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CDK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17512 | XL413 | 1169558-38-6 | XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 37 nM 60-fold selectivity against CK2 10-fold selectivity against PIM and 300-fold selectivity against a panel of over 100 protein kinases |
| CSN16440 | Wogonin | 632-85-9 | Wogonin acts as an inhibitor of COX2 with IC50 of 46 M without affecting COX-1 and inhibits the NF-B pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi. |
| CSN17914 | WHI-P180 HCl | 153437-55-9 | WHI-P180 HCl is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 μM, respectively. |
| CSN24147 | Voruciclib | 1000023-04-0 | Voruciclib is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity. |
| CSN22094 | Trilaciclib HCl | 1977495-97-8 | Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. |
| CSN16220 | THZ1 | 1604810-83-4 | THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 binding affinity of 32 nM and inhibits Jurkat cells proliferation with IC50 of 50 nM |
| CSN22287 | THAL-SNS-032 | 2139287-33-3 | THAL-SNS-032 is a selective PROTAC, consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN), targeting on CDK9. |
| CSN16121 | TG-003 | 719277-26-6 | TG003 is a potent inhibitor of Clk1Sty and Clk4 with IC50 of 15-20 nM less potency on Clk2 IC50 200 nM |
| CSN12378 | SNS-032 | 345627-80-7 | SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
| CSN23869 | Senexin B | 1449228-40-3 | Senexin B is a potent and selective CDK8/19 inhibitor. |
| CSN11862 | Roscovitine | 186692-46-6 | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6. |
| CSN16126 | R547 | 741713-40-6 | R547 is a potent ATP-competitive inhibitor of CDK124 with Ki of 2 nM3 nM1 nM |
| CSN11800 | Purvalanol A | 212844-53-6 | Purvalanol A is a selective inhibitor of cyclin-dependent kinases CDKs it potently inhibits cdc2cyclin B Cdk2cyclin A Cdk2cyclin E Cdk4cyclin D1 and Cdk5-p35 with IC50 values of 4 70 35 850 and 75 nM respectively |
| CSN22310 | CDK9-PROTAC | 2118356-96-8 | PROTAC CDK9 Degrader-1 is a CRBN-recruiting PROTAC selectively targeting on CDK9, consist of a CDK9 ligand (aminopyrazole analog) linked to a CRBN E3 ligand thalidomide. |
| CSN12713 | PHA-848125 | 802539-81-7 | PHA-848125 is a potent ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM being 3-fold selective for CDK2 than CDK1 2 4 5 and 7 |
| CSN17186 | PHA-793887 | 718630-59-2 | PHA-793887 is a pan-cdk inhibitor inhibits cdk124579 with IC50s of 5 - 140 nM |
| CSN16230 | PHA-767491 | 845714-00-3 | PHA-767491 is a potent ATP-competitive dual Cdc7Cdk9 inhibitor with IC50 values of 1034 nM and also an inhibitor of NRF2 |
| CSN24146 | PF-06873600 | 2185857-97-8 | PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6 respectively. PF-06873600 has potential antineoplastic activity. |
| CSN12418 | Palbociclib | 571190-30-2 | Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM |
| CSN15851 | Palbociclib HCl | 827022-32-2 | Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. |
| CSN17748 | ON 123300 | 1357470-29-1 | ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4 Ark5 PDGFR FGFR1 RET and Fyn with IC50 of 39 nM 5 nM 26 nM 26 nM 92 nM and 11nM respectively |
| CSN18553 | NVP-LCQ195 | 902156-99-4 | NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. |
| CSN16279 | NG 52 | 212779-48-1 | NG 52 is a potent cell-permeable reversible selective and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p IC50 7 M and the related Pho85p kinase IC50 2 M |
| CSN23650 | ML 315 | 1440251-53-5 | ML 315 is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B. |
| CSN23665 | ML 315 HCl | 2172559-91-8 | ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B. |
| CSN24194 | MC180295 | 2237942-08-2 | MC180295 is a selective CDK9 inhibitor with IC50 values of 5nM, 112nM, 138nM, 159nM, 186nM, 233nM, 367nM, 399nM, 555nM and 712nM for CDK9-Cyclin T1, CDK4-Cyclin D, CDK1-Cyclin B, cdk5-p35, cdk5-p25, cdk2-cyclin A, cdk2-cyclin E, CDK3-Cyclin E, CDK7-CycH/MAT1 and cdk6-cyclin D3. |
| CSN17759 | LEE011 Succinate | 1374639-75-4 | LEE011 Succinate is an orally available cyclin-dependent kinase CDK inhibitor with highly selective for cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway and potential antineoplastic activity |
| CSN17760 | LEE011 Succinate Hydrate | 1374639-79-8 | LEE011 succinate is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity |
| CSN17570 | LEE011 HCl | 1211443-80-9 | LEE011 HCl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
| CSN17741 | KH-CB19 | 1354037-26-5 | KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 CLK1CLK4 |
| CSN22284 | JH-XI-10-02 | 2209085-22-1 | JH-XI-10-02 is a PROTAC selectively targeting on CDK8 with IC50 value of 159nM, and is consist of a warhead target on CDK8 (a Cortistatin A derivate) linked to CRBN ligand Pomalidomide. |
| CSN11014 | Flavopiridol | 146426-40-6 | Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively |
| CSN11015 | Flavopiridol HCl | 131740-09-5 | Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. |
| CSN18431 | Dinaciclib | 779353-01-4 | Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
| CSN16417 | CVT-313 | 199986-75-9 | CVT-313 is a potent selective ATP-competitive and reversible inhibitor of CDK2 with IC50 of 05 M for Cdk2A and Cdk2E 42 M for Cdk1B 215 M for Cdk4D1 |
| CSN10712 | Cucurbitacin E | 18444-66-1 | Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis. |
| CSN17780 | CDK9-IN-6 | 1391855-95-0 | CDK9-IN-6 is a CDK9 inhibito |
| CSN22367 | CDK8-IN-3 | 1884500-15-5 | CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. |
| CSN17795 | Ca2+ Channel Agonist 1 | 1402821-24-2 | Ca2 channel agonist 1 is a N-type Ca2 channel activity agonist with EC50 of 1423 M also inhibits cdk2 kinase activity with EC50 of 334 M |
| CSN17259 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells |
| CSN20540 | BRD6989 | 642008-81-9 | BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity. |
| CSN24735 | AZD4573 | 2057509-72-3 | AZD4573 is a potent and selective CDK9 inhibitor with with nanomolar. |
| CSN16208 | AT7519 | 844442-38-2 | AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively. |
| CSN16210 | AT7519 HCl | 902135-91-5 | AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7. |
| CSN13886 | LY2835219 | 1231930-82-7 | Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
| CSN15805 | Abemaciclib | 1231929-97-7 | Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
| CSN15942 | 1NM-PP1(PP1 Analog II) | 221244-14-0 | 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 M for vSrc and 42 nM for v-Src-as1 I338G |
| CSN23674 | SEL120-34A HCl | 1609452-30-3 | |
| CSN23778 | cc671 | 1618658-88-0 |
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