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AChR

AChR

Cat. No. Product Name CAS No. Information
CSN15876 VU 0357017 HCl   1135242-13-5 VU 0357017 HCl is a positive allosteric modulator of muscarinic M1 receptors with EC50 value of 198 nM
CSN12251 Varenicline Tartrate 375815-87-5 Varenicline tartrate is a nicotinic receptor partial agonist and it stimulates nicotine receptors more weakly than nicotine itself does
CSN12191 Varenicline 249296-44-4 Varenicline is a selective 42 nicotinic receptor partial agonist and it stimulates nicotine receptors more weakly than nicotine itself does
CSN13851 Umeclidinium Bromide   869113-09-7 Umeclidinium bromide is a long-acting mAchR antagonist with Ki values ranging in 0.05 to 0.16 nM for the cloned human M1-M5 mAChRs.
CSN12157 Trospium Chloride   10405-02-4 Trospium chloride is a competitive antagonist at muscarinic cholinergic receptors used to treat symptoms of an overactive bladder
CSN12517 Tolterodine Tartrate   124937-52-6 Tolterodine tartrate is a competitive mAchR antagonist possessing both antimuscarinic and antispasmodic properties.
CSN12516 Tolterodine 124937-51-5 Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
CSN12534 Tiotropium Bromide 136310-93-5 Tiotropium bromide is amAChR antagonist which acts through blocking the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
CSN21285 TD-4208 864750-70-9 TD-4208 is a long-actingmuscarinic cholinergic receptor (mAChR) antagonist and may be potentially useful for the treatment of respiratory disease.
CSN21941 Tacrine HCl H2O 206658-92-6 Tacirne is an active cholinesterase inhibitor that blocks the degradation of cholinergic nerves in the cerebral cortex and hippocampus to increase cholinergic transmission. Tacrine induces hepatic damages in vitro. It can also induce oxidative stress and mitochondrial dysfunction. Tacrine treatment in HepG2 cells markedly inhibits the phosphorylation of GSK3.
CSN16202 Solifenacin Succinate 242478-38-2 Solifenacin succinate is a muscarinic receptor antagonist Solifenacin succinate is a competitive and selective M3 receptor antagonist with elimination half-life of 45 to 68 hours
CSN18122 RJR-2403 Oxalate 220662-95-3 RJR-2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype (Ki26 nM), showing 1,000 fold selectivity than 7 receptors (Ki 36000 nM).
CSN17930 RJR-2403 15585-43-0 RJR-2403 is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype (Ki26 nM) showing 1,000 fold selectivity than 7 receptors (Ki 36000 nM).
CSN11852 Rivastigmine Tartrate   129101-54-8 Rivastigmine tartrate is an AchR inhibitor use for treatment of mild to moderate Alzheimers disease and Parkinsons disease with elimination half-life of 1.5 hours.
CSN12483 Pyrithioxin   1098-97-1 Pyrithioxin is a a nootropic.
CSN11810 Pyrithioxin 2HCl 10049-83-9 Pyrithioxin dihydrochloride is a neurodynamic compound combined with a short period of hyperventilation HV was applied in cerebral infarct patients with Hemiplegia
CSN11802 Pyrantel 15686-83-6 Pyrantel is a medication used to treat a number of parasitic worm infections
CSN11786 Propantheline Bromide 50-34-0 Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.
CSN11734 Pirenzepine 2HCl   29868-97-1 Pirenzepine diHCl is a is an anticholinergic agent and induces the dimerization of muscarinic M1 receptors, used to treat myopia, gastric and duodenal ulcers.
CSN11635 Oxybutynin   5633-20-5 Oxybutynin a synthetic anticholinergic agent used for treatment of urinary incontinence and overactive bladder syndrome with elimination half-life of 124132 hours
CSN16263 Otilonium Bromide   26095-59-0 Otilonium bromide is an mAchR antagonist used world-wide for the treatment of irritable bowel syndrome.
CSN11539 Neostigmine Bromide   114-80-7 Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine bromide is a reversible AchR inhibitor but can not cross the blood-brain barrier.
CSN21136 Methylbenactyzium Bromide   3166-62-9 Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.
