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Bcl-2

Bcl-2

Cat. No. Product Name CAS No. Information
CSN17851 WEHI-539 1431866-33-9 WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 11 nM
CSN18898 WEHI-539 HCl 2070018-33-4 WEHI-539 HCl is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
CSN22928 VU661013 2131184-57-9 VU661013 is a potent and selective myeloid leukemia cell differentiation protein (MCL-1) inhibitor.
CSN18313 UMI-77 518303-20-3 UMI-77 is a selective Mcl-1 SMI inhibitor binding to the BH3 binding groove of Mcl-1 with Ki of 490 nM
CSN16145 TW-37 877877-35-5 TW-37 is a nonpeptide inhibitor to recombinant Bcl-2 Bcl-xL and Mcl-1 with Ki of 029 M 111 M and 026 M respectively
CSN14606 Thevetiaflavone 29376-68-9 Thevetiaflavone is a natural product isolated and purified from the herbs of Wikstroemia indica.
CSN23122 SMBA 1 906440-37-7 SMBA1 is a selective activator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis.
CSN19228 Sabutoclax 1228108-65-3 Sabutoclax is a pan-Bcl-2 inhibitor including Bcl-xL Bcl-2 Mcl-1 and Bfl-1 with IC50 of 031 M 032 M 020 M and 062 M respectively
CSN19712 S63845 1799633-27-4 S63845 specifically binds with high affinity to the BH3-binding groove of MCL1 S63845 potently kills MCL1-dependent cancer cells including multiple myeloma leukaemia and lymphoma cells by activating the BAXBAK-dependent mitochondrial apoptotic pathway
CSN22926 S55746 1448584-12-0 S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities.
CSN17536 (S)-Gossypol Acetic Acid 1189561-66-7 S-Gossypol acetic acid is an inhibitor of Bcl-2 potently induce cell death in Jurkat cells overexpressing Bcl-2 IC50 181M or Bcl-xL IC50 229M
CSN18897 Pyridoclax 1651890-44-6 Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM
CSN11594 Obatoclax 803712-67-6 Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 MolL), including Mcl-1 (IC50, 2.9 MolL) and Bfl-1 (IC50, 5 MolL).
CSN23774 AML311 315698-17-0 ML311, also known as EU-5346, is a selective inhibitor of the interaction of Mcl-1 and Bim.
CSN18308 MIM1 509102-00-5 MIM1 is a selective small molecule inhibitor of Mcl-1IC50 48 uM that overcomes Mcl-1-dependent leukemia cell survival
CSN21100 MIK 665 1799631-75-6 MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.
CSN22462 Mcl1-IN-4 1580484-04-3 Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 02 M
CSN18186 Mcl1-IN-2 292057-76-2 Mcl1-IN-2 is a Mcl-1 inhibitor without reported IC50 value
CSN18401 Mcl1-IN-1 713492-66-1 Mcl1-IN-1 is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL and demonstrates good Mcl-1 inhibition IC50 24 uM with no appreciable inhibition of Bcl-xL at 100 uM
CSN17591 Marinopyrrole A 1227962-62-0 Marinopyrrole A is a selective Mcl-1 inhibitor with IC50 of 10.1 M and proapoptosis properties in some cancer cells.
CSN13127 Jaceosidin 18085-97-7 Jaceosidin, a methylated trihydroxyflavone, can induce apoptosis in cancer cells via activating Bax and also could block signaling pathways related to inflammation. It is first isolated from the Compositae family.
CSN14611 Isochamaejasmine 93859-63-3 Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S.
CSN11133 HA14-1   65673-63-4 HA14-1 inhibits Bcl-2 with IC50 of 9 M by binding to the surface pocket and disturb the interaction of BaxBcl-2 its cell-permeable
CSN11115 Gossypol Acetate 732279-26-4 Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic.
CSN12617 Gossypol 303-45-7 Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins
CSN13795 Gambogic Acid 2752-65-0 Gambogic acid activates caspases with EC50 of 0.78-1.64 M and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 M, respectively.
