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Amyloid-β
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13757 | Tramiprosate | 3687-18-1 | Tramiprosate targets soluble A to decrease amyloid plaque deposition and maintains A in a non-fibrillar form. |
| CSN15667 | Spinosin | 72063-39-9 | Spinosin is a flavone C-glycoside which can be isolated from the seeds of Zizyphus jujuba with anxiolytic-like effects. Spinosin could ameliorate memory impairment induced through Aβ. |
| CSN16909 | Semagacestat | 425386-60-3 | Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM. |
| CSN24621 | Ro 90-7501 | 293762-45-5 | Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly, it can reduce Aβ42-induced toxicity with EC50 of 2 μM. |
| CSN20304 | PE859 | 1402727-29-0 | PE859 is a Curcumin-derived inhibitor of Amyloid- and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8 |
| CSN24622 | NQTrp | 185351-19-3 | NQTrp is an effective inhibitor of Aβ oligomer and fibril formation with IC50 of 50 nM for formation of fibrils from Aβ1-42. |
| CSN21321 | MK-3328 | 1201323-97-8 | MK-3328 is a -Amyloid PET ligand which exhibits high binding potency with an IC50 of 105 nM |
| CSN13820 | MK-0752 | 471905-41-6 | MK-0752 is a moderately potent -secretase inhibitor which reduces A40 production with IC50 of 5 nM |
| CSN24623 | LPYFD-NH2 | 700361-48-4 | LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). It protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. |
| CSN18386 | K 01-162 | 677746-25-7 | K 01-162 binds and destabilizes AO -amyloid with an EC50 of 80 nM |
| CSN26583 | γ-Secretase modulator 4 | 1420200-82-3 | in human and mouse, respectively[1]. |
| CSN23629 | (2-Hydroxypropyl)-β-cyclodextrin | 128446-35-5 | HP--CD is used to improve the solubility of lipophilic drugs It is also an inhibitor of amyloid- aggregation and A-induced toxicity |
| CSN11056 | Frentizole | 26130-02-9 | Frentizole, an immunosuppressive drug, is an inhibitor of the A-ABAD interaction. |
| CSN17194 | FPS-ZM1 | 945714-67-0 | FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. |
| CSN11884 | EUK-134 | 81065-76-1 | EUK 134 a synthetic superoxide dismutase SODcatalase mimetic exhibits potent antioxidant activities and inhibits the formation of -amyloid and related amyloid fibril |
| CSN23229 | Edonerpic maleate | 519187-97-4 | Edonerpic maleate can inhibitamyloid- peptidesA and used as a neurotrophic agent |
| CSN21120 | MDR-1339 | 1018946-38-7 | DWK-1339 is an orally active and blood-brain-barrier-permeable A-aggregation inhibitor used in the research of Alzheimers disease |
| CSN23259 | CRANAD-2 | 1193447-34-5 | CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time. |
| CSN17400 | ARN2966 | 102212-26-0 | ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of A |
| CSN32711 | Valiltramiprosate | 1034190-08-3 | Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents |
| CSN19128 | amyloid P-IN-1 | 1819986-22-5 | Amyloid P-IN-1 is a potential compound for treating amyloidosis Alzheimers disease type 2 diabetes mellitus and osteoarthritis |
| CSN21167 | Aftin-4 | 866893-90-5 | Aftin-4 is a potent and selective A42 inducer with an EC50 of 30 M |
| CSN21189 | 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine | 566169-98-0 | 4-6-Bromo-2-benzothiazolyl-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid- 1-40 with a KD of 17 nM |
| CSN22036 | 4-(6-Bromo-2-benzothiazolyl)benzenamine | 566169-97-9 | 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome. |
| CSN20235 | 2-D08 | 144707-18-6 | 2-D08 interacts with amyloid β, showing an anti-aggregatory and neuroprotective effect. |
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