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ALK/PROTAC

Cat. No. Product Name CAS No. Information
CSN22281 TL13-12 2229037-04-9 TL13-12 is PROTAC selectively targeting on ALK with DC50 values of 10nM and 180nM in H3122 and Karpas 299 cells, respectively, consist of an ALK-binding TAE684 ligand linked to Pomalidomide.
CSN22280 TL13-112 2229037-19-6 TL13-112 is PROTAC selectively targeting on ALK with DC50 values of 10nM and 40nM in H3122 and Karpas 299 cells, respectively, consist of an ALK-binding LDK378 ligand linked to Pomalidomide.
CSN22283 MS4078 2229036-62-6 MS4078 is a PROTAC targeting on ALK with DC50 value of 11nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide.
CSN22282 MS4077 2230077-10-6 MS4077 is a PROTAC targeting on ALK with DC50 value of 3nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide.
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