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Complement System
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25871 | SB290157 trifluoroacetate | 1140525-25-2 | SB 290157 Trifluoroacetate is the trifluoroacetate form of SB 290157. SB 290157 is a competitive and selective C3aR (anaphylatoxin C3a receptor) antagonist. It blocked C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC(50)s of 27.7 and 28 nM, respectively. |
| CSN21412 | PMX 205 Trifluoroacetate | N/A | PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR CD88) antagonist. |
| CSN51353 | JR14a | 2411440-41-8 | JR14a is a novel potent and selective antagonist of human Complement C3a receptor. |
| CSN25566 | Danicopan | 1903768-17-1 | Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
| CSN18113 | BCX 1470 methanesulfonate | 217099-44-0 | BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC5096 nM) and C1s (IC501.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
| CSN18112 | BCX 1470 | 217099-43-9 | BCX 1470 inhibits the esterolytic activity of factor D (IC5096 nM) and C1s (IC501.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
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