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Cardiovascular Disease

Cat. No. Product Name CAS No. Information
CSN16080 BIO 667463-62-9 BIO is an inhibitor of GSK-3 and CDK1cyclinB complex. The IC50s of GSK-3, CDK1, CDK5 are 5 nM, 320 nM and 83 nM, respectively.
CSN12478 Nateglinide 105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN18971 ONO-7300243 638132-34-0 ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.
CSN12647 Diazoxide 364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN16171 Prasugrel 150322-43-3 Prasugrel is a platelet inhibitor with IC50 value of 1.8 M.
CSN10332 Argatroban Monohydrate 141396-28-3 Argatroban is an inhibitor of thrombin.
CSN16825 NS-304 475086-01-2 NS-304 is an agonist of prostacyclin IP1 receptor with Ki of 260 nM. It is used for the treatment of pulmonary arterial hypertension.
CSN10068 Ajmaline 4360-12-7 Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.
CSN11508 Nafamostat Mesylate 82956-11-4 Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity.
CSN12923 Cilostazol 73963-72-1 Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 M and inhibitor of adenosine uptake.
CSN12296 Eltrombopag 496775-61-2 Eltrombopag is an agonist of thrombopoietin-receptor (TpoR) and can stimulate thrombopoiesis.
CSN21291 ML171 6631-94-3 ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 M for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system.
CSN12826 Ticagrelor 274693-27-5 Ticagrelor is a reversibly and oral active P2Y12 receptor antagonist with Ki of 2 nM, also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 M and 8.2 M respectively.
CSN11335 Lovastatin 75330-75-5 Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.
CSN12549 Cinnarizine 298-57-7 Cinnarizine, an antihistamine, can block calcium channel and promote cerebral blood flow. It is used to treat post-trauma cerebral symptoms and cerebral arteriosclerosis.
CSN12204 Vinpocetine 42971-09-5 Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 M, it also blocks voltage-gated Na channels. Its a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.
CSN10240 Aliskiren 173334-57-1 Aliskiren is a renin inhibitor with IC50 of 1.5 nM.
CSN10496 Ambrisentan 177036-94-1 Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).
CSN12096 Tirofiban 144494-65-5 Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIbIIIa receptor used as an antiplatelet drug.
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN12278 Dabigatran 211914-51-1 Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
CSN12447 Fondaparinux Sodium 114870-03-0 Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 40 nM). It can bind to antithrombin III.
CSN16093 Dalcetrapib 211513-37-0 Dalcetrapib is a rhCETP inhibitor with IC50 of 0.2 M.
CSN16692 Eplerenone 107724-20-9 Eplerenone is both a selective aldosterone blocker and a CYP3A4 substrate.
CSN20443 CYM 5541 945128-26-7 CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM.
CSN21155 L-NMMA Acetate 53308-83-1 L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 M, respectively.
CSN21293 Caldaret 133804-44-1 Caldaret is an intracellular Ca2 handling modulator that acts through reverse mode NaCa2 exchanger inhibition.
CSN20029 Esuberaprost Sodium 88475-69-8 Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH).
CSN16953 K-115 223645-67-8 K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension.
CSN18087 Lomitapide Mesylate 202914-84-9 Lomitapide Mesylate is a MTTP inhibitor with IC50 of 8 nM, used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
CSN18616 GAP-134 943134-39-2 GAP-134, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
CSN16542 GAP-134 HCl 943133-81-1 GAP-134 hydrochloride, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
CSN12884 (-)-Sparteine Sulfate Pentahydrate 6160-12-9 (-)-Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker.
CSN20537 MYK-461 1642288-47-8 MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.
CSN22138 J-104132 198279-45-7 J-104132 is a potent, orally active ETAETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells.
CSN22112 Declaben 111149-90-7 Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 M, respectively.
CSN12975 Sitaxsentan 184036-34-8 Sitaxsentan is a selective endothelin A (ETA) receptor antagonist.
CSN12325 Prasugren HCl 389574-19-0 Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 M.
CSN18663 BMS-817378 1174161-69-3 BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
CSN12734 Argatroban 74863-84-6 Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
CSN18579 Zatebradine HCl 91940-87-3 Zatebradine hydrochloride is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner with 92 inhibition of the hHCN1-mediated current at 10 M.
CSN13683 Lomitapide 182431-12-5 Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.
CSN13485 Eltrombopag Olamine 496775-62-3 Eltrombopag olamine is an orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.
CSN12872 Avosentan 290815-26-8 Avosentan is a potent, selective endothelin receptor (ETA receptor) antagonist.
CSN22111 Carbacyclin 69552-46-1 Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
CSN19760 Clazosentan 180384-56-9 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
CSN20026 Esuberaprost 94132-88-4 Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH).
CSN21408 KAI-9803 949100-39-4 KAI-9803 is a potent and selective protein kinase C ( PKC) inhibitor.
CSN22431 Ingliforib 186392-65-4 Ingliforib is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
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