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Cathepsin

Cathepsin

Cat. No. Product Name CAS No. Information
CSN17677 VBY-825 1310340-58-9 VBY-825 is a reversible cathepsin inhibitor with high potency against cathepsins B L S and V
CSN25645 Relacatib 362505-84-8 Relacatib is developed as a cathepsin K inhibitor but has activity against cathepsin L that may provide potential to block SARS-Cov-2 entry into host cells.
CSN20340 ONO-5334 868273-90-9 ONO-5334 is a potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively).
CSN13484 Odanacatib   603139-19-1 Odanacatib is a potent selective and neutral inhibitor of cathepsin K humanrabbit with IC50 of 02 nM1 nM and demonstrated high selectivity versus off-target cathepsin B L S
CSN22465 MIV-247 1352817-76-5 MIV-247 is a selective cathepsin S inhibitor with Kis of 21 42 and 75 nM for human mouse and cynomolgus monkey cathepsin S respectively
CSN10529 MG-101 110044-82-1 MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki 190 nM), calpain II (Ki 220 nM), cathepsin B (Ki 150 nM), and cathepsin L (Ki 500 pM).
CSN20392 MDL28170 88191-84-8 MDL28170 is a potent selective inhibitor of calpain and cathepsin B Ki values are 10 and 25 nM respectively that does not inhibit trypsin-like serine proteases MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo
CSN17758 LY3000328 1373215-15-6 LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.75.85 nM and 1.671.17 nM for hCat S and mCat S respectively, can be used in treatment for abdominal aortic aneurysm.
CSN17411 Leupeptin Hemisulfate 103476-89-7 Leupeptin Hemisulfate is a reversible serinecysteine protease inhibitor inhibits cathepsins B H L and S calpain and trypsin
CSN22874 L 006235 294623-49-7 L 006235 is a potent, reversible cathepsin K inhibitor with IC50 of 0.25 nM.
CSN13069 Furan-2-Carboxylic Acid   88-14-2 Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.
CSN23117 SID 26681509 958772-66-2 Cathepsin L inhibitor
CSN22995 Calpain Inhibitor II 145757-50-2 Calpain Inhibitor II is an inhibitor of calpain.
CSN16115 CA-074 Methyl Ester 147859-80-1 CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
CSN22735 CA 074 134448-10-5 CA 074 is an inhibitor of cathepsin B with Ki of 2 - 5 nM.
CSN16928 Balicatib 354813-19-7 Balicatib is a potent and selective inhibitor of cathepsin K with 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B L and S
CSN19675 AZD7986 1802148-05-5 AZD7986 is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing.
CSN22577 5,5-Dimethyl-2,4-oxazolidinedione   695-53-4 5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, its an anticonvulsant.
CSN14152 1-Hydroxyrutaecarpine 53600-24-1 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL.
CSN25375 2-cyano-Pyrimidine 14080-23-0
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