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Akt

Akt

Cat. No. Product Name CAS No. Information
CSN21870 Triciribine Phosphate 61966-08-3 Triciribine Phosphate is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
CSN10320 Triciribine 35943-35-2 Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-12 with IC50 of 130 nM, and 0.02-0.46 M, respectively.
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 M
CSN18511 SC66   871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels
CSN11682 Perifosine   157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN19419 Oridonin   28957-04-2 Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens.
CSN13651 Nortrachelogenin 34444-37-6 Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure.
CSN16767 Miltefosine   58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN19405 Honokiol   35354-74-6 Honokiol inhibits Akt activation and enhances ERK1ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN25303 CCT128930 HCl 2453324-32-6 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN22684 API-1 36707-00-3 API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM respectively
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor which exerts efficacy in vitro and in vivo
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