfraxetin 6035-49-0 Dimethylfraxetin is a natural product isolated and purified from the herbs of Viola yedonensis Makino with anti-HRV-2 activity.
CSN10815 Dihydrocoumarin   119-84-6 Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics.
CSN13551 Demethylwedelolactone 6468-55-9 Demethylwedelolactone, a natural product isolated and purified from the herbs of Eclipta prostrata, has trypsin inhibitory effect. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells.
CSN10746 Daphnoretin 2034-69-7 Daphnoretin, a natural product isolated and purified from the roots of Wikstroemia indica (Linn.) C. A. Mey., has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin also has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way.
CSN10701 Coumarin   91-64-5 Coumarin is a secondary phytochemical isolated and purified from the herbs of Melilotus officinalis with hepatotoxic and carcinogenic properties.
CSN10014 Citropten 487-06-9 Citropten, a natural product isolated and purified from the peel of Citrus medica L., has interactions with human malignant melanoma A-2058 cells which are exposed to them.
CSN13447 Chloculol 131652-35-2 Chloculol is a natural product.
CSN15661 Byacangelicin   482-25-7 Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
CSN10356 Auraptene     495-02-3 Auraptene is a natural product isolated and purified from the peel of Poncirus trifoliata with anti-tumor and anti-oxidant activity. Auraptene-mediated activation of JNK may contribute to the production of Aβ by promoting γ-secretase activity.
CSN12221 8-Geranyloxypsoralen 7437-55-0 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus.
CSN13219 8-Geranyloxy-5,7-Dimethoxycoumarin 1228175-65-2 8-Geranyloxy-5,7-dimethoxycoumarin is a natural product isolated and purified from the herbs of Toddalia asiatica with antidiabetic and antioxidant effect.
CSN10943 7-Methoxycoumarin   531-59-9 7-Methoxycoumarin, a natural product isolated and purified from the herbs of Citrus reticulata cv. Chachiensis, has potent antioxidant effect, strong hepatoprotective activity, and weak estrogenic activity.
CSN13397 7-Hydroxy-3-Prenylcoumarin 86654-26-4 7-Hydroxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN10955 7-Amino-4-Methylcoumarin     26093-31-2 7-Amino-4-methylcoumarin is a natural product isolated and purified from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. It is also a reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye.
CSN15033 6',7'-Dihydroxybergamottin Acetonide 684217-08-1 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans.
CSN11536 5-Methoxypsoralen   484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN13341 5,7,8-Trimethoxycoumarin 60796-65-8 5,7,8-Trimethoxycoumarin is a natural product isolated and purified from the herbs of Viola yedonensis Makino.
CSN13327 5,6,7,8-Tetramethoxycoumarin 56317-15-8 5,6,7,8-Tetramethoxycoumarin is a natural product isolated and purified from the herbs of Croton laevigatus.
CSN13450 2-(1-Hydroxy-1-Methylethyl)-4-Methoxy-7H-Furo[3,2-G][1]benzopyran-7-One 54087-32-0 2-(1-Hydroxy-1-methylethyl)-4-methoxy-7H-furo3,2-g1benzopyran-7-one is a natural product isolated and purified from the fruits of Evodia lepta.
CSN13520 (+)-Praeruptorin A 73069-27-9 ()-Praeruptorin A is a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., which exerted distinct relaxant effects on isolated rat aorta rings, which might be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase.
CSN13983 (+)-Mellein 62623-84-1 ()-Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
CSN13863 Phellopterin 2543-94-4
CSN16616 Praeruptorin D 73069-28-0
CSN14575 Marmin 14957-38-1
CSN10152 Isoscopoletin 776-86-3
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