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Akt

Akt

Cat. No. Product Name CAS No. Information
CSN10320 Triciribine 35943-35-2 Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-12 with IC50 of 130 nM, and 0.02-0.46 M, respectively.
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN15801 TIC10   1616632-77-9 TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor also inactivates ERK
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 M
CSN16878 SC79   305834-79-1 SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions
CSN18511 SC66   871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels
CSN16310 PHT-427 1191951-57-1 PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 27 M and 52 M respectively targeting PH domains of Akt and PDPK1
CSN11682 Perifosine     157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN16135 Nitidine Chloride 13063-04-2 Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway derived from genus Zanthoxylum
CSN15705 MK-2206 2HCl       1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
CSN16767 Miltefosine   58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN17777 LY3023414 1386874-06-1 LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms mTOR and DNA-PK with an IC50 of 649 nM 421 nM 106 nM 191 nM for Akt1 pT308 Akt1 pS473 P70S6 pT389 S6RP pS240242
CSN13165 GSK690693 937174-76-0 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
CSN13834 GSK2141795   1047634-65-0 GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,
CSN17426 GSK2141795 HCl 1047635-80-2 GSK2141795 hydrochloride is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1 328 nM for Akt2 and 38 nM for Akt3 respectively
CSN17425 GSK2110183 1047634-63-8 GSK2110183 is an orally bioavailable selective ATP-competitive and potent pan-Akt inhibitor with IC50s of 008226 nM for Akt1Akt2Akt3 respectively
CSN19148 GSK2110183 HCl 2070009-64-0 GSK2110183 hydrochloride is an orally bioavailable selective ATP-competitive and potent pan-Akt inhibitor with IC50s of 008226 nM for Akt1Akt2Akt3 respectively
CSN15783 GDC-0068     1001264-89-6 GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN17787 GDC-0068 2HCl 1396257-94-5 GDC-0068 dihydrochloride is a highly selective pan-Akt inhibitor targeting Akt123 with IC50 of 5 nM18 nM8 nM, 620-fold selectivity over PKA.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN15730 CCT128930 885499-61-6 CCT128930 is a potent ATP-competitive selective Akt2 inhibitor with an IC50 of 6 nM and 28-fold selectivity for Akt2 than the closely related PKA kinase
CSN18817 BAY1125976 1402608-02-9 BAY1125976 is a selective allosteric AKT12 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 52 nM and 18 nM at 10 M ATP respectively
CSN13769 AZD5363   1143532-39-1 AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
CSN16097 AT7867 857531-00-1 AT7867 is a potent ATP-competitive inhibitor of Akt123 and p70S6KPKA with IC50 of 32 nM17 nM47 nM and 85 nM20 nM respectively exhibiting little activity outside the AGC kinase family
CSN17845 AT7867 2HCl 1431697-86-7 AT7867 hydrochloride is a potent ATP-competitive inhibitor of Akt123 and p70S6KPKA with IC50 of 32 nM17 nM47 nM and 85 nM20 nM respectively and displaying little activity outside the AGC kinase family
CSN13758 AT13148 1056901-62-2 AT13148 is an oral ATP-competitive multi-AGC kinase inhibitor with IC50 of 38 nM402 nM50 nM 8 nM 3 nM and 6 nM4 nM for Akt123 p70S6K PKA and ROCKIII respectively
CSN17685 ARQ 092 Free Base 1313881-70-7 ARQ-092 is an orally bioavailable selective and potent allosteric Akt inhibitor with IC50 of 27 nM 14 nM and 81 nM for Akt1 Akt2 Akt3 respectively
CSN19250 ARQ 092 1313883-00-9 ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt2, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.
CSN18535 Akt1 and Akt2-IN-1 893422-47-4 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 IC50 35 nM and Akt2 IC50 42 nM with potent and balanced activity
CSN18455 AKT Kinase Inhibitor 842148-40-7 AKT kinase inhibitor is a compound with potent Akt inhibition activity
CSN17274 AKT Inhibitor 1004990-28-6 AKT inhibitor is a broadly selective potent ATP-competitive Akt inhibitor displays 900-fold greater selectivity for PKB IC50 05 nM than PKA IC50450 nM
CSN17427 Afuresertib     1047644-62-1 Afuresertib is a potent orally bioavailable Akt inhibitor with Ki of 008 nM 2 nM and 26 nM for Akt1 Akt2 and Akt3 respectively
CSN15693 Afuresertib HCl 1047645-82-8 Afuresertib HCl is a potent pan-Akt inhibitor with Ki values of 008 nM 2 nM and 26 nM for Akt1 Akt2 and Akt3 respectively
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM respectively
CSN19145 A-674563 HCl 2070009-66-2 A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM
CSN18330 A-443654 552325-16-3 A-443654 is a potent small-molecule inhibitor of all three Akt serinethreonine kinases induces Akt Ser-473 phosphorylation in all human cancer cell lines tested including PTEN- and TSC2-deficient lines
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor which exerts efficacy in vitro and in vivo
CSN14300 2'-Methoxykurarinone 270249-38-2
CSN14412 Hirsutenone 41137-87-5
CSN22684 API-1 36707-00-3
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