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c-Kit
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12411 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN16761 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN17478 | Sitravatinib | 1123837-84-2 | Sitravatinib is an inhibitor of receptor tyrosine kinase (RTK) involved in driving sarcoma cell growth, is developed for the treatment of cancer. |
| CSN18514 | PLX647 | 873786-09-5 | PLX647 is a highly specific dual FMSKIT kinase inhibitor with IC50 of 2816 nM respectively |
| CSN17212 | Pexidartinib | 1029044-16-3 | Pexidartinib is a small-molecule receptor tyrosine kinase RTK inhibitor of KIT CSF1R and FLT3 with IC50s of 20 10 and 160 nM in vitro respectively |
| CSN12340 | Pazopanib | 444731-52-6 | Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively |
| CSN16409 | OSI-930 | 728033-96-3 | OSI-930 is a potent inhibitor of Kit KDR and CSF-1R with IC50 of 80 nM 9 nM and 15 nM respectively and also potent to Flt-1 c-Raf and Lck and low activity against PDGFR Flt-3 and Abl |
| CSN26936 | JNJ-38158471 | 951151-97-6 | JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively . |
| CSN20497 | ISCK03 | 945526-43-2 | ISCK03 is a cell-permeable c-Kit inhibitor with IC50 25 M in cell-free kinase assays and blocks SCF-induced c-kit and Erk phosphorylation 1 M causes 90 inhibition without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells its a phenyl-imidazolosulfonamide compound |
| CSN16807 | Imatinib Mesylate | 220127-57-1 | Imatinib Mesylate is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| CSN11190 | Imatinib | 152459-95-5 | Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M in cell-free or cell-based assays, respectively. |
| CSN11190 | Imatinib | 152459-95-5 | Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M in cell-free or cell-based assays, respectively. |
| CSN12885 | Dovitinib lactate hydrate | 915769-50-5 | Dovitinib lactate is the Lactate of Dovitinib which is a multitargeted RTK inhibitor mostly for class III FLT3c-Kit with IC50 of 1 nM2 nM also potent to class IV FGFR13 and class V VEGFR1-4 RTKs with IC50 of 8-13 nM less potent to InsR EGFR c-Met EphA2 Tie2 IGFR1 and HER2 |
| CSN12808 | Dovitinib lactate | 692737-80-7 | Dovitinib lactate is a potent inhibitor of fibroblast growth factor receptor 3 FGFR3 with an IC50 of 5 nM |
| CSN19493 | Dovitinib | 405169-16-6 | Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM. |
| CSN19172 | Dovitinib Dilactate | 852433-84-2 | Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. |
| CSN22109 | Ripretinib | 1442472-39-0 | DCC-2618 is a pan-KIT and PDGFRA inhibitor and has antitumor activity |
| CSN17587 | c-Kit-IN-1 | 1225278-16-9 | DCC-2618 is a c-Kit and PDGFR inhibitor with IC50s of 63013 nM for c-KitPDGFRPDGFR respectively |
| CSN16497 | Dasatinib | 302962-49-8 | Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| CSN15883 | Agerafenib | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2. |
| CSN15710 | Cabozantinib | 849217-68-1 | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively. |
| CSN20264 | c-KIT/PDGFRα Inhibitor C31 | 2101755-69-3 | c-KITPDGFR inhibitor C31 is a potent selective stem cell factor receptorplatelet derived growth factor receptor alpha c-KITPDGFR dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors GISTs |
| CSN22903 | Avapritinib | 1703793-34-3 | BLU-285 is a potent KIT receptor and PDGFR dual inhibitor with IC50 of 027 and 024 nM for KIT D816V and PDGFR D842V respectively developed as a highly targeted therapy for SM |
| CSN19120 | BBT594 | 882405-89-2 | BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment. |
| CSN10361 | Axitinib | 319460-85-0 | Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively |
| CSN18365 | AST 487 | 630124-46-8 | AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM. |
| CSN16127 | Amuvatinib | 850879-09-3 | Amuvatinib is a potent and multi-targeted inhibitor that inhibits c-Kit, PDGFR and Flt3 with IC50 of 10, 40 and 81 nM respectively. |
| CSN12169 | Tyrphostin AG1296 | 146535-11-7 | AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. It also inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. |
| CSN26939 | HG-7-85-01 | 1258391-13-7 | |
| CSN42653 | N-Desmethyl imatinib mesylate | 404844-03-7 | |
| CSN50397 | N-Desmethyl imatinib | 404844-02-6 |
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