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CDK

CDK

Cat. No. Product Name CAS No. Information
CSN17512 XL413 1169558-38-6 XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 37 nM 60-fold selectivity against CK2 10-fold selectivity against PIM and 300-fold selectivity against a panel of over 100 protein kinases
CSN16984 WHI-P180 211555-08-7 WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 40 and 10 M respectively
CSN17914 WHI-P180 HCl 153437-55-9 WHI-P180 hydrochloride is a potent EGFR and Cdk2 inhibitors with IC50 of 40 and 10 M respectively
CSN17944 THZ2 1604810-84-5 THZ2 is a potent and selective CDK7 inhibitor with in vitro IC50 of 139 nM
CSN16220 THZ1 1604810-83-4 THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 binding affinity of 32 nM and inhibits Jurkat cells proliferation with IC50 of 50 nM
CSN16121 TG-003 719277-26-6 TG003 is a potent inhibitor of Clk1Sty and Clk4 with IC50 of 15-20 nM less potency on Clk2 IC50 200 nM
CSN16666 SU9516   377090-84-1 SU9516 is a selective and potent CDK2 inhibtor with IC50 of 22 nM less potent for CDK1CDK4 IC5040200 nM and with no inhibition on PKC EGFR p38MAPK etc
CSN12378 SNS-032   345627-80-7 SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
CSN16049 SCH-900776 891494-63-6 SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively.
CSN11862 Roscovitine     186692-46-6 Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6.
CSN16564 Ro 3306 872573-93-8 Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1cyclin B1 10-fold selectivity relative to CDK2cyclin E and 50-fold relative to CDK4cyclin D
CSN16126 R547 741713-40-6 R547 is a potent ATP-competitive inhibitor of CDK124 with Ki of 2 nM3 nM1 nM
CSN11800 Purvalanol A 212844-53-6 Purvalanol A is a selective inhibitor of cyclin-dependent kinases CDKs it potently inhibits cdc2cyclin B Cdk2cyclin A Cdk2cyclin E Cdk4cyclin D1 and Cdk5-p35 with IC50 values of 4 70 35 850 and 75 nM respectively
CSN12713 PHA-848125 802539-81-7 PHA-848125 is a potent ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM being 3-fold selective for CDK2 than CDK1 2 4 5 and 7
CSN17186 PHA-793887   718630-59-2 PHA-793887 is a pan-cdk inhibitor inhibits cdk124579 with IC50s of 5 - 140 nM
CSN16230 PHA-767491 845714-00-3 PHA-767491 is a potent ATP-competitive dual Cdc7Cdk9 inhibitor with IC50 values of 1034 nM and also an inhibitor of NRF2
CSN12418 Palbociclib   571190-30-2 Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM
CSN15851 Palbociclib HCl     827022-32-2 Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN16662 P276-00 920113-03-7 P276-00 is a CDK1 CDK4 and CDK9 inhibitor with IC50 of 79 nM 63 nM and 20 nM respectively
CSN17748 ON 123300   1357470-29-1 ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4 Ark5 PDGFR FGFR1 RET and Fyn with IC50 of 39 nM 5 nM 26 nM 26 nM 92 nM and 11nM respectively
CSN18553 NVP-LCQ195 902156-99-4 NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
CSN16279 NG 52 212779-48-1 NG 52 is a potent cell-permeable reversible selective and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p IC50 7 M and the related Pho85p kinase IC50 2 M
CSN17183 ML167 1285702-20-6 ML167 is a highly selective Cdc2-like kinase 4 Clk4 inhibitor with IC50 of 136 nM showing 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A1B
CSN23650 ML 315 HCl 1440251-53-5 ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B.
CSN17957 LY2857785 1619903-54-6 LY2857785 is a potent and selective CDK9 inhibitor and significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines
CSN17759 LEE011 Succinate   1374639-75-4 LEE011 Succinate is an orally available cyclin-dependent kinase CDK inhibitor with highly selective for cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway and potential antineoplastic activity
CSN17760 LEE011 Succinate Hydrate 1374639-79-8 LEE011 succinate is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity
CSN15813 LEE011     1211441-98-3 LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN17570 LEE011 HCl   1211443-80-9 LEE011 hydrochloride is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity
CSN17741 KH-CB19 1354037-26-5 KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 CLK1CLK4
CSN12858 JNJ-7706621   443797-96-4 JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK12 with IC50 of 94 nM also potently inhibits Aurora AB
CSN11014 Flavopiridol 146426-40-6 Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively
CSN11015 Flavopiridol HCl 131740-09-5 Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of 40 nM.
CSN18431 Dinaciclib     779353-01-4 Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
CSN16417 CVT-313   199986-75-9 CVT-313 is a potent selective ATP-competitive and reversible inhibitor of CDK2 with IC50 of 05 M for Cdk2A and Cdk2E 42 M for Cdk1B 215 M for Cdk4D1
CSN17780 CDK9-IN-6 1391855-95-0 CDK9-IN-6 is a CDK9 inhibito
CSN17642 CDK9-IN-2 1263369-28-3 CDK9-IN-2 is a special cyclin-dependent kinase 9 CDK9 inhibitor with an IC50 of 5 nM and 7 nM in H929 multiple myelomaMM cell line 72 hours and A2058 skin cell line 72 hours respectively
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN17649 CDK-IN-2 1269815-17-9 CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of 8 nM
CSN17151 BS-181 HCl 1397219-81-6 BS-181 is a selective CDK7 inhibitor with IC50 of 21 nM
CSN17259 Briciclib 865783-99-9 Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells
CSN20540 BRD6989 642008-81-9 BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity.
CSN16547 BMS-265246 582315-72-8 BMS-265246 is a potent and selective CDK12 inhibitor for CDK1cyclin B and CDK2cyclin E with IC50 of 6 and 9 nM respectively
CSN16208 AT7519   844442-38-2 AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively.
CSN16210 AT7519 HCl   902135-91-5 AT7519 hydrochloride is a multi-CDK inhibitor for CDK1 2 4 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7
CSN17844 AT7519 Trifluoroacetate 1431697-85-6 AT 7519 trifluoroacetate is a multi-CDK inhibitor for CDK1 2 4 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7
CSN15832 AMG-925 1401033-86-0 AMG-925 is a potent and selective dual inhibtor of CDK4FLT3 with IC50s of 15 nM and 24 nM for CDK4 and FLT3 respectively and with IC50 of 19 nM in MOLM-13 cell
CSN13886 LY2835219     1231930-82-7 Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15805 Abemaciclib   1231929-97-7 Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15942 1NM-PP1(PP1 Analog II) 221244-14-0 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 M for vSrc and 42 nM for v-Src-as1 I338G
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