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Autophagy

Autophagy

Cat. No. Product Name CAS No. Information
CSN25238 UBCS039 358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN25367 Typhaneoside 104472-68-6 Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.
CSN23843 Sofalcone 64506-49-6 Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
CSN12058 Pinosylvin 22139-77-1 Pinosylvin, a natural product isolated and purified from the herbs of Pinus yunnanensis, can induce autophagy via AMPK activation. Pinosylvin has anti-inflammatory activity, may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases.
CSN24043 Metformin 657-24-9 Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN16694 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN25321 LC3-mHTT-IN-AN1 486443-73-6 LC3-mHTT-IN-1 is a mHTT-LC3 linker compound, which interacts with mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
CSN22904 IITZ-01   1807988-47-1 IITZ-01 is an inhibitor of lysosomotropic autophagy It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy
CSN11173 Hydroxychloroquine Sulfate   747-36-4 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus rheumatoid arthritis and other autoimmune inflammatory and dermatologic conditions Also acts as an inhibitor of autophagy and toll-like receptor TLR79
CSN25649 Hydroxychloroquine 118-42-3 Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN13612 Dihydroartemisinin   71939-50-9 Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities.
CSN25554 Chloroquine Sulphate 132-73-0 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25650 Chloroquine 54-05-7 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN22545 Autophinib   1644443-47-9 Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively
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