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c-Kit

c-Kit

Cat. No. Product Name CAS No. Information
CSN17478 Sitravatinib 1123837-84-2 Sitravatinib is an inhibitor of receptor tyrosine kinase (RTK) involved in driving sarcoma cell growth, is developed for the treatment of cancer.
CSN18514 PLX647 873786-09-5 PLX647 is a highly specific dual FMSKIT kinase inhibitor with IC50 of 2816 nM respectively
CSN17212 Pexidartinib     1029044-16-3 Pexidartinib is a small-molecule receptor tyrosine kinase RTK inhibitor of KIT CSF1R and FLT3 with IC50s of 20 10 and 160 nM in vitro respectively
CSN16409 OSI-930 728033-96-3 OSI-930 is a potent inhibitor of Kit KDR and CSF-1R with IC50 of 80 nM 9 nM and 15 nM respectively and also potent to Flt-1 c-Raf and Lck and low activity against PDGFR Flt-3 and Abl
CSN20497 ISCK03 945526-43-2 ISCK03 is a cell-permeable c-Kit inhibitor with IC50 25 M in cell-free kinase assays and blocks SCF-induced c-kit and Erk phosphorylation 1 M causes 90 inhibition without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells its a phenyl-imidazolosulfonamide compound
CSN16807 Imatinib Mesylate   220127-57-1 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M, respectively.
CSN11190 Imatinib     152459-95-5 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 M, 0.1 M and 0.1 M in cell-free or cell-based assays, respectively.
CSN12885 Dovitinib Lactate Hydrate 915769-50-5 Dovitinib lactate is the Lactate of Dovitinib which is a multitargeted RTK inhibitor mostly for class III FLT3c-Kit with IC50 of 1 nM2 nM also potent to class IV FGFR13 and class V VEGFR1-4 RTKs with IC50 of 8-13 nM less potent to InsR EGFR c-Met EphA2 Tie2 IGFR1 and HER2
CSN12808 Dovitinib Lactate 692737-80-7 Dovitinib lactate is a potent inhibitor of fibroblast growth factor receptor 3 FGFR3 with an IC50 of 5 nM
CSN19493 Dovitinib   405169-16-6 Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM.
CSN19172 Dovitinib Dilactate 852433-84-2 Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3c-Kit) with IC50 of 1 nM2 nM, also potent to class IV (FGFR13) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
CSN22109 Ripretinib 1442472-39-0 DCC-2618 is a pan-KIT and PDGFRA inhibitor and has antitumor activity
CSN17587 DCC-2618 1225278-16-9 DCC-2618 is a c-Kit and PDGFR inhibitor with IC50s of 63013 nM for c-KitPDGFRPDGFR respectively
CSN20264 c-KIT/PDGFRα Inhibitor C31 2101755-69-3 c-KITPDGFR inhibitor C31 is a potent selective stem cell factor receptorplatelet derived growth factor receptor alpha c-KITPDGFR dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors GISTs
CSN22903 BLU-285 1703793-34-3 BLU-285 is a potent KIT receptor and PDGFR dual inhibitor with IC50 of 027 and 024 nM for KIT D816V and PDGFR D842V respectively developed as a highly targeted therapy for SM
CSN16127 Amuvatinib   850879-09-3 Amuvatinib is a potent and multi-targeted inhibitor that inhibits c-Kit, PDGFR and Flt3 with IC50 of 10, 40 and 81 nM respectively.
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