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Autophagy
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12203 | Vinorelbine Ditartrate | 125317-39-7 | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. |
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN25367 | Typhaneoside | 104472-68-6 | Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function. |
| CSN11588 | Sulfacetamide Sodium | 127-56-0 | Sulfacetamide sodium is a sulfonamide antibiotic that is used topically to treat skin infections and orally for urinary tract infections |
| CSN16665 | STF-62247 | 315702-99-9 | STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency VHL- compared to wild-type VHL |
| CSN17766 | SR-9011 | 1379686-29-9 | SR9011 is an agonist of REV-ERB with IC50 of 790 nM for REV-ERB and IC50 560 nM for REV-ERB |
| CSN13809 | Spautin-1 | 1262888-28-7 | Spautin-1 is inhibitor of USP10 and USP13 with IC50 of 06 and 07 M respectively its also a potent and specific autophagy inhibitor |
| CSN23843 | Sofalcone | 64506-49-6 | Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
| CSN17302 | SMER28 | 307538-42-7 | SMER28 is a small-molecule enhancer SMER of autophagy inducing autophagy independently of the mTOR pathway |
| CSN18619 | SMER18 | 944153-47-3 | SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer |
| CSN20231 | ROC-325 | 1859141-26-6 | ROC-325 is an inhibitor of autophagy with promising anti-leukemic activity which diminishes AML cell viability with the IC50 range of 07-22 M |
| CSN12058 | Pinosylvin | 22139-77-1 | Pinosylvin, a natural product isolated and purified from the herbs of Pinus yunnanensis, can induce autophagy via AMPK activation. Pinosylvin has anti-inflammatory activity, may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases. |
| CSN24043 | Metformin | 657-24-9 | Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN16694 | Metformin HCl | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN22556 | Lys05 | 1391426-24-6 | Lys05 is water soluble salt of Lys01 Lys05 shows potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models |
| CSN25321 | LC3-mHTT-IN-AN1 | 486443-73-6 | LC3-mHTT-IN-1 is a mHTT-LC3 linker compound, which interacts with mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. |
| CSN22904 | IITZ-01 | 1807988-47-1 | IITZ-01 is an inhibitor of lysosomotropic autophagy It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy |
| CSN11173 | Hydroxychloroquine Sulfate | 747-36-4 | Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus rheumatoid arthritis and other autoimmune inflammatory and dermatologic conditions Also acts as an inhibitor of autophagy and toll-like receptor TLR79 |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN26154 | Fluspirilene | 1841-19-6 | Fluspirilene is a relatively long-acting injectable depot antipsychotic drug. It also works as autophagy inducer that inhibits the intracellular flux of calcium, thus removing the activation factor of calpain. And the cleavage of Atg5 is eventually prevented by fluspirilene treatment in a time-course study. |
| CSN25555 | EACC | 864941-31-1 | EACC inhibits autophagic flux by blocking autophagosome-lysosome fusion. It does not have any effect on lysosomal properties or on endocytosis-mediated degradation of EGF receptor. It affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes. |
| CSN13612 | Dihydroartemisinin | 71939-50-9 | Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities. |
| CSN16598 | Corynoxine | 6877-32-3 | Corynoxine is an enantiomer of Corynoxine B and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells |
| CSN18014 | Corynoxine B | 17391-18-3 | Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla Miq Jacks Gouteng in Chinese and a Beclin-1-dependent autophagy inducer |
| CSN25554 | Chloroquine Sulphate | 132-73-0 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN25650 | Chloroquine | 54-05-7 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN24767 | CA-5f | 1370032-19-1 | CA-5f is identified as a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibted potential clinical application for NSCLC therapy. |
| CSN22545 | Autophinib | 1644443-47-9 | Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively |
| CSN23318 | 3BDO | 890405-51-3 | 3BDO is a new mTOR activator which can also inhibit autophagy. |
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