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Amyloid-β

Amyloid-β

Cat. No. Product Name CAS No. Information
CSN13757 Tramiprosate   3687-18-1 Tramiprosate targets soluble A to decrease amyloid plaque deposition and maintains A in a non-fibrillar form.
CSN24621 Ro 90-7501 293762-45-5 Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly, it can reduce Aβ42-induced toxicity with EC50 of 2 μM.
CSN20304 PE859 1402727-29-0 PE859 is a Curcumin-derived inhibitor of Amyloid- and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8
CSN24622 NQTrp 185351-19-3 NQTrp is an effective inhibitor of Aβ oligomer and fibril formation with IC50 of 50 nM for formation of fibrils from Aβ1-42.
CSN21321 MK-3328 1201323-97-8 MK-3328 is a -Amyloid PET ligand which exhibits high binding potency with an IC50 of 105 nM
CSN13820 MK-0752 471905-41-6 MK-0752 is a moderately potent -secretase inhibitor which reduces A40 production with IC50 of 5 nM
CSN24623 LPYFD-NH2 700361-48-4 LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). It protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo.
CSN18386 K 01-162 677746-25-7 K 01-162 binds and destabilizes AO -amyloid with an EC50 of 80 nM
CSN26583 γ-Secretase modulator 4 1420200-82-3 in human and mouse, respectively[1].
CSN23629 HP-β-CD   128446-35-5 HP--CD is used to improve the solubility of lipophilic drugs It is also an inhibitor of amyloid- aggregation and A-induced toxicity
CSN11056 Frentizole 26130-02-9 Frentizole, an immunosuppressive drug, is an inhibitor of the A-ABAD interaction.
CSN17194 FPS-ZM1   945714-67-0 FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells.
CSN11884 EUK 134 81065-76-1 EUK 134 a synthetic superoxide dismutase SODcatalase mimetic exhibits potent antioxidant activities and inhibits the formation of -amyloid and related amyloid fibril
CSN23229 Edonerpic Maleate 519187-97-4 Edonerpic maleate can inhibitamyloid- peptidesA and used as a neurotrophic agent
CSN21120 DWK-1339 1018946-38-7 DWK-1339 is an orally active and blood-brain-barrier-permeable A-aggregation inhibitor used in the research of Alzheimers disease
CSN23259 CRANAD 2 1193447-34-5 CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
CSN17400 ARN2966 102212-26-0 ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of A
CSN32711 BLU-8499 1034190-08-3 Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents
CSN19128 Amyloid P-IN-1 1819986-22-5 Amyloid P-IN-1 is a potential compound for treating amyloidosis Alzheimers disease type 2 diabetes mellitus and osteoarthritis
CSN21167 Aftin-4 866893-90-5 Aftin-4 is a potent and selective A42 inducer with an EC50 of 30 M
CSN21189 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 4-6-Bromo-2-benzothiazolyl-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid- 1-40 with a KD of 17 nM
CSN22036 4-(6-Bromo-2-benzothiazolyl)benzenamine 566169-97-9 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.
CSN20235 2-D08   144707-18-6 2-D08 interacts with amyloid β, showing an anti-aggregatory and neuroprotective effect.
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