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AMPK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18405 | ZLN024 | 723249-01-2 | ZLN024 is an AMPK allosteric activator and activates 111 and 211 by around 225 fold with an EC50 of about 12 M |
| CSN18969 | ZLN024 hydrochloride | 1883548-91-1 | ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM. |
| CSN17652 | YLF-466D | 1273323-67-3 | YLF-466D is an allosteric AMPK activator |
| CSN17571 | WZ4003 | 1214265-58-3 | WZ4003 is a potent and selective NUAK12 inhibitor with IC50 values of 20 and 100 nM respectively |
| CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN23058 | PT1 | 331002-70-1 | PT 1 is a AMP-activated protein kinase (AMPK) activator. |
| CSN15574 | Phillyrin | 487-41-2 | Phillyrin is a naturally occuring AMPK activity enhancer isolated and purified from the fruits of Forsythia suspensa |
| CSN11690 | Phenformin hydrochloride | 834-28-6 | Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2 |
| CSN22062 | PF-06409577 | 1467057-23-3 | PF-06409577 is a potent and selective allosteric activator of AMPK with EC50 value of 7 nM for AMPK111 but 40000 nM for AMPK121 |
| CSN24788 | O-304 | 1261289-04-6 | O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2]. |
| CSN21095 | EX229 | 1219739-36-2 | Novel AMPK activator increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle |
| CSN13488 | Norathyriol | 3542-72-1 | Norathyriol, a natural product isolated and purified from the herbs of Mangifera indica L., can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation. |
| CSN20469 | MK8722 | 1394371-71-1 | MK-8722 is a potent, direct, allosteric activator of all twelve mammalian AMPK complexes. |
| CSN23901 | MK-3903 | 1219737-12-8 | MK-3903 is a potent and selective AMPK activator with EC50 value of 8nM. |
| CSN16694 | Metformin hydrochloride | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN32438 | Metformin glycinate | 121369-64-0 | Metformin glycinate is an AMPK agonist. |
| CSN26581 | IQZ23 | 2415643-79-5 | IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC50=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders[1]. |
| CSN19218 | GSK621 | 1346607-05-3 | In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation. |
| CSN27189 | IM156 | 1422365-93-2 | IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1. |
| CSN13786 | HTH-01-015 | 1613724-42-7 | HTH-01-015 is a selective NUAK1 inhibitor but not NUAK2 with IC50 of 100 nM suppressing NUAK1-mediated MYPT1 phosphorylation |
| CSN26582 | HL271 | 1422365-52-3 | HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment[1][2]. |
| CSN14375 | Gomisin J | 66280-25-9 | Gomisin J is a natural product isolated and purified from the fruits of Schizandra chinensis with vasodilatory activity that mediates mainly by calcium-dependent activation of eNOS with subsequent production of endothelial NO, and inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox. |
| CSN24159 | Galegine hydrochloride | 2368870-39-5 | Galegine is a toxic chemical compound that has been isolated from Goat's rue. Galegine activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. |
| CSN17240 | Bempedoic acid | 738606-46-7 | ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation. |
| CSN13424 | Dorsomorphin | 866405-64-3 | Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM. |
| CSN15887 | Dorsomorphin dihydrochloride | 1219168-18-9 | Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM. |
| CSN27725 | COH-SR4 | 73439-19-7 | COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes. |
| CSN26107 | ASP4132 | 1640294-30-9 | ASP4132 is a new type of AMPK activator with EC50 value of 18nM. It showed attractive selective growth inhibition against human cancer cells. |
| CSN17597 | Ampkinone | 1233082-79-5 | Ampkinone is a small molecule activator of AMPK and stimulates functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 43 M enhancing glucose uptake by 32-fold |
| CSN23079 | RSVA405 | 140405-36-3 | AMPK activator; also STAT3 inhibitor |
| CSN27358 | Amarogentin | 21018-84-8 | Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK. |
| CSN23366 | Adenosine 5'-monophosphate disodium salt | 4578-31-8 | Adenosine 5-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase AMP deaminase and 5-nucleotidase |
| CSN12424 | A-769662 | 844499-71-4 | A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172 |
| CSN27679 | 7-Methoxyisoflavone | 1621-56-3 | 7-Methoxyisoflavone, an isoflavone derivative, is activator of adenosine monophosphate-activated protein kinase (AMPK). |
| CSN17102 | Danthron | 117-10-2 | 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes. |
| CSN80964 | IMM-H007 | 1221412-23-2 |
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