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Bcr-Abl
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25549 | GMB-475 | 2490599-18-1 | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 reduced viability and increased apoptosis in primary CML CD34+ cells, with no effect on healthy CD34+ cells at identical concentrations. |
| CSN16497 | Dasatinib | 302962-49-8 | Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| CSN25318 | AP23848 | 834894-21-2 | AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth. |
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