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Aldose Reductase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN36334 | Zopolrestat | 110703-94-1 | Zopolrestat is a aldose reductase inhibitor. |
| CSN12110 | Tolrestat | 82964-04-3 | Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 value of 35 nM. |
| CSN27705 | Ponalrestat | 72702-95-5 | Statil is a selective and noncompetitive aldose reductase 2 inhibitor with Ki value of 7.7nM. |
| CSN17888 | Ranirestat | 147254-64-6 | Ranirestat is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy |
| CSN16506 | Isoliquiritigenin | 961-29-5 | Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound. |
| CSN21685 | Imirestat | 89391-50-4 | Imirestat is an inhibitor of aldose reductase which is used for the treatment of diabetes. |
| CSN22130 | Fidarestat | 136087-85-9 | Fidarestat is an inhibitor of aldose reductase with IC50s of 26 nM 33 M and 18 M for aldose reductase AKR1B10 and V301L AKR1B10 respectively Fidarestat has the potential to treat diabetic disease |
| CSN12976 | Epalrestat | 82159-09-9 | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy. |
| CSN13622 | EBPC | 4450-98-0 | EBPC is a potent aldose reductase inhibitor which inhibits PGF2α production, enhances ERK activity and potentiates anticancer effects of cisplatin and doxorubicin. |
| CSN14844 | Dehydroglyasperin D | 517885-72-2 | Dehydroglyasperin D, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with anti-obesity, antioxidant, anti-aldose reductase, anticancer, anti-inflammator and strong ferric reducing activities, inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase, mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3, effectively scavenges DPPH, ABTS(+), and singlet oxygen radicals. |
| CSN15661 | Byakangelicin | 482-25-7 | Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. |
| CSN25218 | AT-007 | 2170729-29-8 | AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia. |
| CSN18314 | Alrestatin sodium | 51876-97-2 | Alrestatin sodium is an inhibitor of aldose reductase an enzyme involved in the pathogenesis of complications of diabetes mellitus including diabetic neuropathy |
| CSN10270 | Alrestatin | 51411-04-2 | Alrestatin is an inhibitor of aldose reductase an enzyme involved in the pathogenesis of complications of diabetes mellitus including diabetic neuropathy |
| CSN17745 | Caficrestat | 1355612-71-3 | Aldose reductase-IN-1 is an inhibitor of aldose reductase with IC50 of 289 pM |
| CSN23670 | AKR1C1-IN-1 | 4906-68-7 | 3-bromo-5-phenyl Salicylic Acid is a cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). |
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