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ADC Toxin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN26799 | Py-MPB-amino-C3-PBD | 2412924-07-1 | Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. |
| CSN16844 | Methotrexate | 59-05-2 | Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. |
| CSN26800 | Maytansinoid DM4 | 799840-96-3 | Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2]. |
| CSN16581 | Camptothecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231. |
| CSN26801 | Aniline-MPB-amino-C3-PBD | 2412923-79-4 | |
| CSN42097 | Ansatrienin B | 82189-04-6 | |
| CSN50538 | AXC 715 | 313350-31-1 |
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