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ACC
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN22083 | TOFA | 54857-86-2 | TOFA is a cell-permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC). |
| CSN24313 | PF-05175157 | 1301214-47-0 | PF-05175157 is a potent and selective ACC inhibitor with IC50 values of 27nM and 33nM for ACC1 and ACC2, respectively. |
| CSN20332 | Olumacostat glasaretil | 1261491-89-7 | Olumacostat glasaretil is an acetyl-CoA carboxylase inhibitor, and inhibits acetyl-coenzyme A carboxylase, which is responsible for the first, rate-limiting step in de novo fatty acid synthesis. Olumacostat glasaretil has been used in the treatment of acne vulgaris. |
| CSN21233 | ND-646 | 1434639-57-2 | ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth |
| CSN21232 | Firsocostat | 1434635-54-7 | ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase ACC dimerization that inhibits ACC1 and ACC2 activity IC50s 21 and 61 nM respectively for the human enzymes |
| CSN21110 | MK-4074 | 1039758-22-9 | MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM |
| CSN18348 | CP-640186 hydrochloride | 591778-70-0 | CP-640186 HCl is a metabolic stability improved ACC inhibitor with IC50 values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2respectively |
| CSN43859 | CMS-121 | 1353224-53-9 | |
| CSN68607 | CP-610431 | 591778-83-5 | |
| CSN74833 | A-908292 | 903886-95-3 | |
| CSN76107 | SABA1 | 690681-65-3 | |
| CSN75676 | S-2E | 155730-92-0 |
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