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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23009 | NSC 109555 Ditosylate | 66748-43-4 | NSC 109555 Ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 μM. |
| CSN17600 | LY2606368 2HCl | 1234015-54-3 | LY2606368 Prexasertib is a selective Chk1 inhibitor with IC50 value 1nM modest to Chk2 and Rsk with IC50 values of 8nM and 10nM |
| CSN21202 | SB 218078 | 135897-06-2 | Inhibitor of checkpoint kinase 1 Chk1 that displays selectivity over other protein kinases IC50 values are 15 250 and 1000 nM for Chk1 cdc2 and PKC respectively Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition Potentiates cytotoxicity of DNA-damaging drugs enhancing the efficacy of some chemotherapeutics |
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