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Aldose Reductase

Aldose Reductase

Cat. No. Product Name CAS No. Information
CSN12110 Tolrestat 82964-04-3 Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 value of 35 nM.
CSN17888 Ranirestat 147254-64-6 Ranirestat is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy
CSN16506 Isoliquiritigenin   961-29-5 Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound.
CSN21685 IMIRESTAT 89391-50-4 Imirestat is an inhibitor of aldose reductase which is used for the treatment of diabetes.
CSN22130 Fidarestat 136087-85-9 Fidarestat is an inhibitor of aldose reductase with IC50s of 26 nM 33 M and 18 M for aldose reductase AKR1B10 and V301L AKR1B10 respectively Fidarestat has the potential to treat diabetic disease
CSN12976 Epalrestat 82159-09-9 Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.
CSN13622 EBPC 4450-98-0 EBPC is a potent aldose reductase inhibitor which inhibits PGF2α production, enhances ERK activity and potentiates anticancer effects of cisplatin and doxorubicin.
CSN14844 Dehydroglyasperin D 517885-72-2 Dehydroglyasperin D, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with anti-obesity, antioxidant, anti-aldose reductase, anticancer, anti-inflammator and strong ferric reducing activities, inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase, mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3, effectively scavenges DPPH, ABTS(+), and singlet oxygen radicals.
CSN15661 Byacangelicin 482-25-7 Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
CSN25218 AT-007 2170729-29-8 AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia.
CSN18314 Alrestatin Sodium 51876-97-2 Alrestatin sodium is an inhibitor of aldose reductase an enzyme involved in the pathogenesis of complications of diabetes mellitus including diabetic neuropathy
CSN10270 Alrestatin 51411-04-2 Alrestatin is an inhibitor of aldose reductase an enzyme involved in the pathogenesis of complications of diabetes mellitus including diabetic neuropathy
CSN17745 Aldose Reductase-IN-1 1355612-71-3 Aldose reductase-IN-1 is an inhibitor of aldose reductase with IC50 of 289 pM
CSN23670 3-bromo-5-phenyl Salicylic Acid 4906-68-7 3-bromo-5-phenyl Salicylic Acid is a cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively).
CSN25361 2-Chloro-1-(4-fluorobenzyl)benzimidazole 84946-20-3
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