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CDK

CDK

Cat. No. Product Name CAS No. Information
CSN17512 XL413 1169558-38-6 XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 37 nM 60-fold selectivity against CK2 10-fold selectivity against PIM and 300-fold selectivity against a panel of over 100 protein kinases
CSN16440 Wogonin   632-85-9 Wogonin acts as an inhibitor of COX2 with IC50 of 46 M without affecting COX-1 and inhibits the NF-B pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi.
CSN17914 WHI-P180 HCl 153437-55-9 WHI-P180 HCl is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 μM, respectively.
CSN24147 Voruciclib 1000023-04-0 Voruciclib is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity.
CSN22094 Trilaciclib HCl 1977495-97-8 Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively.
CSN16220 THZ1 1604810-83-4 THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 binding affinity of 32 nM and inhibits Jurkat cells proliferation with IC50 of 50 nM
CSN22287 THAL-SNS-032 2139287-33-3 THAL-SNS-032 is a selective PROTAC, consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN), targeting on CDK9.
CSN16121 TG-003 719277-26-6 TG003 is a potent inhibitor of Clk1Sty and Clk4 with IC50 of 15-20 nM less potency on Clk2 IC50 200 nM
CSN12378 SNS-032   345627-80-7 SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
CSN23869 Senexin B 1449228-40-3 Senexin B is a potent and selective CDK8/19 inhibitor.
CSN11862 Roscovitine     186692-46-6 Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6.
CSN16126 R547 741713-40-6 R547 is a potent ATP-competitive inhibitor of CDK124 with Ki of 2 nM3 nM1 nM
CSN11800 Purvalanol A 212844-53-6 Purvalanol A is a selective inhibitor of cyclin-dependent kinases CDKs it potently inhibits cdc2cyclin B Cdk2cyclin A Cdk2cyclin E Cdk4cyclin D1 and Cdk5-p35 with IC50 values of 4 70 35 850 and 75 nM respectively
CSN22310 CDK9-PROTAC 2118356-96-8 PROTAC CDK9 Degrader-1 is a CRBN-recruiting PROTAC selectively targeting on CDK9, consist of a CDK9 ligand (aminopyrazole analog) linked to a CRBN E3 ligand thalidomide.
CSN12713 PHA-848125 802539-81-7 PHA-848125 is a potent ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM being 3-fold selective for CDK2 than CDK1 2 4 5 and 7
CSN17186 PHA-793887   718630-59-2 PHA-793887 is a pan-cdk inhibitor inhibits cdk124579 with IC50s of 5 - 140 nM
CSN16230 PHA-767491 845714-00-3 PHA-767491 is a potent ATP-competitive dual Cdc7Cdk9 inhibitor with IC50 values of 1034 nM and also an inhibitor of NRF2
CSN24146 PF-06873600 2185857-97-8 PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6 respectively. PF-06873600 has potential antineoplastic activity.
CSN12418 Palbociclib   571190-30-2 Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM
CSN15851 Palbociclib HCl     827022-32-2 Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN17748 ON 123300   1357470-29-1 ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4 Ark5 PDGFR FGFR1 RET and Fyn with IC50 of 39 nM 5 nM 26 nM 26 nM 92 nM and 11nM respectively
CSN18553 NVP-LCQ195 902156-99-4 NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
CSN16279 NG 52 212779-48-1 NG 52 is a potent cell-permeable reversible selective and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p IC50 7 M and the related Pho85p kinase IC50 2 M
CSN23650 ML 315 1440251-53-5 ML 315 is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B.
CSN23665 ML 315 HCl 2172559-91-8 ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B.
CSN24194 MC180295 2237942-08-2 MC180295 is a selective CDK9 inhibitor with IC50 values of 5nM, 112nM, 138nM, 159nM, 186nM, 233nM, 367nM, 399nM, 555nM and 712nM for CDK9-Cyclin T1, CDK4-Cyclin D, CDK1-Cyclin B, cdk5-p35, cdk5-p25, cdk2-cyclin A, cdk2-cyclin E, CDK3-Cyclin E, CDK7-CycH/MAT1 and cdk6-cyclin D3.
CSN17759 LEE011 Succinate   1374639-75-4 LEE011 Succinate is an orally available cyclin-dependent kinase CDK inhibitor with highly selective for cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway and potential antineoplastic activity
CSN17760 LEE011 Succinate Hydrate 1374639-79-8 LEE011 succinate is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity
CSN17570 LEE011 HCl   1211443-80-9 LEE011 HCl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN17741 KH-CB19 1354037-26-5 KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 CLK1CLK4
CSN22284 JH-XI-10-02 2209085-22-1 JH-XI-10-02 is a PROTAC selectively targeting on CDK8 with IC50 value of 159nM, and is consist of a warhead target on CDK8 (a Cortistatin A derivate) linked to CRBN ligand Pomalidomide.
CSN11014 Flavopiridol 146426-40-6 Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively
CSN11015 Flavopiridol HCl 131740-09-5 Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM.
CSN18431 Dinaciclib     779353-01-4 Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
CSN16417 CVT-313   199986-75-9 CVT-313 is a potent selective ATP-competitive and reversible inhibitor of CDK2 with IC50 of 05 M for Cdk2A and Cdk2E 42 M for Cdk1B 215 M for Cdk4D1
CSN10712 Cucurbitacin E 18444-66-1 Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis.
CSN17780 CDK9-IN-6 1391855-95-0 CDK9-IN-6 is a CDK9 inhibito
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN17795 Ca2+ Channel Agonist 1 1402821-24-2 Ca2 channel agonist 1 is a N-type Ca2 channel activity agonist with EC50 of 1423 M also inhibits cdk2 kinase activity with EC50 of 334 M
CSN17259 Briciclib 865783-99-9 Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells
CSN20540 BRD6989 642008-81-9 BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity.
CSN24735 AZD4573 2057509-72-3 AZD4573 is a potent and selective CDK9 inhibitor with with nanomolar.
CSN16208 AT7519   844442-38-2 AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively.
CSN16210 AT7519 HCl   902135-91-5 AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7.
CSN13886 LY2835219     1231930-82-7 Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15805 Abemaciclib   1231929-97-7 Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15942 1NM-PP1(PP1 Analog II) 221244-14-0 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 M for vSrc and 42 nM for v-Src-as1 I338G
CSN23674 SEL120-34A HCl 1609452-30-3
CSN23778 cc671 1618658-88-0
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