||Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.
||V-9302 HCl is a competitive and selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter
||Defensamide is an activator of SPHK1, and significantly stimulates CAMP mRNA and protein production in KC.
||is phenolic antioxidant with anti-inflammatory and antiplatelet effects and is potentially useful for the treatment of atherosclerosis and type 2 diab
||E260 is an inhibitor of the Fer/FerT kinase with Kd of 0.85 μM, selectively evokes metabolic stress and necrotic death in cancer cells.
||IKE is a potent, metabolically stable inhibitor of system Xc- and inducer of ferroptosis potentially suitable for in vivo applic
||Baloxavir marboxil is an inhibitor of cap-dependent endonuclease of influenza A and B viruses.
||BAY-218 is an AHR antagonist.
||D3-βArr is a positive allosteric TSH Receptor modulator.
||ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.
||GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
||NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which specific and reversible inhibits the interaction of N-Acetyl-UBE2M and
||1A-116 is a specific Rac1 inhibitor.
||Calcein is a compound used for fluorometric determination of calcium and EDTA titration.
||ML-18 is a nonpeptide BRS-3 antagonist with IC50 value of 4.8μM.
||Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis.
||Anle138b is an oligomeric aggregation inhibitor which can block the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein
||BMS-986195 is a potent, covalent, irreversible BTK inhibitor with IC50 value of 0.1nM.
||SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist.
||LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
||Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor.
||BQR695 is a PI4K specific inhibitor with IC50 value of 80nM.
||MK-7246 is a potent and selective CRTH2 antagonist with Ki value of 2.5nM.
||GI 530159 is a selective and mechano-sensitive K2P channel opener, exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium c
||FDI-6 is an inhibitor of FOXM1 that block DNA binding. It act by specifically downregulating FOXM1-activated genes.
||GSK3179106 is a potent, selective and gut-restricted RET kinase inhibitor with IC50 value of 0.4nM.
||Gardiquimod trifluoroacetate is a specific TLR7 agonist.
||SAR-20347 is a TYK2 and JAK inhibitor with IC50 values of 0.6, 23, 26 and 41nM for TYK2, JAK1, JAK2 and JAK3, respectively.
||JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.
||EN6 covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). It is a small-molecule in vivo activato
||Acid Red 52
||Sulforhodamine B is a dye used for cell density determination, based on the measurement of cellular protein content.
||WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) with IC50 of 0.3 μM.
||Losartan carboxylic acid
||EXP 3174 is a selective and noncompetitive antagonist of AT1 receptor with IC50 of 37 nM.
||KKL-35, a potent member of the oxadiazole family, against the human pathogen Legionella pneumophila and other related species that can also cause Legi
||2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
||Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
||TP353 is a CDK7 inhibitor.
||MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer.
||Emodepside is an antiparasitic that is effective against a number of gastrointestinal nematodes, used in cat.
||Spermidine, a precursor of spermine, is a polyamine derived from putrescine and could help stabilize some membranes and nucleic acid structures.
||RG-13022 significantly inhibited EGF-stimulated autophosphorylation of its receptor in two breast cancer cell lines that have abundant, although not a
||RG3039 is an orally bioavailable and brain-penetrant DcpS inhibitor with IC50 of 0.069 nM.
||EIDD-2801 is an orally bioavailable prodrug of EIDD-1931, which has a broad-spectrum antiviral activity against 39 multiple coronaviruses, including S
||Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It
||CADD522 is a small molecule that inhibits the DNA binding of RUNX2. It negatively regulated transcription of RUNX2 target genes such as matrix metallo
||OGG1 Inhibitor O8
||O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG
||Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, oral
||MAC-545496 is a nanomolar inhibitor of GraR. It reverses β-lactam resistance in the community-acquired MRSA USA300 strain.
||VLX600 is preferentially active against quiescent cells in colon cancer 3-D microtissues. VLX600 shows enhanced cytotoxic activity under conditions of
||JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent a