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Bcl-2
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18898 | WEHI-539 hydrochloride | 2070018-33-4 | WEHI-539 HCl is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. |
| CSN22928 | VU0661013 | 2131184-57-9 | VU661013 is a potent and selective myeloid leukemia cell differentiation protein (MCL-1) inhibitor. |
| CSN18313 | UMI-77 | 518303-20-3 | UMI-77 is a selective Mcl-1 SMI inhibitor binding to the BH3 binding groove of Mcl-1 with Ki of 490 nM |
| CSN14606 | Thevetiaflavone | 29376-68-9 | Thevetiaflavone is a natural product isolated and purified from the herbs of Wikstroemia indica. |
| CSN23122 | Smba 1 | 906440-37-7 | SMBA1 is a selective activator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis. |
| CSN19228 | Sabutoclax | 1228108-65-3 | Sabutoclax is a pan-Bcl-2 inhibitor including Bcl-xL Bcl-2 Mcl-1 and Bfl-1 with IC50 of 031 M 032 M 020 M and 062 M respectively |
| CSN19712 | S63845 | 1799633-27-4 | S63845 specifically binds with high affinity to the BH3-binding groove of MCL1 S63845 potently kills MCL1-dependent cancer cells including multiple myeloma leukaemia and lymphoma cells by activating the BAXBAK-dependent mitochondrial apoptotic pathway |
| CSN22926 | S55746 | 1448584-12-0 | S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. |
| CSN32507 | S65487 | 1644600-79-2 | S-65487 is a Bcl-2 inhibitor. |
| CSN18897 | Pyridoclax | 1651890-44-6 | Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM |
| CSN11594 | Obatoclax | 803712-67-6 | Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 MolL), including Mcl-1 (IC50, 2.9 MolL) and Bfl-1 (IC50, 5 MolL). |
| CSN23774 | ML311 | 315698-17-0 | ML311, also known as EU-5346, is a selective inhibitor of the interaction of Mcl-1 and Bim. |
| CSN18308 | MIM1 | 509102-00-5 | MIM1 is a selective small molecule inhibitor of Mcl-1IC50 48 uM that overcomes Mcl-1-dependent leukemia cell survival |
| CSN21100 | MIK665 | 1799631-75-6 | MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. |
| CSN22462 | Mcl1-IN-4 | 1580484-04-3 | Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 02 M |
| CSN18401 | Mcl1-IN-1 | 713492-66-1 | Mcl1-IN-1 is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL and demonstrates good Mcl-1 inhibition IC50 24 uM with no appreciable inhibition of Bcl-xL at 100 uM |
| CSN17591 | Maritoclax | 1227962-62-0 | Marinopyrrole A is a selective Mcl-1 inhibitor with IC50 of 10.1 M and proapoptosis properties in some cancer cells. |
| CSN33176 | Lisaftoclax | 2180923-05-9 | Lisaftoclax is a Bcl-2 Inhibitor. |
| CSN13127 | Jaceosidin | 18085-97-7 | Jaceosidin, a methylated trihydroxyflavone, can induce apoptosis in cancer cells via activating Bax and also could block signaling pathways related to inflammation. It is first isolated from the Compositae family. |
| CSN14611 | Isochamaejasmine | 93859-63-3 | Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. |
| CSN11115 | Gossypol xAcetate | 732279-26-4 | Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic. |
| CSN12617 | Gossypol | 303-45-7 | Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins |
| CSN13795 | Gambogic Acid | 2752-65-0 | Gambogic acid activates caspases with EC50 of 0.78-1.64 M and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 M, respectively. |
| CSN22317 | FX1 | 1426138-42-2 | FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment by 61-87SMRT and 67-82BCOR 50 M FX1 for 30 min and selectively suppresses BCL6-depenent growth GI50 16-54 M 125 M against BCL6-independent cells in diffuse large B cell lymphoma DLBCL cultures exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain KD 7 MFX1 30 MSMRT 129 M79-6 FX1 shows greater efficacy than 79-6 in reversing BCL6corepressors-mediated target genes repression in vitro IC50 35 M vs 318 M with 79-6 by HEK293T-based reporter assay and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo 100 vs 45 suppression with respective compound via 25 mgkgday ip |
| CSN20561 | CID5721353 | 301356-95-6 | CID5721353 is a B-Cell Lymphoma 6 inhibitor BCL6 inhibitor |
| CSN23343 | BTSA1 | 314761-14-3 | BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity induces conformational changes to BAX leading to BAX-mediated apoptosis |
| CSN27381 | BT2 | 34576-94-8 | BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. |
| CSN24699 | BI-6C9 | 791835-21-7 | BI-6C9 is a Bid inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from cell death. |
| CSN22193 | BI-3812 | 2166387-64-8 | BI-3812 is a BCL6 inhibitor inhibiting the BTB domain of BCL6 with an IC50 of 3 nM |
| CSN22358 | BI-3802 | 2166387-65-9 | BI-3802 is a highly potent BCL6 degrader inhibiting the BTB domain of BCL6 with an IC50 of 3 nM BI-3802 has antitumor activity |
| CSN18193 | BH3I-1 | 300817-68-9 | BH3I-1 is an inhibitor of Bcl-xL with IC50 of 29395 M |
| CSN27660 | BCL6-IN-7 | 2097518-46-0 | BCL6-IN-7 is a potent BCL6 protein-protein interaction inhibitor with Kd of 78 nM. |
| CSN27291 | BCL6-IN-5 | 2253878-09-8 | BCL6-IN-5 is a potent BCL6 inhibitor exacted from patent WO2018215801A1 with pIC50 of 5.82. |
| CSN18341 | Bax inhibitor peptide V5 | 579492-81-2 | Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor used for cancer treatment |
| CSN23881 | BAI1 | 335165-68-9 | BAI1 is an inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). |
| CSN21099 | AZD-5991 | 2143061-81-6 | AZD5991 is a potent and selective Mcl-1 inhibitor for treatment of hematologic cancers （a phase I trial of Haematological malignancies）. |
| CSN21081 | AZD4320 | 1357576-48-7 | AZD4320 is a dual inhibitor of BCL-2 and BCL-xl. |
| CSN18551 | (R)-(-)-Gossypol | 90141-22-3 | AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 M, 0.48 M and 0.18 M. |
| CSN18501 | (R)-(-)-Gossypol acetic acid | 866541-93-7 | AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 M, 0.48 M and 0.18 M. |
| CSN20524 | Tapotoclax | 1883727-34-1 | AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. |
| CSN13680 | Venetoclax | 1257044-40-8 | ABT-199 is a Bcl-2-selective inhibitor with Ki of 0.01 nM, 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1. |
| CSN18376 | (+)-Apogossypol | 66389-74-0 | ()-Apogossypol is a potent inhibitor of Bcl-2 family proteins and competes with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 M. |
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