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Amyloid-β
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13757 | Tramiprosate | 3687-18-1 | Tramiprosate targets soluble A to decrease amyloid plaque deposition and maintains A in a non-fibrillar form. |
| CSN20304 | PE859 | 1402727-29-0 | PE859 is a Curcumin-derived inhibitor of Amyloid- and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8 |
| CSN21321 | MK-3328 | 1201323-97-8 | MK-3328 is a -Amyloid PET ligand which exhibits high binding potency with an IC50 of 105 nM |
| CSN13820 | MK-0752 | 471905-41-6 | MK-0752 is a moderately potent -secretase inhibitor which reduces A40 production with IC50 of 5 nM |
| CSN15566 | Mirabijalone D | 485811-84-5 | Mirabijalone D, a natural product isolated and purified from Abronia nana, is a non-competitive inhibitor based on the Dixon plot, and inhibits A142 production by 43.7 in APPSW-N2a cells. |
| CSN18386 | K 01-162 | 677746-25-7 | K 01-162 binds and destabilizes AO -amyloid with an EC50 of 80 nM |
| CSN23629 | HP-β-CD | 128446-35-5 | HP--CD is used to improve the solubility of lipophilic drugs It is also an inhibitor of amyloid- aggregation and A-induced toxicity |
| CSN19481 | Ginsenoside Rg1 | 22427-39-0 | Ginsenoside Rg1, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey., is a functional ligand of glucocorticoid receptor(GR) that can boost the production of insulin receptors, stimulates the creation of new blood vessels and wound healing, relaxes and widens blood vessels and lowers blood pressure, and is a potent phytoestrogen with estrogen-like activity. |
| CSN11056 | Frentizole | 26130-02-9 | Frentizole, an immunosuppressive drug, is an inhibitor of the A-ABAD interaction. |
| CSN17194 | FPS-ZM1 | 945714-67-0 | FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. |
| CSN11884 | EUK 134 | 81065-76-1 | EUK 134 a synthetic superoxide dismutase SODcatalase mimetic exhibits potent antioxidant activities and inhibits the formation of -amyloid and related amyloid fibril |
| CSN23229 | Edonerpic Maleate | 519187-97-4 | Edonerpic maleate can inhibitamyloid- peptidesA and used as a neurotrophic agent |
| CSN21120 | DWK-1339 | 1018946-38-7 | DWK-1339 is an orally active and blood-brain-barrier-permeable A-aggregation inhibitor used in the research of Alzheimers disease |
| CSN23259 | CRANAD 2 | 1193447-34-5 | CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time. |
| CSN17400 | ARN2966 | 102212-26-0 | ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of A |
| CSN19128 | Amyloid P-IN-1 | 1819986-22-5 | Amyloid P-IN-1 is a potential compound for treating amyloidosis Alzheimers disease type 2 diabetes mellitus and osteoarthritis |
| CSN21167 | Aftin-4 | 866893-90-5 | Aftin-4 is a potent and selective A42 inducer with an EC50 of 30 M |
| CSN21189 | 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine | 566169-98-0 | 4-6-Bromo-2-benzothiazolyl-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid- 1-40 with a KD of 17 nM |
| CSN22036 | 4-(6-Bromo-2-benzothiazolyl)benzenamine | 566169-97-9 | 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome. |
| CSN20235 | 2-D08 | 144707-18-6 | 2-D08 interacts with amyloid β, showing an anti-aggregatory and neuroprotective effect. |
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