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c-RET
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13099 | Regorafenib | 755037-03-7 | Regorafenib is a multi-target inhibitor for VEGFR123, PDGFR, Kit, RET and Raf-1 with IC50 of 134.246 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
| CSN23893 | LOXO-292 | 2222755-14-6 | LOXO-292 is a RET kinase inhibitor with IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively. |
| CSN18365 | AST-487 | 630124-46-8 | AST-487 is a RET kinase inhibitor with IC50 of 880 nM inhibits RET autophosphorylation and activation of downstream effectors also inhibits Flt-3 with IC50 of 520 nM |
| CSN22316 | AD80 | 1384071-99-1 | AD80 is a multikinase inhibitor with inhibitions onRETRAF SRC andS6K |
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