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Aurora Kinase

Aurora Kinase

Cat. No. Product Name CAS No. Information
CSN12727 ZM447439 331771-20-1 ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM 130 nM respectively 8 fold selectivity than Aurora C MEK1 Src
CSN27599 SP-146 N/A SP-146 is a highly selective and non-ATP-competitive Aurora A/B inhibitor with IC50 values of 0.316nM 18.975 nM for Aurora A and Aurora B, respectively.
CSN18798 SNS-314 Mesylate 1146618-41-8 SNS-314 is a potent and selective inhibitor of Aurora A Aurora B and Aurora C with IC50 of 9 nM 31 nM and 3 nM respectively
CSN17462 SCH-1473759 HCl 1094067-13-6 SCH-1473759 HCl is a sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
CSN18615 PF-03814735 942487-16-3 PF-03814735 is a potent orally bioavailable reversible small-molecule Aurora kinase inhibitor with IC50 of 08 5 10 and 22 nM for Aurora A Aurora B Flt 1 and FAk respectively
CSN25344 NU6140 444723-13-1 NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively.
CSN17389 MK-5108 1010085-13-8 MK-5108 is a potent and highly selective Aurora inhibitor with IC50 of 0064 14 and 12 nM for Aurora A B and C
CSN14824 Derrone 76166-59-1 Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.
CSN24802 DBPR114 2443767-35-7 DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.
CSN12423 Danusertib 827318-97-8 Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13 79 and 61 nM for Aurora A B and C respectively
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent.
CSN17149 CCT137690 1095382-05-0 CCT137690 is a potent inhibitor of Aurora kinases IC50 values are 0015 0019 and 0025 M at Aurora A Aurora C and Aurora B respectively
CSN12715 AT9283 896466-04-9 AT9283 is a multi-targeted inhibitor with IC50s of 4 12 11 and approximate 3 nM for Bcr-Abl T315I JAK2 and JAK3 Aurora A and Aurora B respectively
CSN16543 AMG-900 945595-80-2 AMG-900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora ABC with IC50 of 5 nM4 nM 1 nM and is 10-fold selective for Aurora kinases than p38 Tyk2 JNK2 Met and Tie2
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