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Apoptosis Inducer
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN21899 | Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | Ubiquitin Isopeptidase Inhibitor I, G5 is an apoptosome-independent caspase and apoptosis activator. |
| CSN13590 | Trabectedin | 114899-77-3 | Trabectedin is an antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo. |
| CSN12434 | Tetrahydrocurcumin | 36062-04-1 | Tetrahydrocurcumin, a natural product isolated and purified from the rhizomes of Curcuma longa L., is one of the major metabolites of Curcumin. It is an apoptosis inducer and has been demonstrated to be an antioxidant. |
| CSN11500 | SMIP004 | 143360-00-3 | SMIP004 is an inducer of cancer-cell selective apoptosis of human prostate cancer cells downregulates SKP2 and stabilizes p27 |
| CSN13728 | Silvestrol | 697235-38-4 | Silvestrol is isolated from the fruits and twigs of Aglaia foveolata by inducing caspase-3 activation to cause cell death |
| CSN18642 | Silvestrol Aglycone | 960365-65-5 | Silvestrol aglycone an aglycone of potential anticancer rocaglate derivative from Aglaia foveolata induces apoptosis in LNCaP cells through the mitochondrialapoptosome pathway without activation of executioner caspase-3 or -7 and a 5myc-UTR-LUC inhibtior IC50 08 nM |
| CSN11911 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| CSN11797 | Pterostilbene | 537-42-8 | Pterostilbene is a natural dietary compound with antioxidant, antiproliferative, antihyperglycemic and antidiabetic effect, and is also an apoptosis inducer. |
| CSN17239 | NSC 348884 | 81624-55-7 | NSC348884 is a nucleophosmin NPM inhibitor inhibits cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 14-4 M |
| CSN18325 | Methyl Protodioscin | 54522-52-0 | Methyl protodioscin is a furostanol bisglycoside with antitumor properties and shows to reduce proliferation, cause cell cycle arrest. It inhibited proliferation and promoted apoptosis of pancreatic cancer. |
| CSN11375 | Meisoindigo | 97207-47-1 | Meisoindigo, a derivative of Indigo naturalis with anticancer activity, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). |
| CSN23859 | Kinetin Riboside | 4338-47-0 | Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM. |
| CSN14103 | Kaurenoic Acid | 6730-83-2 | Kaurenoic Acid is a natural product isolated and purified from the herbs of Croton antisyphiliticus with anti-inflammatory property, the mechanisms may through inhibition of iNOS and COX-2 expression. Kaurenoic acid is an inducer of apoptosis, which is part of the innate mechanism of cell defense against neoplasia. Kaurenoic acid from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans. |
| CSN19280 | Jesridonin | 2074768-37-7 | Jesridonin has synergistic apoptosis-induction effects with paclitaxel mediated by the mitochondrial pathway |
| CSN12309 | Isoalantolactone | 470-17-7 | Isoalantolactone is a naturally occuring sesquiterpene lactone isolated from Inula helenium with a role as an apoptosis inducer an antifungal agent and a plant metabolite |
| CSN18438 | Gynostemma Extract | 80321-63-7 | Gynostemma extract, a natural product isolated and purified from the herb of Gynostemma pentaphyllum (Thunb.) Makino., induces apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade, induces ER stress and production of reactive oxygen species and Ca 2+ , changes the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, and causes cytochrome c release, activation of caspase-3 before leading to apoptosis. |
| CSN18396 | Episilvestrol | 697235-39-5 | Episilvestrol is a derivative of Silvestrol which can induce apoptosis in LNCaP cells through the mitochondrialapoptosome pathway without activation of executioner caspase-3 or -7 and a 5myc-UTR-LUC inhibtor IC50 08 nM |
| CSN16025 | Epibrassinolide | 78821-43-9 | Epibrassinolide is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family, and is shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth. |
| CSN18900 | (E)-[6]-Dehydroparadol | 878006-06-5 | E-6-Dehydroparadol shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 4302 M in HCT-116 cell and 4159 M in H-1299 cell respectively |
| CSN18261 | Desacetylcinobufotalin | 4099-30-3 | Desacetylcinobufotalin is a natural apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 00279 molmL |
| CSN19958 | Columbianadin | 5058-13-9 | Columbianadin, a natural product isolated and purified from the herbs of Angelicae pubescens with analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, can effectively suppress the growth of colon cancer cells, low concentration (up to 25 μM) of CBN induces apoptosis, and high concentration (50 μM) of CBN induces necroptosis, demonstrates that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products. |
| CSN19441 | Cinobufagin | 470-37-1 | Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells. |
| CSN14502 | Cedrelone | 1254-85-9 | Cedrelone, a natural product isolated and purified from the barks of Cedrela toona with antifeedant, antimicrobial, insectidal, and significant cytotoxic activities, is a very potent inducers of apoptosis, it can cause cell cycle arrest. |
| CSN23777 | BTR-1 | 18331-34-5 | BTR-1 is a rhodanine derivative induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, leading to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death. |
| CSN25584 | Atractyloside potassium salt | 102130-43-8 | Atractyloside is a natural compound that acts both an inhibitor of ANT and an apoptosis inducer. |
| CSN12275 | Aromadendrin | 480-20-6 | Aromadendrin, a natural product isolated and purified from the bark of Eucalyptus calophylla, has anti-diabetic, anti-inflammatory, and antioxidant effects. |
| CSN17056 | Apoptosis Activator 2 | 79183-19-0 | Apoptosis activator 2 is a potent apoptosis activator which increases procaspase-9 processing and subsequent caspase-3 activation |
| CSN18300 | Adarotene | 496868-77-0 | Adarotene is an effective apoptosis inducer and surprisingly produced DNA damage ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells |
| CSN10645 | 9-beta-Arabinosylguanine | 38819-10-2 | 9-beta-Arabinosylguanine is an inducer of apoptosis inhibitor of DNA synthesis an antimetabolite and antineoplastic |
| CSN13311 | 3-O-Acetyloleanolic Acid | 4339-72-4 | 3-O-Acetyloleanolic Acid exhibits anti-angiogenic effects and induces apoptosis in HUVECs and HCT-116 cells it is a natural product isolated and purified from the herbs of Phytolacca americana |
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