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Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN28456 | PROTAC Mcl1 degrader-1 | 2163793-38-0 | PROTAC Mcl1 degrader-1 (compound C3) is a PROTAC targeting on Bcl-2 and Mcl-1 with DC50 values of 3μM and 0.7μM, respectively. |
| CSN28452 | PROTAC Bcl2 degrader-1 | 2378801-85-3 | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC targeting on Bcl-2 and Mcl-1 with DC50 values of 3μM and 0.7μM, respectively. |
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