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ACC

ACC

Cat. No. Product Name CAS No. Information
CSN20332 Olumacostat Glasaretil 1261491-89-7 Olumacostat glasaretil is an acetyl-CoA carboxylase inhibitor, and inhibits acetyl-coenzyme A carboxylase, which is responsible for the first, rate-limiting step in de novo fatty acid synthesis. Olumacostat glasaretil has been used in the treatment of acne vulgaris.
CSN21233 ND-646 1434639-57-2 ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth
CSN21232 ND-630 1434635-54-7 ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase ACC dimerization that inhibits ACC1 and ACC2 activity IC50s 21 and 61 nM respectively for the human enzymes
CSN21110 MK-4074 1039758-22-9 MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM
CSN18348 CP-640186 HCl 591778-70-0 CP-640186 HCl is a metabolic stability improved ACC inhibitor with IC50 values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2respectively
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