CSN22317 FX1   1426138-42-2 FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment by 61-87SMRT and 67-82BCOR 50 M FX1 for 30 min and selectively suppresses BCL6-depenent growth GI50 16-54 M 125 M against BCL6-independent cells in diffuse large B cell lymphoma DLBCL cultures exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain KD 7 MFX1 30 MSMRT 129 M79-6 FX1 shows greater efficacy than 79-6 in reversing BCL6corepressors-mediated target genes repression in vitro IC50 35 M vs 318 M with 79-6 by HEK293T-based reporter assay and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo 100 vs 45 suppression with respective compound via 25 mgkgday ip
CSN20561 CID5721353 301356-95-6 CID5721353 is a B-Cell Lymphoma 6 inhibitor BCL6 inhibitor
CSN23343 BTSA1 314761-14-3 BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity induces conformational changes to BAX leading to BAX-mediated apoptosis
CSN24699 BI-6c9 791835-21-7 BI-6c9 is a Bid inhibitor which prevented MOMP (mitochondrial outer membrane potential) and mitochondrial fission, and protected the cells from cell death.
CSN22193 BI-3812 2166387-64-8 BI-3812 is a BCL6 inhibitor inhibiting the BTB domain of BCL6 with an IC50 of 3 nM
CSN22358 BI-3802 2166387-65-9 BI-3802 is a highly potent BCL6 degrader inhibiting the BTB domain of BCL6 with an IC50 of 3 nM BI-3802 has antitumor activity
CSN18193 BH3I-1   300817-68-9 BH3I-1 is an inhibitor of Bcl-xL with IC50 of 29395 M
CSN18845 BDA-366 1909226-00-1 BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity
CSN18341 Bax Inhibitor Peptide V5 579492-81-2 Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor used for cancer treatment
CSN23786 Bax channel blocker 329349-20-4 Bax channel blocker inhibits Bax-mediated mitochondrial cytochrome c release with IC50 of 0.52 μM.
CSN16589 BAM7   331244-89-4 BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 33 M
CSN23881 BAI1 335165-68-9 BAI1 is an inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).
CSN21099 AZD5991 2143061-81-6 AZD5991 is a potent and selective Mcl-1 inhibitor for treatment of hematologic cancers (a phase I trial of Haematological malignancies).
CSN21081 AZD-4320 1357576-48-7 AZD4320 is a dual inhibitor of BCL-2 and BCL-xl.
CSN18551 AT-101 90141-22-3 AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 M, 0.48 M and 0.18 M.
CSN18501 AT-101 Acetic Acid 866541-93-7 AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 M, 0.48 M and 0.18 M.
CSN13597 Apogossypolone 886578-07-0 Apogossypolone is an inhibitor of Bcl-2 Mcl-1 and Bcl-XL with Ki values of 35nM 25nM and 660nM respectively
CSN20524 AMG-176 1883727-34-1 AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities.
CSN12426 ABT-737 852808-04-9 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL Bcl-2 and Bcl-w with EC50 of 787 nM 303 nM and 1978 nM respectively showing no inhibition observed against Mcl-1 Bcl-B or Bfl-1
CSN12932 ABT-263   923564-51-6 ABT-263 is a potent inhibitor of Bcl-xL Bcl-2 and Bcl-w with Ki ≤ 0.5nM, ≤1 nM and ≤1 nM in cell-free assays.
CSN13680 ABT-199   1257044-40-8 ABT-199 is a Bcl-2-selective inhibitor with Ki of 0.01 nM, 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1.
CSN17604 A-1155463 1235034-55-5 A1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 value of 70 nM in Molt-4 cell
CSN16885 A-1210477 1668553-26-1 A-1210477 is a potent and selective inhibitor of MCL-1 and weakly binds to BCL-2 and BCL-XL with Ki of 045 nM 132 nM and 660 nM respectively
CSN18376 (+)-Apogossypol 66389-74-0 ()-Apogossypol is a potent inhibitor of Bcl-2 family proteins and competes with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 M.
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