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CDK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17512 | XL413 | 1169558-38-6 | XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 37 nM 60-fold selectivity against CK2 10-fold selectivity against PIM and 300-fold selectivity against a panel of over 100 protein kinases |
| CSN16984 | WHI-P180 | 211555-08-7 | WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 40 and 10 M respectively |
| CSN17914 | WHI-P180 HCl | 153437-55-9 | WHI-P180 hydrochloride is a potent EGFR and Cdk2 inhibitors with IC50 of 40 and 10 M respectively |
| CSN17944 | THZ2 | 1604810-84-5 | THZ2 is a potent and selective CDK7 inhibitor with in vitro IC50 of 139 nM |
| CSN16220 | THZ1 | 1604810-83-4 | THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 binding affinity of 32 nM and inhibits Jurkat cells proliferation with IC50 of 50 nM |
| CSN16121 | TG-003 | 719277-26-6 | TG003 is a potent inhibitor of Clk1Sty and Clk4 with IC50 of 15-20 nM less potency on Clk2 IC50 200 nM |
| CSN16666 | SU9516 | 377090-84-1 | SU9516 is a selective and potent CDK2 inhibtor with IC50 of 22 nM less potent for CDK1CDK4 IC5040200 nM and with no inhibition on PKC EGFR p38MAPK etc |
| CSN12378 | SNS-032 | 345627-80-7 | SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
| CSN16049 | SCH-900776 | 891494-63-6 | SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively. |
| CSN11862 | Roscovitine | 186692-46-6 | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6. |
| CSN16564 | Ro 3306 | 872573-93-8 | Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1cyclin B1 10-fold selectivity relative to CDK2cyclin E and 50-fold relative to CDK4cyclin D |
| CSN16126 | R547 | 741713-40-6 | R547 is a potent ATP-competitive inhibitor of CDK124 with Ki of 2 nM3 nM1 nM |
| CSN11800 | Purvalanol A | 212844-53-6 | Purvalanol A is a selective inhibitor of cyclin-dependent kinases CDKs it potently inhibits cdc2cyclin B Cdk2cyclin A Cdk2cyclin E Cdk4cyclin D1 and Cdk5-p35 with IC50 values of 4 70 35 850 and 75 nM respectively |
| CSN12713 | PHA-848125 | 802539-81-7 | PHA-848125 is a potent ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM being 3-fold selective for CDK2 than CDK1 2 4 5 and 7 |
| CSN17186 | PHA-793887 | 718630-59-2 | PHA-793887 is a pan-cdk inhibitor inhibits cdk124579 with IC50s of 5 - 140 nM |
| CSN16230 | PHA-767491 | 845714-00-3 | PHA-767491 is a potent ATP-competitive dual Cdc7Cdk9 inhibitor with IC50 values of 1034 nM and also an inhibitor of NRF2 |
| CSN12418 | Palbociclib | 571190-30-2 | Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM |
| CSN15851 | Palbociclib HCl | 827022-32-2 | Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. |
| CSN16662 | P276-00 | 920113-03-7 | P276-00 is a CDK1 CDK4 and CDK9 inhibitor with IC50 of 79 nM 63 nM and 20 nM respectively |
| CSN17748 | ON 123300 | 1357470-29-1 | ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4 Ark5 PDGFR FGFR1 RET and Fyn with IC50 of 39 nM 5 nM 26 nM 26 nM 92 nM and 11nM respectively |
| CSN18553 | NVP-LCQ195 | 902156-99-4 | NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. |
| CSN16279 | NG 52 | 212779-48-1 | NG 52 is a potent cell-permeable reversible selective and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p IC50 7 M and the related Pho85p kinase IC50 2 M |
| CSN17183 | ML167 | 1285702-20-6 | ML167 is a highly selective Cdc2-like kinase 4 Clk4 inhibitor with IC50 of 136 nM showing 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A1B |
| CSN23650 | ML 315 HCl | 1440251-53-5 | ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B. |
| CSN17957 | LY2857785 | 1619903-54-6 | LY2857785 is a potent and selective CDK9 inhibitor and significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines |
| CSN17759 | LEE011 Succinate | 1374639-75-4 | LEE011 Succinate is an orally available cyclin-dependent kinase CDK inhibitor with highly selective for cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway and potential antineoplastic activity |
| CSN17760 | LEE011 Succinate Hydrate | 1374639-79-8 | LEE011 succinate is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity |
| CSN15813 | LEE011 | 1211441-98-3 | LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
| CSN17570 | LEE011 HCl | 1211443-80-9 | LEE011 hydrochloride is an orally available cyclin-dependent kinase CDK inhibitor targeting cyclin D1CDK4 and cyclin D3CDK6 cell cycle pathway with potential antineoplastic activity |
| CSN17741 | KH-CB19 | 1354037-26-5 | KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 CLK1CLK4 |
| CSN12858 | JNJ-7706621 | 443797-96-4 | JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK12 with IC50 of 94 nM also potently inhibits Aurora AB |
| CSN11014 | Flavopiridol | 146426-40-6 | Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively |
| CSN11015 | Flavopiridol HCl | 131740-09-5 | Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of 40 nM. |
| CSN18431 | Dinaciclib | 779353-01-4 | Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
| CSN16417 | CVT-313 | 199986-75-9 | CVT-313 is a potent selective ATP-competitive and reversible inhibitor of CDK2 with IC50 of 05 M for Cdk2A and Cdk2E 42 M for Cdk1B 215 M for Cdk4D1 |
| CSN17780 | CDK9-IN-6 | 1391855-95-0 | CDK9-IN-6 is a CDK9 inhibito |
| CSN17642 | CDK9-IN-2 | 1263369-28-3 | CDK9-IN-2 is a special cyclin-dependent kinase 9 CDK9 inhibitor with an IC50 of 5 nM and 7 nM in H929 multiple myelomaMM cell line 72 hours and A2058 skin cell line 72 hours respectively |
| CSN22367 | CDK8-IN-3 | 1884500-15-5 | CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. |
| CSN17649 | CDK-IN-2 | 1269815-17-9 | CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of 8 nM |
| CSN17151 | BS-181 HCl | 1397219-81-6 | BS-181 is a selective CDK7 inhibitor with IC50 of 21 nM |
| CSN17259 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells |
| CSN20540 | BRD6989 | 642008-81-9 | BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity. |
| CSN16547 | BMS-265246 | 582315-72-8 | BMS-265246 is a potent and selective CDK12 inhibitor for CDK1cyclin B and CDK2cyclin E with IC50 of 6 and 9 nM respectively |
| CSN16208 | AT7519 | 844442-38-2 | AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively. |
| CSN16210 | AT7519 HCl | 902135-91-5 | AT7519 hydrochloride is a multi-CDK inhibitor for CDK1 2 4 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7 |
| CSN17844 | AT7519 Trifluoroacetate | 1431697-85-6 | AT 7519 trifluoroacetate is a multi-CDK inhibitor for CDK1 2 4 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7 |
| CSN15832 | AMG-925 | 1401033-86-0 | AMG-925 is a potent and selective dual inhibtor of CDK4FLT3 with IC50s of 15 nM and 24 nM for CDK4 and FLT3 respectively and with IC50 of 19 nM in MOLM-13 cell |
| CSN13886 | LY2835219 | 1231930-82-7 | Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
| CSN15805 | Abemaciclib | 1231929-97-7 | Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
| CSN15942 | 1NM-PP1(PP1 Analog II) | 221244-14-0 | 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 M for vSrc and 42 nM for v-Src-as1 I338G |
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