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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16080 | GSK 3 Inhibitor IX | 667463-62-9 | BIO is an inhibitor of GSK-3 and CDK1cyclinB complex. The IC50s of GSK-3, CDK1, CDK5 are 5 nM, 320 nM and 83 nM, respectively. |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN18971 | ONO-7300243 | 638132-34-0 | ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
| CSN12647 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN16171 | Prasugrel | 150322-43-3 | Prasugrel is a platelet inhibitor with IC50 value of 1.8 M. |
| CSN12758 | Cinacalcet hydrochloride | 364782-34-3 | Cinacalcet HCl is an orally active calcimimetic compound and represents a class of compounds for the treatment of hyperparathyroidism. |
| CSN10240 | Aliskiren | 173334-57-1 | Aliskiren is a renin inhibitor with IC50 of 1.5 nM. |
| CSN10332 | Argatroban monohydrate | 141396-28-3 | Argatroban is an inhibitor of thrombin. |
| CSN16825 | Selexipag | 475086-01-2 | NS-304 is an agonist of prostacyclin IP1 receptor with Ki of 260 nM. It is used for the treatment of pulmonary arterial hypertension. |
| CSN10496 | Ambrisentan | 177036-94-1 | Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively). |
| CSN11508 | Nafamostat mesylate | 82956-11-4 | Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity. |
| CSN12923 | Cilostazol | 73963-72-1 | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 M and inhibitor of adenosine uptake. |
| CSN12296 | Eltrombopag | 496775-61-2 | Eltrombopag is an agonist of thrombopoietin-receptor (TpoR) and can stimulate thrombopoiesis. |
| CSN21291 | ML171 | 6631-94-3 | ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 M for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system. |
| CSN10481 | Bosentan (hydrate) | 157212-55-0 | Bosentan is an endothelin (ET) receptor antagonist of ET-A (Ki 4.7 nM) and ET-B (Ki 95 nM). |
| CSN12826 | Ticagrelor | 274693-27-5 | Ticagrelor is a reversibly and oral active P2Y12 receptor antagonist with Ki of 2 nM, also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 M and 8.2 M respectively. |
| CSN11335 | Lovastatin | 75330-75-5 | Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite. |
| CSN12549 | Cinnarizine | 298-57-7 | Cinnarizine, an antihistamine, can block calcium channel and promote cerebral blood flow. It is used to treat post-trauma cerebral symptoms and cerebral arteriosclerosis. |
| CSN12204 | Vinpocetine | 42971-09-5 | Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 M, it also blocks voltage-gated Na channels. Its a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don. |
| CSN12447 | Fondaparinux sodium | 114870-03-0 | Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 40 nM). It can bind to antithrombin III. |
| CSN12096 | Tirofiban | 144494-65-5 | Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIbIIIa receptor used as an antiplatelet drug. |
| CSN12217 | Pirinixic acid | 50892-23-4 | Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN12278 | Dabigatran | 211914-51-1 | Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. |
| CSN16093 | Dalcetrapib | 211513-37-0 | Dalcetrapib is a rhCETP inhibitor with IC50 of 0.2 M. |
| CSN20443 | CYM-5541 | 945128-26-7 | CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM. |
| CSN21155 | L-NMMA acetate | 53308-83-1 | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 M, respectively. |
| CSN21293 | Caldaret | 133804-44-1 | Caldaret is an intracellular Ca2 handling modulator that acts through reverse mode NaCa2 exchanger inhibition. |
| CSN20029 | Esuberaprost Sodium | 88475-69-8 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
| CSN16953 | Ripasudil free base | 223645-67-8 | K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension. |
| CSN10480 | Bosentan | 147536-97-8 | Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
| CSN20537 | Mavacamten | 1642288-47-8 | MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain. |
| CSN22112 | Lodelaben | 111149-90-7 | Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 M, respectively. |
| CSN12975 | Sitaxsentan | 184036-34-8 | Sitaxsentan is a selective endothelin A (ETA) receptor antagonist. |
| CSN12325 | Prasugrel hydrochloride | 389574-19-0 | Prasugrel HCl is a platelet inhibitor with IC50 value of 1.8 μM. |
| CSN18663 | BMS-817378 | 1174161-69-3 | BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model. |
| CSN12734 | Argatroban | 74863-84-6 | Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant. |
| CSN13683 | Lomitapide | 182431-12-5 | Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. |
| CSN13485 | Eltrombopag Olamine | 496775-62-3 | Eltrombopag olamine is an orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. |
| CSN22111 | Carbacyclin | 69552-46-1 | Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. |
| CSN19760 | Clazosentan | 180384-56-9 | Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury. |
| CSN20026 | Esuberaprost | 94132-88-4 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
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