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Cancer

Cat. No. Product Name CAS No. Information
CSN16255 Doxorubicin HCl 25316-40-9 Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
CSN19462 Irinotecan 97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN10824 Dimesna 16208-51-8 Dimesna is a kidney selective prodrug to Mesna.
CSN12283 β-Lapachone 4707-32-8 -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M).
CSN18312 Amsacrine 51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN19463 Irinotecan HCl 100286-90-6 Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN12234 Zebularine 3690-10-6 Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 M.
CSN10852 DMXAA 117570-53-3 DMXAA is an apoptosis inducer with anti-vascular activity. It can inhibit STING and enzyme DT-diaphorase (Ki 20 M).
CSN16731 Daunorubicin HCl 23541-50-6 Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.
CSN12236 Topotecan HCl 119413-54-6 Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
CSN10852 DMXAA 117570-53-3 DMXAA is an apoptosis inducer with anti-vascular activity. It can inhibit STING and enzyme DT-diaphorase (Ki 20 M).
CSN15871 Ondansetron HCl 2H2O 103639-04-9 Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist.
CSN11403 Aloin A 1415-73-2 Aloin A, an anthracycline from aloe plants, can be used as a chemopreventive factor with antineoplastic activity. It exhibits inhibition of phosphodiesterase and tyrosinase.
CSN11119 (+)-Griseofulvin 126-07-8 ()-Griseofulvin is a naturally occuring centrosomal clustering inhibitor and induces keratin cytoskeleton alterations. It is also an antifungal drug.
CSN11453 Mitoxantrone 2HCl 70476-82-3 Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN13137 Ondansetron 99614-02-5 Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231.
CSN21898 Cediranib 288383-20-0 Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN19726 Fadrozole HCl 102676-31-3 Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively.
CSN10166 Trapidil 15421-84-8 Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN16730 Vatalanib 212141-54-3 Vatalanib is an inhibitor of VEGFR2KDR with IC50 of 37 nM, showing less potent against VEGFR1Flt-1, 18-fold against VEGFR3Flt-4.
CSN16686 Ondansetron HCl 99614-01-4 Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
CSN12020 Suramin Sodium 129-46-4 Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 4.9 M), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 M).
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