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c-RET
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25546 | Selpercatinib | 2152628-33-4 | Selpercatinib is a potent and specific RET inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively. |
| CSN13099 | Regorafenib | 755037-03-7 | Regorafenib is a multi-target inhibitor for VEGFR123, PDGFR, Kit, RET and Raf-1 with IC50 of 134.246 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
| CSN23893 | LOXO-292 | 2222755-14-6 | LOXO-292 is a selective and potent RET inhibitor and an investigational drug in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase. |
| CSN24470 | GSK3179106 | 1627856-64-7 | GSK3179106 is a potent, selective and gut-restricted RET kinase inhibitor with IC50 value of 0.4nM. |
| CSN22922 | BLU-667 | 2097132-94-8 | Blu667 is a highly potent and selective RET inhibitor with IC50 value of 0.4nM. |
| CSN19120 | BBT594 | 882405-89-2 | BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment. |
| CSN18365 | AST-487 | 630124-46-8 | AST-487 is a RET kinase inhibitor with IC50 of 880 nM inhibits RET autophosphorylation and activation of downstream effectors also inhibits Flt-3 with IC50 of 520 nM |
| CSN22316 | AD80 | 1384071-99-1 | AD80 is a multikinase inhibitor with inhibitions onRETRAF SRC andS6K |
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