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ATM/ATR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15802 | VE-822 | 1232416-25-9 | VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells. |
| CSN15863 | VE-821 | 1232410-49-9 | VE-821 is a potent and selective ATP competitive inhibitor of ATR with KiIC50 of 13 nM26 nM |
| CSN17548 | Mirin | 1198097-97-0 | Mirin is a potent Mre11-Rad50-Nbs1 MRN complex inhibitor and inhibits Mre11-associated exonuclease activity |
| CSN15844 | KU-60019 | 925701-46-8 | KU-60019 is an improved analogue of KU-55933 with IC50 of 63 nM for ATM |
| CSN17114 | KU-55933 | 587871-26-9 | KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 22 nM respectively and highly selective for ATM as compared to DNA-PK PI3KPI4K ATR and mTOR |
| CSN17142 | CP-466722 | 1080622-86-1 | CP-466722 a potent and reversible ATM inhibitor does not affect ATR and inhibits PI3K or PIKK family members in cells |
| CSN13686 | Chloroquine Diphosphate | 50-63-5 | Chloroquine Diphosphate is an inhibitor of autophagylysosome and Toll-like receptor TLR signalling also acting as an ATM acitivator its an antimalarial drug |
| CSN16057 | CGK733 | 905973-89-9 | CGK 733 is an inhibitor of ATM and ATR with IC50 of 200 nM also induces cell death in prematurely senescent breast cancer cells |
| CSN20269 | BAY-1895344 | 1876467-74-1 | BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM |
| CSN17205 | AZD6738 | 1352226-88-0 | AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM |
| CSN23317 | AZD1390 | 2089288-03-7 | AZD1390 is an ATM inhibitor with IC50 of 078 nM in cells |
| CSN18824 | AZD0156 | 1821428-35-6 | AZD0156 is a potent and selective inhibitors of ATM kinase with potential chemo-radio-sensitizing and antineoplastic activities |
| CSN22539 | AZ32 | 2288709-96-4 | AZ32 is an ATM inhibitor with IC50 62 nM in enzyme assays and 310 nM in cellular assays |
| CSN22698 | AZ 5704 | 1941214-06-7 | AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM. |
| CSN15890 | AZ 20 | 1233339-22-4 | AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR IC5038 nM |
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