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Chk

Chk

Cat. No. Product Name CAS No. Information
CSN16539 SCH-900776 S-Isomer 891494-64-7 SCH-900776 is the S-isomer form of SCH900776 which is a potent selective and orally bioavailable inhibitor of checkpoint kinase Chk1 IC50 3 nM highly selective against Chk2 IC50 1500 nM and cyclin-dependent kinase CDK2 IC50 160 nM
CSN20306 SAR-020106 1184843-57-9 SAR-020106 is an ATP-competitive potent and selective CHK1 inhibitor with an IC 50 of 133 nmolL on the isolated human enzyme This compound abrogates an etoposide-induced G 2 arrest with an IC 50 of 55 nmolL in HT29 cells and significantly enhances the cell killing of gemcitabine and SN38 by 30- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion
CSN26617 Prexasertib mesylate hydrate 1234015-57-6 Prexasertib, also known as LY2606368, is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
CSN26616 Prexasertib dimesylate 1234015-58-7 Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity[1][2].
CSN17165 PF-477736 952021-60-2 PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes and shows 100-fold selectivity for Chk1 than Chk2.
CSN23027 PD 407824 622864-54-4 PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50s of 47 and 97 nM respectively.
CSN23009 NSC 109555 Ditosylate 66748-43-4 NSC 109555 Ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 μM.
CSN17600 LY2606368 2HCl 1234015-54-3 LY2606368 Prexasertib is a selective Chk1 inhibitor with IC50 value 1nM modest to Chk2 and Rsk with IC50 values of 8nM and 10nM
CSN17225 Prexasertib 1234015-52-1 LY2606368 is a potent and selective ATP competitive inhibitor IC5015 nM in SW1990 cell of the Chk1 protein kinase
CSN17143 LY2603618   911222-45-2 LY2603618 is a highly selective Chk1 inhibitor with potential anti-tumor activity In a cell-free assay it shows an IC50 of 7 nM approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated
CSN21202 SB 218078 135897-06-2 Inhibitor of checkpoint kinase 1 Chk1 that displays selectivity over other protein kinases IC50 values are 15 250 and 1000 nM for Chk1 cdc2 and PKC respectively Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition Potentiates cytotoxicity of DNA-damaging drugs enhancing the efficacy of some chemotherapeutics
CSN23328 GDC-0575 1196541-47-5 GDC-0575 is a potent and selective CHK1 inhibitor.
CSN22108 CHK1 inhibitor 2097938-64-0 GDC-0575 is a potent and selective CHK1 inhibitor
CSN20165 GDC-0425 1200129-48-1 GDC-0425 is an oral selective Chk1 inhibitor GDC-0425 enhances gemcitabine gem efficacy in tumor xenograft models and shows greater chemopotentiation in cancer cell lines lacking p53 activity
CSN16590 CHIR-124 405168-58-3 CHIR-124 is a potent Chk1 inhibitor with IC50 of 03 nM with 2000-fold selectivity against Chk2 500- to 5000-fold less activity against CDK24 and Cdc2
CSN18829 CCT245737 1489389-18-5 CCT245737 is a potent ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM
CSN18925 CCT244747 1404095-34-6 CCT244747 is potent highly selective orally active ATP competitive CHK1 inhibitor with IC50 of 29-170nM
CSN17641 CCT241533 1262849-73-9 CCT241533 is a potent serinethreonine checkpoint kinase Chk2 inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 M
CSN16323 BML-277 516480-79-8 BML-277 is a selective Chk2 (checkpoint kinase 2) inhibitor with IC50 of 15 nM.
CSN15785 AZD7762 860352-01-8 AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM, being equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
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