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Akt

Akt

Cat. No. Product Name CAS No. Information
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN15801 TIC10   1616632-77-9 TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor also inactivates ERK
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 M
CSN16878 SC79   305834-79-1 SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions
CSN18511 SC66   871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels
CSN16310 PHT-427 1191951-57-1 PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 27 M and 52 M respectively targeting PH domains of Akt and PDPK1
CSN11682 Perifosine     157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN11644 Pachymic Acid 29070-92-6 Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties.
CSN19419 Oridonin   28957-04-2 Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens.
CSN16135 Nitidine Chloride 13063-04-2 Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway derived from genus Zanthoxylum
CSN15705 MK-2206 2HCl       1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
CSN16767 Miltefosine   58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN17777 LY3023414 1386874-06-1 LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms mTOR and DNA-PK with an IC50 of 649 nM 421 nM 106 nM 191 nM for Akt1 pT308 Akt1 pS473 P70S6 pT389 S6RP pS240242
CSN19405 Honokiol   35354-74-6 Honokiol inhibits Akt activation and enhances ERK1ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.
CSN13165 GSK690693 937174-76-0 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
CSN15783 GDC-0068     1001264-89-6 GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN17787 GDC-0068 2HCl 1396257-94-5 GDC-0068 2HCl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN15730 CCT128930 885499-61-6 CCT128930 is a potent ATP-competitive selective Akt2 inhibitor with an IC50 of 6 nM and 28-fold selectivity for Akt2 than the closely related PKA kinase
CSN18817 BAY1125976 1402608-02-9 BAY1125976 is a selective allosteric AKT12 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 52 nM and 18 nM at 10 M ATP respectively
CSN13769 AZD5363   1143532-39-1 AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
CSN16097 AT7867 857531-00-1 AT7867 is a potent ATP-competitive inhibitor of Akt123 and p70S6KPKA with IC50 of 32 nM17 nM47 nM and 85 nM20 nM respectively exhibiting little activity outside the AGC kinase family
CSN17845 AT7867 2HCl 1431697-86-7 AT7867 HCl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, and displaying little activity outside the AGC kinase family.
CSN13758 AT13148 1056901-62-2 AT13148 is an oral ATP-competitive multi-AGC kinase inhibitor with IC50 of 38 nM402 nM50 nM 8 nM 3 nM and 6 nM4 nM for Akt123 p70S6K PKA and ROCKIII respectively
CSN17685 ARQ 092 Free Base 1313881-70-7 ARQ-092 is an orally bioavailable selective and potent allosteric Akt inhibitor with IC50 of 27 nM 14 nM and 81 nM for Akt1 Akt2 Akt3 respectively
CSN19250 ARQ 092 1313883-00-9 ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt2, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.
CSN22684 API-1 36707-00-3 API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.
CSN18535 Akt1 and Akt2-IN-1 893422-47-4 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 IC50 35 nM and Akt2 IC50 42 nM with potent and balanced activity
CSN18455 AKT Kinase Inhibitor 842148-40-7 AKT kinase inhibitor is a compound with potent Akt inhibition activity
CSN17274 AKT Inhibitor 1004990-28-6 AKT inhibitor is a broadly selective potent ATP-competitive Akt inhibitor displays 900-fold greater selectivity for PKB IC50 05 nM than PKA IC50450 nM
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM respectively
CSN19145 A-674563 HCl 2070009-66-2 A-674563 HCl is a potent and selective Akt1 inhibitor with Ki of 11 nM.
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor which exerts efficacy in vitro and in vivo
CSN14300 2'-Methoxykurarinone 270249-38-2
CSN14412 Hirsutenone 41137-87-5
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