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Autophagy

Autophagy

Cat. No. Product Name CAS No. Information
CSN20492 Urolithin A   1143-70-0 Urolithin A is a metabolite of ellagitannin with antiproliferative and antioxidant properties. It can cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease. Urolithin A has been shown to stimulate mitophagy and improve muscle function in aged animals15 and in models of muscular dystrophy,16 while also being safe, bioavailable, and able to induce mitochondrial gene expression in older adults.
CSN25238 UBCS039 358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN25367 Typhaneoside 104472-68-6 Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.
CSN14056 Tephrosin 76-80-2 Tephrosin, a natural product isolated and purified from the herbs of Derris robusta, may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2, and exerts antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells.
CSN16665 4-(Pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine   315702-99-9 STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency VHL- compared to wild-type VHL
CSN13809 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 1262888-28-7 Spautin-1 is inhibitor of USP10 and USP13 with IC50 of 06 and 07 M respectively its also a potent and specific autophagy inhibitor
CSN23843 Sofalcone 64506-49-6 Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
CSN17302 SMER28 307538-42-7 SMER28 is a small-molecule enhancer SMER of autophagy inducing autophagy independently of the mTOR pathway
CSN18619 SMER18 944153-47-3 SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer
CSN20231 ROC-325 1859141-26-6 ROC-325 is an inhibitor of autophagy with promising anti-leukemic activity which diminishes AML cell viability with the IC50 range of 07-22 M
CSN19356 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid   478-43-3 Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling.
CSN22494 QX77 1798331-92-6 QX77 is a chaperone-mediated autophagy (CMA) activator.
CSN11779 (2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-[4,8'-bichromane]-3,3',5,5',7,7'-hexaol 29106-49-8 Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications.
CSN12058 Pinosylvin 22139-77-1 Pinosylvin, a natural product isolated and purified from the herbs of Pinus yunnanensis, can induce autophagy via AMPK activation. Pinosylvin has anti-inflammatory activity, may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases.
CSN12265 PI-103 371935-74-9 PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. It blocks autophagic flux.
CSN16694 1,1-Dimethylbiguanide Hydrochloride   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN22556 Lys05   1391426-24-6 Lys05 is water soluble salt of Lys01 Lys05 shows potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models
CSN11346 LY294002   154447-36-6 LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays. It is an early-stage autophagy inhibitor and also inhibits CK2.
CSN22904 IITZ-01   1807988-47-1 IITZ-01 is an inhibitor of lysosomotropic autophagy It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy
CSN11173 2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol sulfate   747-36-4 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus rheumatoid arthritis and other autoimmune inflammatory and dermatologic conditions Also acts as an inhibitor of autophagy and toll-like receptor TLR79
CSN25649 2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol 118-42-3 Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN29504 Gemcitabine monophosphate 116371-67-6 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN25555 EACC 864941-31-1 EACC inhibits autophagic flux by blocking autophagosome-lysosome fusion. It does not have any effect on lysosomal properties or on endocytosis-mediated degradation of EGF receptor. It affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes.
CSN25554 Chloroquine Sulphate 132-73-0 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25650 N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 54-05-7 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN28416 CA77.1 2412270-22-3 CA77.1 is a brain-penetrant and orally active chaperone-mediated autophagy activator used to treat for Alzheimer's disease.
CSN24767 CA-5f 1370032-19-1 CA-5f is identified as a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibted potential clinical application for NSCLC therapy.
CSN26528 BGT226 915020-55-2 BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
CSN22545 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine   1644443-47-9 Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively
CSN32731 Autogramin-2 2375541-45-8 Autogramin-2 is a new class of autophagy inhibitor with IC50 value of 0.27 ± 0.09 µM (measured by amino acid starvation induced autophagy) and 0.14 ± 0.08 µM (measured by Rapamycin induced autophagy) through targeting GRAMD1A.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
CSN38807 Desethyl chloroquine diphosphate 247912-76-1
CSN41327 Desethyl chloroquine 1476-52-4
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