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Cat. No.	Product Name	CAS No.	Information
CSN16539	SCH-900776 S-Isomer	891494-64-7	SCH-900776 is the S-isomer form of SCH900776 which is a potent selective and orally bioavailable inhibitor of checkpoint kinase Chk1 IC50 3 nM highly selective against Chk2 IC50 1500 nM and cyclin-dependent kinase CDK2 IC50 160 nM
CSN20306	SAR-020106	1184843-57-9	SAR-020106 is an ATP-competitive potent and selective CHK1 inhibitor with an IC 50 of 133 nmolL on the isolated human enzyme This compound abrogates an etoposide-induced G 2 arrest with an IC 50 of 55 nmolL in HT29 cells and significantly enhances the cell killing of gemcitabine and SN38 by 30- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion
CSN17165	PF-477736	952021-60-2	PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes and shows 100-fold selectivity for Chk1 than Chk2.
CSN20298	MU380	2109805-78-7	MU380 is a potent selective inhibitor of CHK1 kinase possessing unusual N-trifluoromethylpyrazole pharmacophore resistant to metabolic N-dealkylation
CSN17600	LY2606368 2HCl	1234015-54-3	LY2606368 Prexasertib is a selective Chk1 inhibitor with IC50 value 1nM modest to Chk2 and Rsk with IC50 values of 8nM and 10nM
CSN17225	LY2606368	1234015-52-1	LY2606368 is a potent and selective ATP competitive inhibitor IC5015 nM in SW1990 cell of the Chk1 protein kinase
CSN17143	LY2603618	911222-45-2	LY2603618 is a highly selective Chk1 inhibitor with potential anti-tumor activity In a cell-free assay it shows an IC50 of 7 nM approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated
CSN21202	SB 218078	135897-06-2	Inhibitor of checkpoint kinase 1 Chk1 that displays selectivity over other protein kinases IC50 values are 15 250 and 1000 nM for Chk1 cdc2 and PKC respectively Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition Potentiates cytotoxicity of DNA-damaging drugs enhancing the efficacy of some chemotherapeutics
CSN23328	GDC-0575	1196541-47-5	GDC-0575 is a potent and selective CHK1 inhibitor.
CSN22108	CHK1 inhibitor	2097938-64-0	GDC-0575 is a potent and selective CHK1 inhibitor
CSN20165	GDC-0425	1200129-48-1	GDC-0425 is an oral selective Chk1 inhibitor GDC-0425 enhances gemcitabine gem efficacy in tumor xenograft models and shows greater chemopotentiation in cancer cell lines lacking p53 activity
CSN16590	CHIR-124	405168-58-3	CHIR-124 is a potent Chk1 inhibitor with IC50 of 03 nM with 2000-fold selectivity against Chk2 500- to 5000-fold less activity against CDK24 and Cdc2
CSN18829	CCT245737	1489389-18-5	CCT245737 is a potent ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM
CSN18925	CCT244747	1404095-34-6	CCT244747 is potent highly selective orally active ATP competitive CHK1 inhibitor with IC50 of 29-170nM
CSN17641	CCT241533	1262849-73-9	CCT241533 is a potent serinethreonine checkpoint kinase Chk2 inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 M
CSN17848	CCT241533 HCl	1431697-96-9	CCT241533 hydrochloride is a potent serinethreonine checkpoint kinase Chk2 inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 M
CSN16323	BML-277	516480-79-8	BML-277 is a selective Chk2 (checkpoint kinase 2) inhibitor with IC50 of 15 nM.
CSN15785	AZD7762	860352-01-8	AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM, being equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
CSN22704	AZD 7762 HCl	1246094-78-9
CSN23009	NSC 109555 Ditosylate	66748-43-4
CSN23027	PD 407824	622864-54-4
CSN23159	TCS 2312	838823-31-7

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