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Cat. No. Product Name CAS No. Information
CSN11594 Obatoclax  803712-79-0 Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 MolL), including Mcl-1 (IC50, 2.9 Mo
CSN11862 Roscovitine  186692-46-6 Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6
CSN11980 Staurosporine  62996-74-1 Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine pr
CSN12171 U0126 Ethanol  1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 70/60nM.
CSN12378 SNS-032  345627-80-7 SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
CSN12386 Selumetinib  606143-52-6 Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to
CSN12394 Ruxolitinib  941678-49-5 Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3
CSN12423 Danusertib  827318-97-8 Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13 79 and 61 nM for Aurora A B and C respectively
CSN12932 ABT-263  923564-51-6 ABT-263 is a potent inhibitor of Bcl-xL Bcl-2 and Bcl-w with Ki ≤ 0.5nM, ≤1 nM and ≤1 nM in cell-free assays.
CSN12964 Cabazitaxel  183133-96-2 Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts it
CSN13146 MK-4827  1038915-60-4 MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 38 and 21 nM respectively
CSN13457 Alisertib  1028486-01-2 Alisertib is a selective Aurora inhibitor with IC50 of 12 nM with 200-fold higher selectivity for Aurora A than Aurora B
CSN13470 CHIR-99021  252917-06-9 CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, exhibiting > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, a
CSN13496 Romidepsin  128517-07-7 Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
CSN13643 SCH772984  942183-80-4 SCH772984 is a specific inhibitor of ERK12 with IC50 of 4 nM and 1 nM respectively
CSN13709 Alpelisib  1217486-61-7 Alpelisib is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kβ/γ/δ.
CSN13769 AZD5363  1143532-39-1 AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
CSN15705 MK-2206 2HCl  1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 oth
CSN15784 Ulixertinib  869886-67-9 Ulixertinib is a potent and reversible ERK1ERK2 inhibitor with IC50 of 0.3 nM for ERK2.
CSN15844 KU-60019  925701-46-8 KU-60019 is an improved analogue of KU-55933 with IC50 of 63 nM for ATM
CSN15885 BMN-673  1207456-01-6 BMN-673 is a PARP12 inhibitor with IC50 of 0.57 nM for PARP1.
CSN15902 GSK2606414  1337531-36-8 GSK2606414 is an orally available potent and selective PERK inhibitor with an IC50 of 04 nM
CSN15907 GSK343  1346704-33-3 GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM showing 60 fold selectivity against EZH1 and 1000 fold selectivity against other hi
CSN15936 Z-VAD(OMe)-FMK  187389-52-2 Z-VADOMe-FMK is a cell-permeable irreversible broad-spectrum caspase inhibitor blocks all features of apoptosis
CSN16001 ARRY-162  606143-89-9 ARRY-162 is a potent inhibitor of MEK12 with IC50 of 12 nM in a cell-free assay.
CSN16144 BGJ398  872511-34-7 BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective
CSN16419 CP-673451  343787-29-1 CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors
CSN16593 PND-1186  1061353-68-1 PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
CSN16885 A-1210477  1668553-26-1 A-1210477 is a potent and selective inhibitor of MCL-1 and weakly binds to BCL-2 and BCL-XL with Ki of 045 nM 132 nM and 660 nM respectively
CSN17114 KU-55933  587871-26-9 KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 22 nM respectively and highly selective for ATM as compared to DNA-PK PI3KPI4K ATR an
CSN17224 CH5183284  1265229-25-1 CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respec
CSN17445 Defactinib  1073154-85-4 Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1mediated paclitaxel resistance by an AKT-dependent pathway.
CSN17559 DMH-1  1206711-16-1 DMH-1 is a potent and selective BMP inhibitor with IC50s of 27107.9 5 nM for ALK123 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2.
CSN18355 LY2090314  603288-22-8 LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
CSN19165 SIS3  521984-48-5 SIS3 is an inhibitor of Smad3 and can inhibit TGF-β and activin signaling without affecting other pathways.
CSN12426 ABT-737  852808-04-9 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL Bcl-2 and Bcl-w with EC50 of 787 nM 303 nM and 1978 nM respectively showing no inhibition observed agains
CSN16483 PF-573228  869288-64-2 PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK p
CSN16219 CPI-203  1446144-04-2 CPI 203 is a potent selective and cell permeable inhibitor of the bromodomain and extra terminal BET family protein BRD4 with an IC50 of 37 nM BRD4 -s
CSN19269 Bafetinib  859212-16-1 Bafetinib is a potent and selective dual Bcr-AblLyn inhibitor with IC50 of 5.8 nM19 nM in cell-free assays, does not inhibit the phosphorylation of th
CSN13061 I-BET-762  1260907-17-2 I-BET 762 is an inhibitor for BET proteins with IC50 of 35 nM.
CSN13737 PF-562271 Besylate  939791-38-5 PF-562271 besylate is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 15 nM 10-fold less potent for Pyk2 than FAK and 100-fold sele
CSN13471 BMS-777607  1025720-94-8 BMS-777607 is a Met-related inhibitor for c-Met Axl Ron and Tyro3 with IC50 of 39 nM 11 nM 18 nM and 43 nM being 40-fold selective for Met-related tar
CSN13841 Z-IETD-FMK  210344-98-2 Z-IETD-FMK is a specific Caspase-8 inhibitor
CSN16124 Ki20227  623142-96-1 Ki-20227 is a highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50 value of 2 nM, displaying 6 fold and 100 fold selectivity over VEGFR
CSN12687 Ponatinib  943319-70-8 Ponatinib is a potent multi-target inhibitor of Abl PDGFR VEGFR2 FGFR1 and Src with IC50 of 037 nM 11 nM 15 nM 22 nM and 54 nM respectively
CSN13834 GSK2141795  1047634-65-0 GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,
CSN15884 PKC412  120685-11-2 PKC412 is a broad spectrum protein kinase inhibitor and inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, P
CSN16208 AT7519  844442-38-2 AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB
CSN16271 GDC-0994  1453848-26-4 GDC-0994 is a selective inhibitor of ERK1/2 with IC50 value of 6.1 nM and 3.1 nM.
CSN19253 2-Methoxyestradiol  362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC
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