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Alkaloids

Alkaloids

Cat. No. Product Name CAS No. Information
CSN14756 Zanthobungeanine 64190-94-9 Zanthobungeanine, a natural product isolated and purified from the roots of Zanthoxylum nitidum with anti-inflammatory activity, shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell, moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L, and obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF).
CSN12193 Vasicine 6159-55-3 Vasicine, a natural product isolated and purified from the leaves of Adhatoda vasica, is a potential cholinesterase inhibitor in development for treatment of Alzheimers disease, and can regulate the inflammatory reaction.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-B.
CSN14159 Strictosamide 23141-25-5 Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
CSN11976 Stachydrine HCl   4136-37-2 Stachydrine HCl is a naturally occuring anti-metastatic agent iin vitroi which is isolated from seed husk and the pulp of the fruit of C. Leonurus.
CSN17136 Sophocarpine Hydrate 145572-44-7 Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK.
CSN17136 Sophocarpine Hydrate 145572-44-7 Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK.
CSN15659 Skimmianin 83-95-4 Skimmianin, a natural product isolated and purified from the herbs of Skimmia japonica, is an inhibitor against the Leishmania APRT enzyme and a strong acetylcholinesterase (AChE) inhibitor, and has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats.
CSN15659 Skimmianin 83-95-4 Skimmianin, a natural product isolated and purified from the herbs of Skimmia japonica, is an inhibitor against the Leishmania APRT enzyme and a strong acetylcholinesterase (AChE) inhibitor, and has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN15000 Sambutoxin 160047-56-3 Sambutoxin, a natural product isolated and purified from the rotted potato tubers, can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin.
CSN12999 Rocaglamide 84573-16-0 Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.
CSN20358 Pseudouridimycin 1566586-52-4 Pseudouridimycin is a natural product that potently and selectively inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture, and clears infection in a mouse model of Streptococcus pyogenes peritonitis.
CSN12413 Piperine   94-62-2 Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects.
CSN14002 Pellitorine 18836-52-7 Pellitorine, a natural product isolated and purified from the herbs of Anacyclus pyrethrum, shows cytotoxic, antiprotozoal and potent antiplatelet aggregation activities against HL60 and MCF-7 cell lines.
CSN11639 Oxysophoridine 54809-74-4 Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L.
CSN15263 Norcepharadione B 57576-41-7 Norcepharadione B, a natural product isolated and purified from the herbs of Houttuynia cordata Thunb. with good inhibitory activity against the replication of HSV-1, exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
CSN14542 Neoechinulin A 51551-29-2 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
CSN14183 N-Nornuciferine 4846-19-9 N-Nornuciferine, a natural product isolated and purified from the fruits of Piper nigrum, can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM.
CSN14564 Macusine B 6792-07-0 Macusine B is a natural product isolated and purified from the herbs of Rauvolfia verticillata and a dual inhibitor with almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
CSN14200 Macamide B 74058-71-2 Macamide B is a natural product isolated and purified from the herbs of Lepidium meyenii Walp.
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN14552 Laurifoline 7224-61-5 Laurifoline, a natural product isolated and purified from the herbs of Lindera aggregata, is a potential NF-B inhibitor and a potential 2 -adrenegic receptor agonist. It can not only inhibit Pseudomonas aeruginosa PAK strain-induced inflammatory responses via a negative regulation of the Braf protein that participates in MAPK signaling pathway but also activate the 2 -adrenegic receptor.
CSN23591 Indole-3-carboxylic acid   771-50-6 Indole-3-carboxylic Acid is a normal urinary indolic tryptophan metabolite with multiple biological roles such as serotonin 5-HT46 receptor antagonist, EphB3 receptor tyrosine kinase inhibitor, vinyl ester pseudotripeptide proteasome inhibitor and potential therapeutic agent for Alzheimers Disease.
CSN14540 Gelsevirine 38990-03-3 Gelsevirine, a natural product isolated and purified from the herbs of Gelsemium elegans with anxiolytic activity, may be via the agonist action of glycine receptor in the brain, and can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively.
