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Androgen Receptor

Androgen Receptor

Cat. No. Product Name CAS No. Information
CSN12743 RU 58841   154992-24-2 RU 58841 is a nonsteroidal antiandrogen for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth.
CSN19838 RD162 915087-27-3 RD 162 is an orally active and very potent antagonist of androgen receptor AR and is a second-generation of antiandrogen for the treatment of advanced prostate cancer and highly recommended tool in AR research
CSN17663 ORM-15341 1297537-33-7 ORM-15341 is a potent and full antagonist for human AR hAR with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct
CSN17664 Darolutamide 1297538-32-9 ODM-201 is a competitive inhibitor of androgen receptor with IC50 value of 26 nM and inhibits AR nuclear translocation with Ki value of 11 nM.
CSN16774 Nilutamide   63612-50-0 Nilutamide is a non-steroidal androgen receptor antagonist and also inhibits androgen biosynthesis in vitro
CSN17614 N-desmethyl Enzalutamide 1242137-16-1 N-Desmethyl enzalutamide is a major metabolite of Enzalutamide Enzalutamide MDV3100 is an androgen-receptor AR antagonist with IC50 of 36 nM
CSN18667 GSK-2881078 1539314-06-1 GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia
CSN17573 GLPG0492 (R enantiomer) 1215085-93-0 GLPG0492 R-enantiomer is the R-Enantiomer of GLPG-0492 which is a selective androgen receptor modulator
CSN17572 GLPG0492 1215085-92-9 GLPG0492 is a selective androgen receptor modulator and exhibits anabolic activity on muscle strongly dissociated from the androgenic activity on prostate after oral dosing
CSN16707 Flutamide   13311-84-7 Flutamide is a competitive non-steroidal antagonist of androgen receptor.
CSN10468 EPI-001 227947-06-0 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of 6 M and a selective PPAR-gamma modulator
CSN12389 Enzalutamide   915087-33-1 Enzalutamide is an androgen-receptor AR antagonist with IC50 of 36 nM in LNCaP cells
CSN16582 BMS-564929 627530-84-1 BMS-564929 is an androgen receptor AR agonist binds to androgen receptor AR with a Ki of 211016 nM
CSN12437 Bicalutamide   90357-06-5 Bicalutamide is non-steroidal androgen receptor antagonist with IC50 value of 190 nM
CSN17150 AZD3514 1240299-33-5 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 22 M and has ability of reducing AR protein expression
CSN17338 Dimethylcurcumin 52328-98-0 ASC-J9 an antitumor agent suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors
CSN28405 Bavdegalutamide 2222112-77-6 ARV-110 is an orally active, specific androgen receptor PROTAC degrader with DC50 < 1nM.
CSN13830 Apalutamide 956104-40-8 ARN-509 can compeitively and selectively inhibit androgen receptor with IC50 value of 16 nM
CSN28523 ARD-69 2316837-10-0 ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manner. ARD-69 achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, respectively. ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression.
CSN26635 ARCC-4 1973403-00-7 ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC-4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC-4 exemplifies how protein degradation can address the drug resistance hurdles of enzalutamide.
CSN20433 Androgen Receptor Modulator C7 2109805-69-6 Androgen receptor modulator C7 is a potent AR ARE EC50 034 nM and tissue-selective NC interaction EC50 1206 nM modulator
CSN19392 3,3'-Diindolylmethane   1968-05-4 3,3-Diindolylmethane is an AR structurally similar androgen receptor antagonist.
CSN39351 Cyprodinil 121552-61-2
CSN81050 Cyprodinil-13C6 1773496-63-1
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