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Alkaloids

Alkaloids

Cat. No. Product Name CAS No. Information
CSN12207 Vitamin B1   59-43-8 Vitamin B1 is a water-soluble vitamin, as are all vitamins of the B complex.
CSN12193 Vasicine 6159-55-3 Vasicine, a natural product isolated and purified from the leaves of Adhatoda vasica, is a potential cholinesterase inhibitor in development for treatment of Alzheimers disease, and can regulate the inflammatory reaction.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-B.
CSN19348 Theobromine 83-67-0 Theobromine, a xanthine alkaloid isolated and purified from the fruits of Theobroma cacao L., is widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.
CSN11976 Stachydrine HCl   4136-37-2 Stachydrine HCl is a naturally occuring anti-metastatic agent iin vitroi which is isolated from seed husk and the pulp of the fruit of C. Leonurus.
CSN18090 Solamargine     20311-51-7 Solamargine is a naturally-occuring glycoalkaloid isolated from plants of the Solanaceae family which has been used in trials studying the treatment of Actinic Keratosis.
CSN16625 Sanguinarine 2447-54-3 Sanguinarine is a benzophenanthridine alkaloid which has anti-microbial, anti-oxidant and anti-inflammatory properties. It is a specific inhibitor of Rac1b, and with potential antitumor activity.
CSN16137 Quinine   130-95-0 Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree.
CSN19448 Protopine   130-86-9 Protopine is a naturally occuring benzylisoquinoline alkaloid found in plants of the family papaveraceae It acts as an analgesic and can inhibit histamine H1 receptors
CSN12413 Piperine   94-62-2 Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects.
CSN15263 Norcepharadione B 57576-41-7 Norcepharadione B, a natural product isolated and purified from the herbs of Houttuynia cordata Thunb. with good inhibitory activity against the replication of HSV-1, exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
CSN14183 N-Nornuciferine 4846-19-9 N-Nornuciferine, a natural product isolated and purified from the fruits of Piper nigrum, can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM.
CSN14564 Macusine B 6792-07-0 Macusine B is a natural product isolated and purified from the herbs of Rauvolfia verticillata and a dual inhibitor with almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
CSN14200 Macamide B 74058-71-2 Macamide B is a natural product isolated and purified from the herbs of Lepidium meyenii Walp.
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN14552 Laurifoline 7224-61-5 Laurifoline, a natural product isolated and purified from the herbs of Lindera aggregata, is a potential NF-B inhibitor and a potential 2 -adrenegic receptor agonist. It can not only inhibit Pseudomonas aeruginosa PAK strain-induced inflammatory responses via a negative regulation of the Braf protein that participates in MAPK signaling pathway but also activate the 2 -adrenegic receptor.
CSN11233 Isotetrandrine 477-57-6 Isotetrandrine, a natural product isolated and purified from the roots of Stephania tetrandra S.Moore, dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-B, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
CSN19987 Isofangchinoline   33889-68-8 Isofangchinoline is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra, which may be an inactivator of nuclear NR4A1, as well as inhibited cell proliferation and induced apoptosis in human pancreatic cancer cells.
CSN23591 Indole-3-carboxylic acid   771-50-6 Indole-3-carboxylic Acid is a normal urinary indolic tryptophan metabolite with multiple biological roles such as serotonin 5-HT46 receptor antagonist, EphB3 receptor tyrosine kinase inhibitor, vinyl ester pseudotripeptide proteasome inhibitor and potential therapeutic agent for Alzheimers Disease.
CSN19447 Harringtonine 26833-85-2 Harringtonine is a natural alkaloid isolated and purified from the branch of Cephalotaxus fortunei Hook.f., and an anticancer drug with high chemotherapeutic efficiency to human chronic granulocyticmyelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scoperange of dosage by investigators from our lab and others. Harringtonine exerts its antiviral effects by inhibiting Chikungunya virus (CHIKV) viral protein synthesis.
CSN10697 Gelsemine 509-15-9 Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.
CSN10207 Flaconitine 77181-26-1 Flaconitine is an alkaloid isolated from Aconitum flavum.