CSN10697 Gelsemine 509-15-9 Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.
CSN13548 Evocarpine 15266-38-3 Evocarpine has an antimycobacterial activity on antagonistic effects of indoloquinazoline alkaloids.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN14557 Enniatin B1 19914-20-6 Enniatin B1, a natural product isolated and purified from Fusarium avenaceum, with intestinal toxicity and antifungal effects, induces apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.
CSN14190 Dihydroevocarpine 15266-35-0 Dihydroevocarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa, is a moderate modulator of p-glycoprotein (p-gp) activity. Dihydroevocarpine also shows more potent inhibitory effects against MAO-B compared to MAO-A and potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 mgmL.
CSN13532 Dihydroberberine 483-15-8 Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.
CSN19952 Dendrobine 2115-91-5 Dendrobine, a natural product isolated and purified from the herb of Dendrobium nobile Lindl., is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord, has antitumor activity,can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway, and possesses antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 ± 0.32, 2.16 ± 0.91, 5.32 ± 1.68 ug/mL, respectively.
CSN15643 Demethoxyfumitremorgin C 111768-16-2 Demethoxyfumitremorgin C, a natural metabolite isolated and purified from marine fungus Aspergillus fumigatus, inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death, and could therefore serve as a useful agent to treat human advanced prostate cancer.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN15639 D-Tetrahydropalmatine 3520-14-7 D-Tetrahydropalmatine, a natural product isolated and purified from the barks of Phellodendron chinense Schneid, is an organic cation transporter 1 (OCT1) inhibitor, and obviously inhibits the uptake of MCT in MDCK-hOCT1 cells and isolated rat primary hepatocytes, and attenuates the viability reduction and LDH release of the primary cultured rat hepatocytes caused by MCT.
CSN18820 Crotonoside 1818-71-9 Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats.
CSN14149 Crebanine 25127-29-1 Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs.
CSN18353 Coptisine Chloride   6020-18-4 Coptisine Chloride is a naturally occuring cytotoxic alkaloid found in Chinese goldthread which shows cytotoxic effect on heptoma and leukemic cells and is reported to block cell cycle progression.
CSN10155 Coixol 532-91-2 Coixol is a natural product isolated and purifed from the seeds of Coix lacryma-jobi L.
CSN14993 Axillaridine A 128255-16-3 Axillaridine A, a natural cholinesterase inhibitor isolated and purified from the herbs of Pachysandra axillaris, may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimers disease patients by potentiating and effecting the cholinergic transmission process.
CSN14746 Akuammigine 642-17-1 Akuammidine, a natural product isolated and purified from the herbs of Picralima nitida with in vitro antimalarial activity, shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 mM at mu-, delta- and kappa-opioid binding sites, respectively and the agonist actions of akuammidine in the mouse-isolated vas deferens were antagonised by naloxone and the mu-opioid receptor selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) confirming an action at mu-opioid receptors, and competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68.
CSN18309 Aconine 509-20-6 Aconine is a natural product.
CSN14545 5-Hydroxy-4-Methoxycanthin-6-One 18110-86-6 5-Hydroxy-4-methoxycanthin-6-one, a natural product isolated and purified from the barks of Picrasma quassioides (D.Don) Benn with anti-inflammatory effect and protective effect on dextran sulfate sodium -induced rat colitis, exhibits significant cytotoxic activity against CNE2 cell line, reduces the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
CSN15644 14-Norpseurotin A 1031727-34-0 14-Norpseurotin A is a natural product isolated and purified from the cultures of Aspergillus fumigatus, shows good antileishmanial and moderate anticancer activities, significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration, and displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 mM , respectively.
CSN14152 1-Hydroxyrutaecarpine 53600-24-1 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL.
CSN14992 (Z)-Akuammidine 113973-31-2 (Z)-Akuammidine is a potent -opioid agonist isolated and purified from the roots of Gelsemium elegans.
CSN14755 (-)-Corlumine 79082-64-7 (-)-Corlumine is a natural product isolated and purified from the herbs of Fumaria parviflora with spasmolytic and GABA antagonist activity.
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