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Aurora Kinase

Aurora Kinase

Cat. No. Product Name CAS No. Information
CSN12727 ZM447439 331771-20-1 ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM 130 nM respectively 8 fold selectivity than Aurora C MEK1 Src
CSN12326 Tozasertib   639089-54-6 Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively.
CSN23149 TC-A 2317 HCl 1245907-03-2 TC-A2317 HCl is an Aurora kinase A inhibitor.
CSN16128 TAK-901 934541-31-8 TAK-901 is an inhibitor of Aurora AB with IC50 of 21 nM15 nM
CSN18798 SNS-314 Mesylate 1146618-41-8 SNS-314 is a potent and selective inhibitor of Aurora A Aurora B and Aurora C with IC50 of 9 nM 31 nM and 3 nM respectively
CSN13118 SCH-1473759 1094069-99-4 SCH-1473759 is a sub-nanomolar Aurora AB inhibitor with IC50 of 4 nM and 13 nM respectively
CSN17462 SCH-1473759 HCl 1094067-13-6 SCH-1473759 HCl is a sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
CSN15807 Reversine   656820-32-5 Reversine a synthetic purine analogue26-disubstituted purine is a potent human A3 adenosine receptor antagonist with Ki of 066 M and a pan-aurora ABC kinase inhibitor with IC50 of 12 nM13 nM20 nM respectively
CSN12811 PHA-680632 398493-79-3 PHA-680632 is potent inhibitor of Aurora A B and C with IC50 of 27 nM 135 nM and 120 nM respectively
CSN18615 PF-03814735 942487-16-3 PF-03814735 is a potent orally bioavailable reversible small-molecule Aurora kinase inhibitor with IC50 of 08 5 10 and 22 nM for Aurora A Aurora B Flt 1 and FAk respectively
CSN12363 MLN8054 869363-13-3 MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM and exhibits more than 40-fold selective for Aurora A than Aurora B
CSN16817 MK-8745 885325-71-3 MK-8745 is a potent and selective Aurora an inhibitor with IC50 of 06 nM more than 450-fold selectivity for Aurora A over Aurora B
CSN17389 MK-5108 1010085-13-8 MK-5108 is a potent and highly selective Aurora inhibitor with IC50 of 0064 14 and 12 nM for Aurora A B and C
CSN11355 Maleic Acid 110-16-7 Maleic acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. It is a reagent in the preparation of TiO2carbon nanotube composites.
CSN13761 Hesperadin 422513-13-1 Hesperadin is a potent and ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM
CSN12395 GSK1070916 942918-07-2 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora BC with IC50 of 35 nM65 nM and displays 100-fold selectivity against the closely related Aurora A-TPX2 complex IC50490 nM
CSN14824 Derrone 76166-59-1 Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.
CSN24802 DBPR114 N/A DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.
CSN12423 Danusertib 827318-97-8 Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13 79 and 61 nM for Aurora A B and C respectively
CSN17118 CYC-116   693228-63-6 CYC116 is a potent inhibitor of Aurora with Ki of 80 nM92 nM for Aurora AB
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent.
CSN17149 CCT137690 1095382-05-0 CCT137690 is a potent inhibitor of Aurora kinases IC50 values are 0015 0019 and 0025 M at Aurora A Aurora C and Aurora B respectively
CSN16415 CCT129202 942947-93-5 CCT129202 is a Aurora kinase inhibitor with IC50 of 0042 0022 0198 005 and 0227 0064 M for Aurora A Aurora B and Aurora C respectively
CSN16205 BI-847325 1207293-36-4 BI-847325 is a selective and orally bioavailable dual MEKAurora kinase inhibitor with IC50 of 3 nM Xenopus laevis Aurora B 25 nM human Aurora A 15 nM human Aurora C 25 nM human MEK1 and 4 nM human MEK2 respectively
CSN17268 AZD1152-HQPA 722544-51-6 AZD1152-HQPA is the active metabolite of AZD-1152 and a highly selective Aurora B inhibitor with IC50 of 0.37 nM, 100 fold selective for Aurora B over Aurora A.
CSN23770 Aurora Kinase Inhibitor III 879127-16-9 Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase (also designated ARK) inhibitor with IC50 value of 42 nM for Aurora A kinase.
CSN12380 TC-S 7010 1158838-45-9 Aurora an inhibitor I is a potent and selective inhibitor of Aurora A with IC50 of 34 nM in a cell-free assay It is 1000-fold selective for Aurora A than Aurora B
CSN12715 AT9283 896466-04-9 AT9283 is a multi-targeted inhibitor with IC50s of 4 12 11 and approximate 3 nM for Bcr-Abl T315I JAK2 and JAK3 Aurora A and Aurora B respectively
CSN16543 AMG-900 945595-80-2 AMG-900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora ABC with IC50 of 5 nM4 nM 1 nM and is 10-fold selective for Aurora kinases than p38 Tyk2 JNK2 Met and Tie2
CSN13457 Alisertib 1028486-01-2 Alisertib is a selective Aurora inhibitor with IC50 of 12 nM with 200-fold higher selectivity for Aurora A than Aurora B
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