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CFTR

CFTR

Cat. No. Product Name CAS No. Information
CSN16162 Xipamide   14293-44-8 Xipamide a sulfonamide diuretic drug can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator CFTR chloride channel It is used for the treatment of oedema and hypertension
CSN12300 VX-809   936727-05-8 VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation with an EC50 of 0.1 M.
CSN15718 VX-661 1152311-62-0 VX-661 is a F508del CFTR corrector and is believed to help CFTR protein reach the cell surface
CSN12266 PTC-124   775304-57-9 PTC-124 is nonsense allele inhibitor used to treat Duchenne muscular dystrophy
CSN16935 PPQ-102 931706-15-9 PPQ-102 is a potent and voltage-independent CFTR inhibitor which completely inhibit CFTR chloride current with IC50 approximately 90 nM
CSN23041 PG 01 853138-65-5 PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator.
CSN11339 Lubiprostone   136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN18426 KM11060   774549-97-2 KM11060 corrects the F508del-CFTR trafficking defect also shows inhibition on PDE5 activity
CSN13698 Ivacaftor   873054-44-5 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively
CSN17491 Ivacaftor Hydrate 1134822-07-3 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively
CSN17492 Ivacaftor Benzenesulfonate 1134822-09-5 Ivacaftor benzenesulfonate is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively
CSN13745 IOWH-032 1191252-49-9 IOWH-032 is a potent CFTR inhibitor IC50101 M in T84 and CHO-CFTR cell based assays
CSN18214 GlyH-101 328541-79-3 GlyH-101 a glycinyl hydrazone compound is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 43 M
CSN21065 GLPG1837 1654725-02-6 GLPG-1837 is a cystic fibrosis transmembrane conductance regulator CFTR potentiator1 shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor
CSN23889 FDL169 1628416-28-3 FDL169 is CFTR inhibitor. It is an experimental therapy for cystic fibrosis (CF). Phase II.
CSN25267 Elexacaftor 2216712-66-0 Elexacaftor, also known as VX-445, is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.
CSN19349 CFTR(inh)-172 307510-92-5 CFTR inh-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki 300 nM
CSN22372 CFTR Corrector 1897384-89-2 CFTR corrector is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
CSN28754 Icenticaftor 1334546-77-8
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