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β-catenin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN27594 | β-catenin-IN-2 | 1458664-10-2 | β-catenin-IN-2 is a potent β-catenin inhibitor that can be used for the study of colorectal cancer. |
| CSN17476 | WAY-262611 | 1123231-07-1 | WAY-262611 is an agonist of -Catenin and can increase bone formation rate with EC50 of 063 M |
| CSN19412 | Triptonide | 38647-11-9 | Triptonide, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with antileukemic, antitumor, anti-inflammatory activities, is effective in the treatment of autoimmune diseases. Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. |
| CSN19245 | SKL2001 | 909089-13-0 | SKL2001 is Wnt-catenin pathway agonist which interferes in the interaction of Axin-catenin |
| CSN20164 | PP2A-β-Catenin Inhibitor CS-11 | N/A | PP2A--Catenin inhibitor CS-11 a small molecule inhibitor of PP2A--catenin signaling that limits both in vivo tumor growth and metastasis |
| CSN11650 | Pamidronic acid | 40391-99-9 | Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis. |
| CSN33101 | NRX-103094 | 2763260-36-0 | NRX-103094, a molecular glue, is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. |
| CSN20582 | KY1220 | 292168-79-7 | KY1220 inhibits Wnt-catenin pathway with IC50 of 21 M in HEK293 cells and it can destabilize both -catenin and Ras |
| CSN12696 | ICG001 | 868774-16-7 | ICG-001 is an inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription with IC50 of 3 µM. |
| CSN22363 | C-82 | 1422253-37-9 | C-82 is an active metabolite of PRI-724 which selectively inhibits the CBP-catenin interaction |
| CSN20163 | Tegatrabetan | 1227637-23-1 | beta-Catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma |
| CSN35374 | NRX-252262 | 2438637-61-5 | |
| CSN36240 | 5,7,3',4'-Tetramethoxyflavone | 855-97-0 | |
| CSN42991 | K-756 | 130017-40-2 | |
| CSN62476 | UU-T02 | 1500080-17-0 | |
| CSN66349 | CCT031374 hydrobromide | 1219184-91-4 | |
| CSN69073 | NRX-252114 | 2763260-39-3 | |
| CSN85582 | YW1128 | 2131223-64-6 | |
| CSN51574 | 2-((5-((4-Ethylphenoxy)methyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl)thio)cyclopentanone | 1011440-46-2 |
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