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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16255 | Doxorubicin hydrochloride | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN12283 | β-Lapachone | 4707-32-8 | -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M). |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN12667 | Tivozanib | 475108-18-0 | Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit. |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M). |
| CSN12454 | Vatalanib dihydrochloride | 212141-51-0 | Vatalanib 2HCl is inhibitor of VEGFR2 or KDR with IC50 of 37 nM. |
| CSN16117 | Salirasib | 162520-00-5 | Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki of 2.6 M and can inhibit the methylation of Ras. |
| CSN10852 | Vadimezan | 117570-53-3 | DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. |
| CSN16731 | Daunorubicin hydrochloride | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| CSN12341 | Nintedanib | 656247-17-5 | BIBF 1120 is a multi-RTKs inhibitor with IC50 values of 13nM, 13nM , 16nM , 26nM , 34nM , 37nM , 59nM , 65nM , 69nM , 108nM for VEGFR2, VEGFR3, LCK, FLT3, VEGFR1, FGFR2, PDGFRα, PDGFRβ, FGFR1, FGFR3, less potent to Src, Lyn and FGFR4 with IC50 values of 156nM , 195nM and 610nM, respectively. |
| CSN12236 | Topotecan Hydrochloride | 119413-54-6 | Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN10852 | Vadimezan | 117570-53-3 | DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. |
| CSN13185 | Pomalidomide | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs. |
| CSN15871 | Ondansetron hydrochloride dihydrate | 103639-04-9 | Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist. |
| CSN11403 | Aloin | 1415-73-2 | Aloin A, an anthracycline from aloe plants, can be used as a chemopreventive factor with antineoplastic activity. It exhibits inhibition of phosphodiesterase and tyrosinase. |
| CSN13185 | Pomalidomide | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs. |
| CSN11453 | Mitoxantrone dihydrochloride | 70476-82-3 | Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN12963 | Tipifarnib | 192185-72-1 | Tipifarnib is an inhibitor of farnesyltransferase with IC50 of 0.6 nM. |
| CSN13137 | Ondansetron | 99614-02-5 | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
| CSN16581 | Camptothecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231. |
| CSN16877 | Cabozantinib S-malate | 1140909-48-3 | Cabozantinib S-malate is a VEGFR2 inhibitor with IC50 of 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM-11.3 nM. |
| CSN21898 | Cediranib | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
| CSN17192 | Motesanib Diphosphate | 857876-30-3 | Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET. |
| CSN17586 | Larotrectinib sulfate | 1223405-08-0 | LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC. |
| CSN19151 | BFH772 | 890128-81-1 | BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM. |
| CSN13122 | YO-01027 | 209984-56-5 | Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
| CSN16766 | Idarubicin hydrochloride | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| CSN19726 | Fadrozole hydrochloride | 102676-31-3 | Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively. |
| CSN10166 | Trapidil | 15421-84-8 | Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells. |
| CSN12049 | Teniposide | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN19250 | Miransertib hydrochloride | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
| CSN18065 | Tipifarnib (S enantiomer) | 192185-71-0 | Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
| CSN17839 | 1alpha-Hydroxy VD4 | 143032-85-3 | 1alpha-Hydroxy VD4 , a 1alpha (OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39TSU and P31FUJ cells. |
| CSN10306 | Amsacrine hydrochloride | 54301-15-4 | Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells. |
| CSN16730 | Vatalanib free base | 212141-54-3 | Vatalanib is an inhibitor of VEGFR2KDR with IC50 of 37 nM, showing less potent against VEGFR1Flt-1, 18-fold against VEGFR3Flt-4. |
| CSN17751 | Aldoxorubicin | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN16968 | Larotrectinib | 1223403-58-4 | LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members. |
| CSN16686 | Ondansetron hydrochloride | 99614-01-4 | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN17904 | MC-DOXHZN | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
| CSN18023 | Voreloxin Hydrochloride | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN21384 | Karenitecin | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
| CSN18659 | Lanabecestat | 1383982-64-6 | AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
| CSN10293 | Amonafide | 69408-81-7 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
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