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Cancer

Cat. No. Product Name CAS No. Information
CSN12283 β-Lapachone 4707-32-8 -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M).
CSN18312 Amsacrine 51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN12667 Tivozanib 475108-18-0 Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit.
CSN16298 Etoposide 33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M).
CSN12454 Vatalanib dihydrochloride 212141-51-0 Vatalanib 2HCl is inhibitor of VEGFR2 or KDR with IC50 of 37 nM.
CSN16117 Salirasib 162520-00-5 Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki of 2.6 M and can inhibit the methylation of Ras.
CSN10852 Vadimezan 117570-53-3 DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells.
CSN12341 Nintedanib 656247-17-5 BIBF 1120 is a multi-RTKs inhibitor with IC50 values of 13nM, 13nM , 16nM , 26nM , 34nM , 37nM , 59nM , 65nM , 69nM , 108nM for VEGFR2, VEGFR3, LCK, FLT3, VEGFR1, FGFR2, PDGFRα, PDGFRβ, FGFR1, FGFR3, less potent to Src, Lyn and FGFR4 with IC50 values of 156nM , 195nM and 610nM, respectively.
CSN10852 Vadimezan 117570-53-3 DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells.
CSN13185 Pomalidomide 19171-19-8 Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs.
CSN15871 Ondansetron hydrochloride dihydrate 103639-04-9 Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist.
CSN11403 Aloin 1415-73-2 Aloin A, an anthracycline from aloe plants, can be used as a chemopreventive factor with antineoplastic activity. It exhibits inhibition of phosphodiesterase and tyrosinase.
CSN13185 Pomalidomide 19171-19-8 Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs.
CSN11453 Mitoxantrone dihydrochloride 70476-82-3 Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN12963 Tipifarnib 192185-72-1 Tipifarnib is an inhibitor of farnesyltransferase with IC50 of 0.6 nM.
CSN13137 Ondansetron 99614-02-5 Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
CSN16877 Cabozantinib S-malate 1140909-48-3 Cabozantinib S-malate is a VEGFR2 inhibitor with IC50 of 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM-11.3 nM.
CSN21898 Cediranib 288383-20-0 Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.
CSN17192 Motesanib Diphosphate 857876-30-3 Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET.
CSN17586 Larotrectinib sulfate 1223405-08-0 LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC.
CSN19151 BFH772 890128-81-1 BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN19726 Fadrozole hydrochloride 102676-31-3 Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively.
CSN10166 Trapidil 15421-84-8 Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN19250 Miransertib hydrochloride 1313883-00-9 ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.
CSN18065 Tipifarnib (S enantiomer) 192185-71-0 Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM.
CSN10306 Amsacrine hydrochloride 54301-15-4 Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.
CSN16730 Vatalanib free base 212141-54-3 Vatalanib is an inhibitor of VEGFR2KDR with IC50 of 37 nM, showing less potent against VEGFR1Flt-1, 18-fold against VEGFR3Flt-4.
CSN17751 Aldoxorubicin 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN16968 Larotrectinib 1223403-58-4 LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.
CSN16686 Ondansetron hydrochloride 99614-01-4 Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin Hydrochloride 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN21384 Karenitecin 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN18659 Lanabecestat 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN10293 Amonafide 69408-81-7 Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
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