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Bromodomain BET/PROTAC

Cat. No. Product Name CAS No. Information
CSN24006 TD-428 N/A TD-428 is a PROTAC targeting on pan-BET with DC50 of 0.32nM for BRD4, consist of BET inhibitor, JQ1, as a warhead linked to CRBN modulator TD-106 as the E3 ligase ligand.
CSN22296 QCA570 2207569-08-0 QCA570 is a potent PROTAC targeting on BET, consist of an optimized BET ligand QCA276 linked to a CRBN E3 ligand.
CSN22195 PROTAC 11 2093386-22-0 PROTAC BET degrader-9 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and Pomalidomide as CRBN ligand.
CSN23933 PROTAC BET degrader-2 2093388-33-9 PROTAC BET degrader-25 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and a Lenalidomide analogue as the CRBN ligand.
CSN21389 BETd-260 2093388-62-4 PROTAC BET Degrader 23 is a highly potent and efficacious PROTAC targeting on BET with DC50 value of 30pM for degradation of BRD4 in RS4;11 leukemia cell line.
CSN21379 MZP-55 2010159-48-3 MZP-55 is a VHL-based PROTAC targeting on BET with pDC50/Dmax (%) values of 8.1/95, 7.5/93, 7.7/92, −/26 for Brd4 short, Brd4 long, Brd3 and Brd2 in HeLa cells, consist of I-BET726 as a warhead ligand linked to VHL ligand VH032.
CSN21378 MZP-54 2010159-47-2 MZP-54 is a PROTAC targeting on BET, consist of a warhead I-BET726 (BET bromodomain inhibitor) linked to a VHL ligand VH032.
CSN22292 MZ1 1797406-69-9 MZ1 is a PROTAC with VHL-ligand and targeting on BRD protein, with preferential selectivity to BRD4 (Kd=149nM) over BRD2 and BRD3.
CSN22289 dBRD9 2170679-45-3 dBRD9 is a potent and selective PROTAC targeting on BRD9, with a PEG-linked pomalidomide
CSN22308 dBET 6 1950634-92-0 dBET6 is an optimized and highly cell-permeable chemical degrader of BET bromodomain proteins, based on PROTAC.
CSN22286 dBET1 1799711-21-9 dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linkerd to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4
CSN21392 AT6 2098836-50-9 AT6 is a PROTAC targeting on Brd4.
CSN21391 AT 1 2098836-45-2 AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM).
CSN18046 ARV-825 1818885-28-7 ARV-825 is a PROTAC targeting on BRD4, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand Pomalidomide, with Kds values of 90nM and 28nM for affinity to BD1 and BD2.
CSN22293 ARV-771 1949837-12-0 ARV-771 is a PROTAC targeting on pan-BET, containing a BRD4-binding moiety (JQ-1) and a VHL-binding moiety.
CSN23919 A1874 2064292-12-0 A1874 is a nutlin-based PROTAC targeting on BRD4, consist of a BRD4-ligand JQ1 linked to a MDM2 E3 ligase ligand RG7388.
CSN24002 PROTAC BET degrader-3 N/A
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