Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
|Cat. No.||Product Name||CAS No.||Information|
|CSN27190||CD80-IN-3||486449-65-4||CD80-IN-3 binds with high specificity and low nanomolar affinity to CD80. It has relatively slow off-rates, blocks both CD28 and CTLA-4 binding and inhibits proinflammatory cytokine release in T cell assays with submicromolar potency.|