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ATP Citrate Lyase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN24799 | NDI-091143 | 2375840-87-0 | NDI-091143 is a small-molecule inhibitor of human ACLY. It is located in an allosteric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformational changes in the enzyme that indirectly disrupt citrate binding. |
| CSN12153 | Hydroxycitric Acid | 6205-14-7 | Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects. |
| CSN18618 | BMS-303141 | 943962-47-8 | BMS-303141 is a potent ATPcitrate lyase ACL inhibitor with IC50 of 013 M human recombinant ACL |
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