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Akt
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN21870 | Triciribine Phosphate | 61966-08-3 | Triciribine Phosphate is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively. |
| CSN10320 | Triciribine | 35943-35-2 | Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-12 with IC50 of 130 nM, and 0.02-0.46 M, respectively. |
| CSN16545 | TIC10 isomer | 41276-02-2 | TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| CSN15801 | TIC10 | 1616632-77-9 | TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor also inactivates ERK |
| CSN22511 | Solenopsin | 137038-57-4 | Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 M |
| CSN16878 | SC79 | 305834-79-1 | SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions |
| CSN18511 | SC66 | 871361-88-5 | SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels |
| CSN16251 | Psoralidin | 18642-23-4 | Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation. |
| CSN16310 | PHT-427 | 1191951-57-1 | PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 27 M and 52 M respectively targeting PH domains of Akt and PDPK1 |
| CSN11682 | Perifosine | 157716-52-4 | Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt. |
| CSN19419 | Oridonin | 28957-04-2 | Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. |
| CSN13651 | Nortrachelogenin | 34444-37-6 | Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure. |
| CSN21078 | M2698 | 1379545-95-5 | MSC2363318A, also known as M2698, is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. |
| CSN26580 | MK-2206 | 1032349-77-1 | MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC50s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. Anticancer activities[1][2]. |
| CSN15705 | MK-2206 dihydrochloride | 1032350-13-2 | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed. |
| CSN16767 | Miltefosine | 58066-85-6 | Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC. |
| CSN17777 | Samotolisib | 1386874-06-1 | LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms mTOR and DNA-PK with an IC50 of 649 nM 421 nM 106 nM 191 nM for Akt1 pT308 Akt1 pS473 P70S6 pT389 S6RP pS240242 |
| CSN19405 | Honokiol | 35354-74-6 | Honokiol inhibits Akt activation and enhances ERK1ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines. |
| CSN14412 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
| CSN13834 | Uprosertib | 1047634-65-0 | GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, |
| CSN17426 | Uprosertib hydrochloride | 1047635-80-2 | GSK2141795 HCl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively. |
| CSN19148 | GSK2110183 analog 1 hydrochloride | 2070009-64-0 | GSK2110183 HCl is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively. |
| CSN17425 | GSK2110183 analog 1 | 1047634-63-8 | GSK2110183 analog is an analog of GSK2110183. |
| CSN15783 | Ipatasertib | 1001264-89-6 | GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. |
| CSN17787 | Ipatasertib dihydrochloride | 1396257-94-5 | GDC-0068 2HCl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. |
| CSN24612 | FPA-124 | 902779-59-3 | FPA 124 is an inhibitor of Akt/PKB with IC50 of 100 nM that interacts with the PH and kinase domains. |
| CSN10218 | Ethyl gallate | 831-61-8 | Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9MMP-2, phosphorylation of Akt and protein expression of NF-B. |
| CSN13985 | Deguelin | 522-17-8 | Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect. |
| CSN25303 | CCT128930 hydrochloride | 2453324-32-6 | CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase. |
| CSN15730 | CCT128930 | 885499-61-6 | CCT128930 is a potent ATP-competitive selective Akt2 inhibitor with an IC50 of 6 nM and 28-fold selectivity for Akt2 than the closely related PKA kinase |
| CSN18817 | BAY1125976 | 1402608-02-9 | BAY1125976 is a selective allosteric AKT12 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 52 nM and 18 nM at 10 M ATP respectively |
| CSN16097 | AT7867 | 857531-00-1 | AT7867 is a potent ATP-competitive inhibitor of Akt123 and p70S6KPKA with IC50 of 32 nM17 nM47 nM and 85 nM20 nM respectively exhibiting little activity outside the AGC kinase family |
| CSN17845 | AT7867 dihydrochloride | 1431697-86-7 | AT7867 HCl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, and displaying little activity outside the AGC kinase family. |
| CSN17685 | Miransertib | 1313881-70-7 | ARQ-092 is an orally bioavailable selective and potent allosteric Akt inhibitor with IC50 of 27 nM 14 nM and 81 nM for Akt1 Akt2 Akt3 respectively |
| CSN19250 | Miransertib hydrochloride | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
| CSN22684 | API-1 | 36707-00-3 | API-1 is a selective Akt/PKB inhibitor and shows antitumor activity. |
| CSN18535 | Akt1 and Akt2-IN-1 | 893422-47-4 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 IC50 35 nM and Akt2 IC50 42 nM with potent and balanced activity |
| CSN18455 | AKT Kinase Inhibitor | 842148-40-7 | AKT kinase inhibitor is a compound with potent Akt inhibition activity |
| CSN17274 | PF-AKT400 | 1004990-28-6 | AKT inhibitor is a broadly selective potent ATP-competitive Akt inhibitor displays 900-fold greater selectivity for PKB IC50 05 nM than PKA IC50450 nM |
| CSN17427 | Afuresertib | 1047644-62-1 | Afuresertib is a potent orally bioavailable Akt inhibitor with Ki of 008 nM 2 nM and 26 nM for Akt1 Akt2 and Akt3 respectively |
| CSN16733 | A-674563 | 552325-73-2 | A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM respectively |
| CSN19145 | A-674563 hydrochloride | 2070009-66-2 | A-674563 HCl is a potent and selective Akt1 inhibitor with Ki of 11 nM. |
| CSN18330 | A-443654 | 552325-16-3 | A-443654 is a potent small-molecule inhibitor of all three Akt serinethreonine kinases induces Akt Ser-473 phosphorylation in all human cancer cell lines tested including PTEN- and TSC2-deficient lines |
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