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Autophagy

Autophagy

Cat. No. Product Name CAS No. Information
CSN11588 Sulfacetamide Sodium   127-56-0 Sulfacetamide sodium is a sulfonamide antibiotic that is used topically to treat skin infections and orally for urinary tract infections
CSN16665 STF-62247   315702-99-9 STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency VHL- compared to wild-type VHL
CSN17766 SR-9011 1379686-29-9 SR9011 is an agonist of REV-ERB with IC50 of 790 nM for REV-ERB and IC50 560 nM for REV-ERB
CSN13809 Spautin-1 1262888-28-7 Spautin-1 is inhibitor of USP10 and USP13 with IC50 of 06 and 07 M respectively its also a potent and specific autophagy inhibitor
CSN23843 Sofalcone 64506-49-6 Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
CSN17302 SMER28 307538-42-7 SMER28 is a small-molecule enhancer SMER of autophagy inducing autophagy independently of the mTOR pathway
CSN18619 SMER18 944153-47-3 SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer
CSN20231 ROC-325 1859141-26-6 ROC-325 is an inhibitor of autophagy with promising anti-leukemic activity which diminishes AML cell viability with the IC50 range of 07-22 M
CSN24043 Metformin 657-24-9 Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN16694 Metformin HCl 1115-70-4 Metformin hydrochloride a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver hepatic gluconeogenesis
CSN22556 Lys05   1391426-24-6 Lys05 is water soluble salt of Lys01 Lys05 shows potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models
CSN22904 IITZ-01   1807988-47-1 IITZ-01 is an inhibitor of lysosomotropic autophagy It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy
CSN11173 Hydroxychloroquine Sulfate   747-36-4 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus rheumatoid arthritis and other autoimmune inflammatory and dermatologic conditions Also acts as an inhibitor of autophagy and toll-like receptor TLR79
CSN16598 Corynoxine 6877-32-3 Corynoxine is an enantiomer of Corynoxine B and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells
CSN18014 Corynoxine B 17391-18-3 Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla Miq Jacks Gouteng in Chinese and a Beclin-1-dependent autophagy inducer
CSN22545 Autophinib   1644443-47-9 Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively
CSN23318 3BDO 890405-51-3
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