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Cathepsin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17677 | VBY-825 | 1310340-58-9 | VBY-825 is a reversible cathepsin inhibitor with high potency against cathepsins B L S and V |
| CSN25645 | Relacatib | 362505-84-8 | Relacatib is developed as a cathepsin K inhibitor but has activity against cathepsin L that may provide potential to block SARS-Cov-2 entry into host cells. |
| CSN25351 | Petesicatib | 1252637-35-6 | Petesicatib is a cathepsin S inhibitor, used in immune diseases research. |
| CSN20340 | ONO-5334 | 868273-90-9 | ONO-5334 is a potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). |
| CSN13484 | Odanacatib | 603139-19-1 | Odanacatib is a potent selective and neutral inhibitor of cathepsin K humanrabbit with IC50 of 02 nM1 nM and demonstrated high selectivity versus off-target cathepsin B L S |
| CSN22465 | MIV-247 | 1352817-76-5 | MIV-247 is a selective cathepsin S inhibitor with Kis of 21 42 and 75 nM for human mouse and cynomolgus monkey cathepsin S respectively |
| CSN10529 | MG-101 | 110044-82-1 | MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki 190 nM), calpain II (Ki 220 nM), cathepsin B (Ki 150 nM), and cathepsin L (Ki 500 pM). |
| CSN20392 | MDL-28170 | 88191-84-8 | MDL28170 is a potent selective inhibitor of calpain and cathepsin B Ki values are 10 and 25 nM respectively that does not inhibit trypsin-like serine proteases MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo |
| CSN17758 | LY 3000328 | 1373215-15-6 | LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.75.85 nM and 1.671.17 nM for hCat S and mCat S respectively, can be used in treatment for abdominal aortic aneurysm. |
| CSN17411 | Leupeptin hemisulfate | 103476-89-7 | Leupeptin Hemisulfate is a reversible serinecysteine protease inhibitor inhibits cathepsins B H L and S calpain and trypsin |
| CSN27215 | L-Homocysteine | 6027-13-0 | L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia . |
| CSN22874 | L-006235 | 294623-49-7 | L 006235 is a potent, reversible cathepsin K inhibitor with IC50 of 0.25 nM. |
| CSN13069 | 2-Furoic acid | 88-14-2 | Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis. |
| CSN23117 | SID 26681509 | 958772-66-2 | Cathepsin L inhibitor |
| CSN22995 | Calpain Inhibitor II | 145757-50-2 | Calpain Inhibitor II is an inhibitor of calpain. |
| CSN16115 | CA-074 methyl ester | 147859-80-1 | CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
| CSN22735 | CA-074 | 134448-10-5 | CA 074 is an inhibitor of cathepsin B with Ki of 2 - 5 nM. |
| CSN16928 | Balicatib | 354813-19-7 | Balicatib is a potent and selective inhibitor of cathepsin K with 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B L and S |
| CSN19675 | Brensocatib | 1802148-05-5 | AZD7986 is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. |
| CSN22577 | Dimethadione | 695-53-4 | 5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, its an anticonvulsant. |
| CSN25375 | 2-Cyanopyrimidine | 14080-23-0 | 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos. |
| CSN14152 | 1-Hydroxyrutecarpine | 53600-24-1 | 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL. |
| CSN62577 | Z-FY-CHO | 167498-29-5 |
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