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Caspase

Caspase

Cat. No. Product Name CAS No. Information
CSN26605 Z-WEHD-FMK 210345-00-9 Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].
CSN15936 Z-VAD(OMe)-FMK 187389-52-2 Z-VADOMe-FMK is a cell-permeable irreversible broad-spectrum caspase inhibitor blocks all features of apoptosis
CSN19230 Z-VAD-FMK 161401-82-7 Z-VAD-FMK is an irreversible pan-caspase inhibitor
CSN13841 Z-IETD-FMK 210344-98-2 Z-IETD-FMK is a specific Caspase-8 inhibitor
CSN18102 Z-DEVD-FMK 210344-95-9 Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner.
CSN15837 VX-765 273404-37-8 VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay.
CSN21899 Ubiquitin Isopeptidase Inhibitor I, G5 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 is an apoptosome-independent caspase and apoptosis activator.
CSN27386 Taurodeoxycholic acid sodium hydrate 110026-03-4 Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid sodium hydrate is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
CSN26187 5-(((1R,3aR,4S,6aR)-4-(Benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan-1-yl)oxy)benzo[d][1,3]dioxole 526-07-8 Sesamolin is a furofuran lignan extracted from sesame seeds, which has beneficial physiological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. It was also found to inhibit lipid peroxidation in rat liver and kidney.
CSN17276 Q-VD-OPh   1135695-98-5 Q-VD-OPh is a potent pan-caspase inhibitor of caspases 1, 3, 8, and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
CSN15961 N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide 315183-21-2 PAC-1 is a potent procaspase-3 activator with EC50 of 022 M which activate procaspase-3 to caspase-3 and induces apoptotic death in cancer cells in culture and in mouse xenograft models
CSN22466 ML132 1230628-71-3 ML132 is a potent and selective caspase 1 inhibitor with an IC50 of 0316 nM
CSN12697 Emricasan 254750-02-2 Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro.
CSN27752 N-(3-(Imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide 1100353-03-4 CASP3 Activator 1541 is an activator of procaspase-3.
CSN18370 BOC-D-FMK 634911-80-1 BOC-D-FMK is a pan-caspase inhibitor
CSN19256 Ossirene   106566-58-9 AS101 is a potent Caspase-1 inhibitor which can inhibit IL-10 synthesis and potentiates IL-1 IL-2 and TNF- release through Caspase performing as an immunomodulator
CSN27236 Ac-YVAD-cmk   178603-78-6 Ac-YVAD-CMK is a tetrapeptide ICE inhibitor.
CSN23216 Ac-DEVD-CHO 169332-60-9 Ac-DEVD-CHO is a potent and specific Caspase-3 inhibitor with Ki of 230 pM.
CSN24780 2-HBA   131359-24-5 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
CSN33193 Pralnacasan 192755-52-5
CSN68548 SDZ 224-015 161511-45-1
CSN76206 Z-DEVD-AFC 1135416-11-3
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