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Autophagy
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN25367 | Typhaneoside | 104472-68-6 | Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function. |
| CSN23843 | Sofalcone | 64506-49-6 | Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
| CSN12058 | Pinosylvin | 22139-77-1 | Pinosylvin, a natural product isolated and purified from the herbs of Pinus yunnanensis, can induce autophagy via AMPK activation. Pinosylvin has anti-inflammatory activity, may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases. |
| CSN24043 | Metformin | 657-24-9 | Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN16694 | Metformin HCl | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN25321 | LC3-mHTT-IN-AN1 | 486443-73-6 | LC3-mHTT-IN-1 is a mHTT-LC3 linker compound, which interacts with mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. |
| CSN22904 | IITZ-01 | 1807988-47-1 | IITZ-01 is an inhibitor of lysosomotropic autophagy It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy |
| CSN11173 | Hydroxychloroquine Sulfate | 747-36-4 | Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus rheumatoid arthritis and other autoimmune inflammatory and dermatologic conditions Also acts as an inhibitor of autophagy and toll-like receptor TLR79 |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN13612 | Dihydroartemisinin | 71939-50-9 | Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities. |
| CSN25554 | Chloroquine Sulphate | 132-73-0 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN25650 | Chloroquine | 54-05-7 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN22545 | Autophinib | 1644443-47-9 | Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively |
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