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ALK

ALK

Cat. No. Product Name CAS No. Information
CSN20579 TPX-0005 1802220-02-5 TPX-0005 is a potent ALKROS1TRK inhibitor with IC50 of 53 nM 101 nM 126 nM and 108 nM for SRC WT ALK ALK G1202R and ALK L1196M respectively
CSN22607 TP0427736 HCl   N/A TP0427736 HCl is the hydrochloride form of TP0427736 which is an inhibitor of ALK5 with IC50 of 272 nM and can reduce TGF- induced growth
CSN22508 SM 16 614749-78-9 SM 16 is an an ATP-competitive ALK5ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-1-induced Smad23 phosphorylation in cell study.
CSN15922 PF-06463922 1454846-35-5 PF-06463922 is an orally available, CNS-penetrant, ATP-competitive inhibitor of ALKROS1 with Ki of 0.02 nM, 0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
CSN12422 NVP-TAE 684 761439-42-3 NVP-TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM in a cell-free assay 100-fold more sensitive for ALK than InsR
CSN16207 LDK378 2HCl   1380575-43-8 LDK378 2HCl is a selective ALK inhibitor with an IC50 of 02 nM and also inhibits InsR IGF-1R STK22D FLT3 and FGFR2 with IC50 values of 7 nM 8 nM 23 nM 60 nM and 260 nM
CSN21367 JH-VIII-157-02 1639422-97-1 JH-VIII-157-02 is a structural analogue of alectinib acts as an ALK inhibitor and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK EML4-ALK G1202R in cells
CSN17746 HG-14-10-04 1356962-34-9 HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM
CSN17470 Entrectinib   1108743-60-7 Entrectinib is an oral pan-Trk, ROS1, and ALK inhibitor, with IC50 of 1.70.10.1 nM, 0.2 nM, and 1.6 nM for Trk ABC, ROS1, and ALK, respectively.
CSN18668 Ensartinib 1365267-27-1 Ensartinib is a potent inhibitor ofALK, which is used to treat non-small-cell lung cancer.
CSN22549 Ensartinib 1370651-20-9 Ensartinib is a novel potent anaplastic lymphoma kinase ALK small molecule tyrosine kinase inhibitor TKI with additional activity against MET ABL Axl EPHA2 LTK ROS1 and SLK ALK autophosphorylation is significantly diminished by X-396 albeit at higher concentrations required to block autophosphorylation of the wild-type fusion
CSN12319 Crizotinib     877399-52-5 Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
CSN13803 Crizotinib HCl 1415560-69-8 Crizotinib hydrochloride is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM respectivley
CSN15842 CH5424802 HCl 1256589-74-8 CH5424802 hydrochloride is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
CSN15775 Ceritinib   1032900-25-6 Ceritinib is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
CSN19158 CEP-28122 Mesylate 1431697-88-9 CEP-28122 mesylate is a highly potent and selective orally active ALK inhibitor with IC50 of 19 05 nM in an enzyme-based TRF assay
CSN16925 CEP-28122 1022958-60-6 CEP-28122 is a highly potent and selective orally active ALK inhibitor with IC50 of 19 05 nM in an enzyme-based TRF assay
CSN17547 Brigatinib 1197953-54-0 Brigatinib is a selective ALK inhibitor with IC50 value of 037nM and also inhibits ROS1 FLT3 FLT3-D835Y mutant and EGFR less potently
CSN22546 Belizatinib 1357920-84-3 Belizatinib is a selective ALK inhibitor with IC50 value of 07nM as well as shows potency against TRK A B and C with IC50 values3nM
CSN15910 AZD3463 1356962-20-3 AZD3463 is an orally bioavailable ALK inhibitor with Ki of 075 nM which also inhibits IGF1R with equivalent potency
CSN17127 ASP3026 1097917-15-1 ASP3026 is a selective inhibitor for ALK with IC50 of 35 nM
CSN16870 ALK-IN-1 1197958-12-5 AP26113 is an analog of AP26113 which is a potent and selective ALK inhibitor It is also an inhibitor of EGFR
CSN19724 ALK Inhibitor C29 2093414-37-8 ALK inhibitor C29 shows promising anti-ALK activities in enzymatic- and cell-based assays while in vivo H3122 xenograft model study showed that it effectively suppressed ALK-driven tumor growth
CSN18423 ALK Inhibitor 2 761438-38-4 ALK inhibitor 2 is a selective inhibitor for the ALK kinase
CSN18422 ALK Inhibitor 1 761436-81-1 ALK inhibitor 1 is a selective inhibitor for the ALK kinase
CSN13474 Alectinib     1256580-46-7 Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM while also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s 1.0, 3.5, and 1.6 nM, respectively).
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