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AMPK

AMPK

Cat. No. Product Name CAS No. Information
CSN18969 ZLN024 HCl 1883548-91-1 ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM.
CSN17571 WZ4003 1214265-58-3 WZ4003 is a potent and selective NUAK12 inhibitor with IC50 values of 20 and 100 nM respectively
CSN23058 PT 1 331002-70-1 PT 1 is a AMP-activated protein kinase (AMPK) activator.
CSN15574 Phillyrin   487-41-2 Phillyrin is a naturally occuring AMPK activity enhancer isolated and purified from the fruits of Forsythia suspensa
CSN11690 PHenformin HCl   834-28-6 Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2
CSN13488 Norathyriol 3542-72-1 Norathyriol, a natural product isolated and purified from the herbs of Mangifera indica L., can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.
CSN16694 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN19218 GSK621 1346607-05-3 In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation.
CSN14375 Gomisin J 66280-25-9 Gomisin J is a natural product isolated and purified from the fruits of Schizandra chinensis with vasodilatory activity that mediates mainly by calcium-dependent activation of eNOS with subsequent production of endothelial NO, and inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox.
CSN17240 ETC-1002   738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
CSN13424 Dorsomorphin 866405-64-3 Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM.
CSN27725 COH-SR4   73439-19-7 COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.
CSN17597 Ampkinone 1233082-79-5 Ampkinone is a small molecule activator of AMPK and stimulates functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 43 M enhancing glucose uptake by 32-fold
CSN23079 RSVA 405 140405-36-3 AMPK activator; also STAT3 inhibitor
CSN27358 Amarogentin 21018-84-8 Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
CSN23366 Adenosine 5'-monophosphate, disodium salt   4578-31-8 Adenosine 5-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase AMP deaminase and 5-nucleotidase
CSN12424 A-769662 844499-71-4 A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172
CSN17102 1,8-Dihydroxyanthraquinone 117-10-2 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
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