CSN17103 Acetyl-β-methylcholine chloride   62-51-1 Methacholine chloride is a quaternary ammonium parasympathomimetic agent targeting on mAchR.
CSN16311 mAChR-IN-1 119391-56-9 mAChR-IN-1 is a potent muscarinic cholinergic receptor mAChR antagonist with IC50 of 17 nM
CSN19428 Lobeline HCl   134-63-4 Lobeline HCl is a mixed agonistantagonist of nAchR agonist and has multiple function such as VMAT2 ligand, inhibiting the reuptake of dopamine and serotonin, antagonist at -opioid receptors and P-glycoprotein inhibitor.
CSN11289 Levamisole HCl   16595-80-5 Levamisole HCl is a nAChR agonist used as an anthelmintic to treat worm infestations.
CSN11213 Ipratropium Bromide' 22254-24-6 Ipratropium bromide is a synthetic derivative of the alkaloid atropine anticholinergic properties with anticholinergic properties
CSN18004 Imidafenacin 170105-16-5 Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and less potent for M2 receptors (IC504.13 nM).
CSN11146 Hexamethonium Bromide   55-97-0 Hexamethonium bromide is a nicotinic cholinergic antagonist as the prototypical ganglionic blocker
CSN13182 GTS-21 2HCl 156223-05-1 GTS-21 dihydrochloride is a selective 7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
CSN11109 Glycopyrrolate 596-51-0 Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic.
CSN11077 Gallamine Triethiodide   65-29-2 Gallamine triethiodide is a competitive cholinergic receptor blocker with an IC50 of 680 84 M used as a non-depolarising muscle relaxant
CSN11016 Flavoxate HCl   3717-88-2 Flavoxate HCl is a competitive AChR antagonist with IC50 of 12.2 M, used as a muscle relaxant.
CSN16494 EVP-6124 HCl 550999-74-1 EVP-6124 hydrochloride is a partial agonist of 7 neuronal nicotinic acetylcholine receptors nAChRs
CSN12506 Donepezil HCl   120011-70-3 Donepezil HCl is a selective and reversible AchE inhibitor highly selective for the central nervous system and used in the management of mild to moderate Alzheimers disease and dementia
CSN16149 Darifenacin Hydrobromide   133099-07-7 Darifenacin hydrobromide is a M3-selective antagonist with pKi of 89 an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome
CSN11123 Cytisine   485-35-8 Cytisine is a naturally occuring alkaloid nAchR agonist with a short half-life of 4.8 hours.
CSN10604 Cevimeline 107233-08-9 Cevimeline is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors and used in the treatment of dry mouth associated with sjogrens syndrome.
CSN17915 Cevimeline Hydrochloride Hemihydrate 153504-70-2 Cevimeline hydrochloride, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogrens syndrome.
CSN17444 Cevimeline HCl 107220-28-0 Cevimeline hydrochloride is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors and used in the treatment of dry mouth associated with sjogrens syndrome.
CSN16245 Catharanthine 2468-21-5 Catharanthine showed muscarinic antagonism at 10 M and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 596 M As a precursor of the anti-tumor drugs vinblastine and vincristine it also works as an inhibitor of tubulin self-assembly into microtubules
CSN24270 Bisindolylmaleimide xHCl 145317-11-9 Bisindolylmaleimide is a potent PKC inhibitor and also a potent nAChR antagonist.
CSN10454 Biperiden HCl 1235-82-1 Biperiden hydrochloride is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
CSN22357 Beperidium Iodide 86434-57-3 Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
CSN10072 Benzethonium Chloride   121-54-0 Benzethonium chloride can inhibit nAChRs with IC50 values of 49 nM and 122 nM for 42 nAChRs and 7 nAChRs, respectively. It is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
CSN16775 Atracurium Besylate 64228-81-5 Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action.
CSN10215 Aclidinium Bromide 320345-99-1 Aclidinium bromide is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD).
CSN12416 (R)-Fesoterodine Fumarate 286930-03-8 (R)-Fesoterodine fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
CSN12360 (R)-5-Hydroxymethyl Tolterodine 207679-81-0 (R)-5-Hydroxymethyl tolterodine is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively.
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