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Chloride Channel
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20208 | TMEM16A Inhibitor C10bm | 2098490-06-1 | TMEM16A inhibitors C10bm contains an unusual bromodifluoroacetamide at the thiophene 2-position, had IC50 of ∼30 nM, ∼3.6-fold more potent than the most potent previously reported TMEM16A inhibitor 4 (Ani9), and > 10-fold improved metabolic stability. |
| CSN27627 | T16Ainh-A01 | 552309-42-9 | T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). |
| CSN12365 | Shikonin | 517-89-5 | Shikonin is an inhibitor of TMEM16A chloride channel with IC50 of 6.5 M, its a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc.. |
| CSN11822 | R(+)-IAA-94 | 54197-31-8 | R-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels |
| CSN22216 | NS1652 | 1566-81-0 | NS1652 is a reversible anion conductance inhibitor blocks chloride channel with an IC50 of 16 M in human and mouse red blood cells |
| CSN21767 | NPPB | 107254-86-4 | NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 M and inhibitor of cyclooxygenase IC50 8 M |
| CSN12665 | Niflumic acid | 4394-00-7 | Niflumic acid, a Ca2-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
| CSN25684 | MONNA | 1572936-83-4 | MONNA is a blocker of TMEM16A (Anoctamin-1) with IC50 of 80 nM. |
| CSN19806 | IAA-94 | 53108-00-2 | IAA-94 is an indanyloxyacetic acid IAA inhibitor of chloride channels that binds channels in bovine kidney cortex microsomes with a Ki value of 1 M |
| CSN22401 | Fluxametamide | 928783-29-3 | Fluxametamide is an insecticide with wide spectrum acts as an antagonist of GABA- and glutamate-gated chloride channels with IC50 of 195 nM and 225 nM for M domestica GABACls and GluCls |
| CSN23818 | Fluralaner | 864731-61-3 | Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. |
| CSN33111 | Endovion | 265646-85-3 | Endovion is a blocker of both VRAC and CaCC with IC50 value around 400nM for blocking swelling-activated anion currents in HEK293 cells. |
| CSN25671 | Eact | 461000-66-8 | Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). |
| CSN25670 | Ani9 | 356102-14-2 | Ani 9 is selective TMEM16A blocker with IC50 of 77 nM. |
| CSN84924 | T16A(inh)-C01 | 171506-87-9 |
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