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AMPK

AMPK

Cat. No. Product Name CAS No. Information
CSN18405 ZLN024 723249-01-2 ZLN024 is an AMPK allosteric activator and activates 111 and 211 by around 225 fold with an EC50 of about 12 M
CSN18969 ZLN024 hydrochloride 1883548-91-1 ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM.
CSN17652 YLF-466D 1273323-67-3 YLF-466D is an allosteric AMPK activator
CSN17571 WZ4003 1214265-58-3 WZ4003 is a potent and selective NUAK12 inhibitor with IC50 values of 20 and 100 nM respectively
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN23058 PT1 331002-70-1 PT 1 is a AMP-activated protein kinase (AMPK) activator.
CSN15574 Phillyrin   487-41-2 Phillyrin is a naturally occuring AMPK activity enhancer isolated and purified from the fruits of Forsythia suspensa
CSN11690 Phenformin hydrochloride   834-28-6 Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2
CSN22062 PF-06409577 1467057-23-3 PF-06409577 is a potent and selective allosteric activator of AMPK with EC50 value of 7 nM for AMPK111 but 40000 nM for AMPK121
CSN24788 O-304 1261289-04-6 O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].
CSN21095 EX229 1219739-36-2 Novel AMPK activator increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle
CSN13488 Norathyriol 3542-72-1 Norathyriol, a natural product isolated and purified from the herbs of Mangifera indica L., can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.
CSN20469 MK8722 1394371-71-1 MK-8722 is a potent, direct, allosteric activator of all twelve mammalian AMPK complexes.
CSN23901 MK-3903 1219737-12-8 MK-3903 is a potent and selective AMPK activator with EC50 value of 8nM.
CSN16694 Metformin hydrochloride   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN32438 Metformin glycinate 121369-64-0 Metformin glycinate is an AMPK agonist.
CSN26581 IQZ23 2415643-79-5 IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC50=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders[1].
CSN19218 GSK621 1346607-05-3 In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation.
CSN27189 IM156 1422365-93-2 IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1.
CSN13786 HTH-01-015 1613724-42-7 HTH-01-015 is a selective NUAK1 inhibitor but not NUAK2 with IC50 of 100 nM suppressing NUAK1-mediated MYPT1 phosphorylation
CSN26582 HL271 1422365-52-3 HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment[1][2].
CSN14375 Gomisin J 66280-25-9 Gomisin J is a natural product isolated and purified from the fruits of Schizandra chinensis with vasodilatory activity that mediates mainly by calcium-dependent activation of eNOS with subsequent production of endothelial NO, and inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox.
CSN24159 Galegine hydrochloride   2368870-39-5 Galegine is a toxic chemical compound that has been isolated from Goat's rue. Galegine activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines.
CSN17240 Bempedoic acid   738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
CSN13424 Dorsomorphin 866405-64-3 Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM.
CSN15887 Dorsomorphin dihydrochloride 1219168-18-9 Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM.
CSN27725 COH-SR4   73439-19-7 COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.
CSN26107 ASP4132 1640294-30-9 ASP4132 is a new type of AMPK activator with EC50 value of 18nM. It showed attractive selective growth inhibition against human cancer cells.
CSN17597 Ampkinone 1233082-79-5 Ampkinone is a small molecule activator of AMPK and stimulates functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 43 M enhancing glucose uptake by 32-fold
CSN23079 RSVA405 140405-36-3 AMPK activator; also STAT3 inhibitor
CSN27358 Amarogentin 21018-84-8 Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
CSN23366 Adenosine 5'-monophosphate disodium salt   4578-31-8 Adenosine 5-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase AMP deaminase and 5-nucleotidase
CSN12424 A-769662 844499-71-4 A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172
CSN27679 7-Methoxyisoflavone 1621-56-3 7-Methoxyisoflavone, an isoflavone derivative, is activator of adenosine monophosphate-activated protein kinase (AMPK).
CSN17102 Danthron 117-10-2 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
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