CSN13548 Evocarpine 15266-38-3 Evocarpine has an antimycobacterial activity on antagonistic effects of indoloquinazoline alkaloids.
CSN14557 Enniatin B1 19914-20-6 Enniatin B1, a natural product isolated and purified from Fusarium avenaceum, with intestinal toxicity and antifungal effects, induces apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.
CSN14176 Enniatin B 917-13-5 Enniatin B, a natural product isolated and purified from the Pencillium urticae with anticancer and antiangiogenic properties, can decrease Monocytes endocytosis ability and an increase of CD71.
CSN14190 Dihydroevocarpine 15266-35-0 Dihydroevocarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa, is a moderate modulator of p-glycoprotein (p-gp) activity. Dihydroevocarpine also shows more potent inhibitory effects against MAO-B compared to MAO-A and potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 mgmL.
CSN13532 Dihydroberberine 483-15-8 Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.
CSN14038 Deoxyvasicinone 530-53-0 Deoxyvasicinone, a natural product isolated and purified from the herbs of Galium aparine L., can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.
CSN12661 Dehydroevodiamine   67909-49-3 Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.
CSN14154 Dehydrocrenatidine 65236-62-6 Dehydrocrenatidine, a natural product isolated and purified from the barks of Picrasma quassioides, is a JAK-specific inhibitor, which inhibits JAK2-JH1 kinase activity in vitro , represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon--, and interferon--stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression.
CSN15639 D-Tetrahydropalmatine 3520-14-7 D-Tetrahydropalmatine, a natural product isolated and purified from the barks of Phellodendron chinense Schneid, is an organic cation transporter 1 (OCT1) inhibitor, and obviously inhibits the uptake of MCT in MDCK-hOCT1 cells and isolated rat primary hepatocytes, and attenuates the viability reduction and LDH release of the primary cultured rat hepatocytes caused by MCT.
CSN18820 Crotonoside 1818-71-9 Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats.
CSN18353 Coptisine Chloride   6020-18-4 Coptisine Chloride is a naturally occuring cytotoxic alkaloid found in Chinese goldthread which shows cytotoxic effect on heptoma and leukemic cells and is reported to block cell cycle progression.
CSN19471 Cepharanthine   481-49-2 Cepharanthine is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It possesses potency of antiinflammatory, antineoplastic and effect against HTLV.
CSN14179 Caulilexin C 30536-48-2 Caulilexin C is a natural product isolated and purified from the herbs of Isatis idigotica, showing inhibitory activity on human Acyl CoA cholesterol transferase I (hACATI) and on human Acyl CoA cholesterol transferase 2 (hACAT2) at 100 ugmL.
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231.
CSN14165 Calyxamine B 150710-72-8 Calyxamine B is a natural product isolated and purified from the herbs of Salsola tetrandra, has inhibitory activity on acetylcholinesterase, the effect is comparable to the natural inhibitors.
CSN14993 Axillaridine A 128255-16-3 Axillaridine A, a natural cholinesterase inhibitor isolated and purified from the herbs of Pachysandra axillaris, may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimers disease patients by potentiating and effecting the cholinergic transmission process.
CSN18309 Aconine 509-20-6 Aconine is a natural product.
CSN13080 9-Aminocamptothecin   91421-43-1 9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.
CSN14992 (Z)-Akuammidine 113973-31-2 (Z)-Akuammidine is a potent -opioid agonist isolated and purified from the roots of Gelsemium elegans.
CSN13176 (-)-Isocorypalmine 483-34-1 (-)-Isocorypalmine, a natural product isolated and purified from the tubers of Corydalis yanhusuo W. T. Wang, with significant antifungal activity, also acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.
CSN14755 (-)-Corlumine 79082-64-7 (-)-Corlumine is a natural product isolated and purified from the herbs of Fumaria parviflora with spasmolytic and GABA antagonist activity.
CSN17136 Sophocarpine Hydrate 145572-44-7
CSN15659 Skimmianin 83-95-4
CSN15660 Daurisoline 70553-76-3
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