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BMI-1

Cat. No. Product Name CAS No. Information
CSN24787 PTC596 1610964-64-1 PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2].
CSN23234 PTC-028   1782970-28-8 PTC-028 can decrease BMI-1 levels by posttranslational modification
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