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c-Kit

c-Kit

Cat. No. Product Name CAS No. Information
CSN12411 Sunitinib Malate   341031-54-7 Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN16761 Sunitinib   557795-19-4 Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN17478 Sitravatinib 1123837-84-2 Sitravatinib is an inhibitor of receptor tyrosine kinase (RTK) involved in driving sarcoma cell growth, is developed for the treatment of cancer.
CSN18514 PLX647 873786-09-5 PLX647 is a highly specific dual FMSKIT kinase inhibitor with IC50 of 2816 nM respectively
CSN17212 Pexidartinib   1029044-16-3 Pexidartinib is a small-molecule receptor tyrosine kinase RTK inhibitor of KIT CSF1R and FLT3 with IC50s of 20 10 and 160 nM in vitro respectively
CSN12340 Pazopanib   444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively
CSN16409 OSI-930 728033-96-3 OSI-930 is a potent inhibitor of Kit KDR and CSF-1R with IC50 of 80 nM 9 nM and 15 nM respectively and also potent to Flt-1 c-Raf and Lck and low activity against PDGFR Flt-3 and Abl
CSN26936 JNJ-38158471 951151-97-6 JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively .
CSN20497 ISCK03 945526-43-2 ISCK03 is a cell-permeable c-Kit inhibitor with IC50 25 M in cell-free kinase assays and blocks SCF-induced c-kit and Erk phosphorylation 1 M causes 90 inhibition without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells its a phenyl-imidazolosulfonamide compound
CSN16807 Imatinib Mesylate   220127-57-1 Imatinib Mesylate is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
CSN11190 Imatinib     152459-95-5 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M in cell-free or cell-based assays, respectively.
CSN11190 Imatinib   152459-95-5 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M in cell-free or cell-based assays, respectively.
CSN12885 Dovitinib lactate hydrate 915769-50-5 Dovitinib lactate is the Lactate of Dovitinib which is a multitargeted RTK inhibitor mostly for class III FLT3c-Kit with IC50 of 1 nM2 nM also potent to class IV FGFR13 and class V VEGFR1-4 RTKs with IC50 of 8-13 nM less potent to InsR EGFR c-Met EphA2 Tie2 IGFR1 and HER2
CSN12808 Dovitinib lactate 692737-80-7 Dovitinib lactate is a potent inhibitor of fibroblast growth factor receptor 3 FGFR3 with an IC50 of 5 nM
CSN19493 Dovitinib   405169-16-6 Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM.
CSN19172 Dovitinib Dilactate 852433-84-2 Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
CSN22109 Ripretinib 1442472-39-0 DCC-2618 is a pan-KIT and PDGFRA inhibitor and has antitumor activity
CSN17587 c-Kit-IN-1 1225278-16-9 DCC-2618 is a c-Kit and PDGFR inhibitor with IC50s of 63013 nM for c-KitPDGFRPDGFR respectively
CSN16497 Dasatinib   302962-49-8 Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
CSN15883 Agerafenib 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN15710 Cabozantinib   849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively.
CSN20264 c-KIT/PDGFRα Inhibitor C31 2101755-69-3 c-KITPDGFR inhibitor C31 is a potent selective stem cell factor receptorplatelet derived growth factor receptor alpha c-KITPDGFR dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors GISTs
CSN22903 Avapritinib 1703793-34-3 BLU-285 is a potent KIT receptor and PDGFR dual inhibitor with IC50 of 027 and 024 nM for KIT D816V and PDGFR D842V respectively developed as a highly targeted therapy for SM
CSN19120 BBT594 882405-89-2 BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively
CSN18365 AST 487 630124-46-8 AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
CSN16127 Amuvatinib   850879-09-3 Amuvatinib is a potent and multi-targeted inhibitor that inhibits c-Kit, PDGFR and Flt3 with IC50 of 10, 40 and 81 nM respectively.
CSN12169 Tyrphostin AG1296   146535-11-7 AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. It also inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells.
CSN26939 HG-7-85-01 1258391-13-7
CSN42653 N-Desmethyl imatinib mesylate 404844-03-7
CSN50397 N-Desmethyl imatinib 404844-02-6
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