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ACC

ACC

Cat. No. Product Name CAS No. Information
CSN22083 TOFA 54857-86-2 TOFA is a cell-permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC).
CSN24313 PF-05175157   1301214-47-0 PF-05175157 is a potent and selective ACC inhibitor with IC50 values of 27nM and 33nM for ACC1 and ACC2, respectively.
CSN20332 Olumacostat glasaretil 1261491-89-7 Olumacostat glasaretil is an acetyl-CoA carboxylase inhibitor, and inhibits acetyl-coenzyme A carboxylase, which is responsible for the first, rate-limiting step in de novo fatty acid synthesis. Olumacostat glasaretil has been used in the treatment of acne vulgaris.
CSN21233 ND-646 1434639-57-2 ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth
CSN21232 Firsocostat 1434635-54-7 ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase ACC dimerization that inhibits ACC1 and ACC2 activity IC50s 21 and 61 nM respectively for the human enzymes
CSN21110 MK-4074 1039758-22-9 MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM
CSN18348 CP-640186 hydrochloride 591778-70-0 CP-640186 HCl is a metabolic stability improved ACC inhibitor with IC50 values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2respectively
CSN33172 PF-05221304 1370448-25-1 Clesacostat is a potent and selective ACC inhibitor.
CSN43859 CMS-121 1353224-53-9
CSN68607 CP-610431 591778-83-5
CSN74833 A-908292 903886-95-3
CSN76107 SABA1 690681-65-3
CSN75676 S-2E 155730-92-0
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